Gene info: ID 5888

Gene: RAD51

GENE ID: 5888

Description: RAD51 recombinase

Gene type: protein-coding

Location: 15q15.1

dbXrefs: Ensembl:ENSG00000285396 MIM:179617 Vega:OTTHUMG00000130067 UniprotKB:Q06609

RefSeq: NG_012120.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.651e-2 (AD) 2.574e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2412546	chr15:40714325 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NMT2	0.54
CCDC149	0.524
TBC1D22A	0.508
APAF1	0.508
MMS19	0.508
GGA3	0.505
MSL3	0.504
CUL7	0.503
METTL15	0.502
LRMP	0.501

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RSPO1	-0.275
KCNK5	-0.268
S100A14	-0.246
HIST1H4D	-0.239
OR4F5	-0.239
DIO2	-0.237
SLC25A48	-0.236
CPSF4L	-0.231
QRFP	-0.226
COPZ2	-0.223

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule		Experimental	Target
DB12742	Amuvatinib	Small Molecule	850879-09-3	Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of RAD51 mRNA"	26377693
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of RAD51 mRNA"	23958786
C582286	1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	RAD51 mutant form results in increased susceptibility to 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	26208482
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of RAD51 mRNA"	23626729
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RAD51 mRNA"	22698814\|2362672
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RAD51 mRNA"	20566336
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of RAD51]	24525463
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAD51 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of RAD51 mRNA"	20713471
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of RAD51 mRNA	25088246
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA"	23681119
C479235	2-(morpholin-4-yl)benzo(h)chromen-4-one	[irinotecan co-treated with 2-(morpholin-4-yl)benzo(h)chromen-4-one] results in increased expression of RAD51 protein	21221710
C471109	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	"4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased expression of RAD51 mRNA"	19934314
C006757	4-biphenylamine	4-biphenylamine results in decreased expression of RAD51 mRNA	24857880
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of RAD51 mRNA	19191707
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of RAD51 mRNA	19191707
D000082	Acetaminophen	Acetaminophen results in increased expression of RAD51 mRNA	22230336
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D020106	Acrylamide	Acrylamide results in increased expression of RAD51 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RAD51 mRNA	23630614
D000393	Air Pollutants	Air Pollutants results in increased expression of RAD51 protein	28389379
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of RAD51 mRNA"	22863853
D000677	Amsacrine	RAD51 protein affects the susceptibility to Amsacrine	16600179
D001151	Arsenic	Arsenic affects the methylation of RAD51 gene	25304211
C015001	arsenite	arsenite results in decreased expression of RAD51 mRNA	18929588
C547126	AZM551248	AZM551248 results in increased expression of RAD51 mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RAD51 mRNA	27858113
D001554	Benzene	Benzene results in decreased expression of RAD51 mRNA	18724895
D001554	Benzene	Benzene results in increased expression of RAD51 mRNA	15342939
D001554	Benzene	TRP53 protein affects the reaction [Benzene results in decreased expression of RAD51 mRNA]	12928149
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RAD51 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of RAD51 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RAD51 mRNA	20064835
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RAD51 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RAD51 mRNA	20713471
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAD51 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D004958	Estradiol	Estradiol results in increased expression of RAD51 mRNA	16474171\|1831028
C006780	bisphenol A	bisphenol A affects the expression of RAD51 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of RAD51 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of RAD51 mRNA	16474171\|2257669
C006780	bisphenol A	bisphenol A results in decreased expression of RAD51 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in decreased expression of RAD51 mRNA	21917757
C016274	bromoacetate	bromoacetate results in increased expression of RAD51 mRNA	19753638
D002066	Busulfan	Busulfan results in decreased expression of RAD51 mRNA	15388331
C584509	C646 compound	C646 compound results in decreased expression of RAD51 mRNA	23698071
D002104	Cadmium	Cadmium results in decreased expression of RAD51 mRNA	18522720
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RAD51 mRNA	25456234
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RAD51 mRNA	16799861
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RAD51 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RAD51 mRNA	25993096
D002166	Camptothecin	Camptothecin results in decreased expression of RAD51 mRNA	10344722\|2479264
D002166	Camptothecin	Camptothecin results in decreased expression of RAD51 protein	10344722
D002220	Carbamazepine	Carbamazepine affects the expression of RAD51 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of RAD51 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RAD51 mRNA	27339419
D002330	Carmustine	Carmustine results in decreased expression of RAD51 mRNA	15980968
D002699	Chlorambucil	Chlorambucil results in increased expression of RAD51 protein	10473103
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD51	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD51 gene	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAD51 mRNA	20938992
D002857	Chromium	Chromium results in increased expression of RAD51 mRNA	18084045
C074702	chromium hexavalent ion	chromium hexavalent ion affects the phosphorylation of and affects the expression of RAD51 protein	25173789
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of and results in decreased localization of RAD51 protein	27449664
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RAD51 mRNA	27858113
D003033	Coal Tar	Coal Tar results in decreased expression of RAD51 mRNA	27858113
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of RAD51 mRNA	20971185
D003300	Copper	Copper results in increased expression of RAD51 mRNA	17205981
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RAD51 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAD51 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of RAD51 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of RAD51 mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of RAD51 protein	21878529
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of RAD51 mRNA	21878529
D003474	Curcumin	acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D003474	Curcumin	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D003474	Curcumin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D003474	Curcumin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D003474	Curcumin	Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]	21810436
D003474	Curcumin	MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D003474	Curcumin	MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D003474	Curcumin	[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA	21810436
D003474	Curcumin	RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]	21810436
D003474	Curcumin	U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D003474	Curcumin	U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of RAD51 mRNA	21041162
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of RAD51 mRNA	11599041
D016572	Cyclosporine	Cyclosporine results in decreased expression of RAD51 mRNA	25562108
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of RAD51 mRNA	23726867
C017160	cypermethrin	cypermethrin results in increased expression of RAD51 mRNA	21142847
D003561	Cytarabine	Cytarabine results in increased expression of RAD51 mRNA	19194470
D003609	Dactinomycin	Dactinomycin results in decreased expression of RAD51 mRNA	27989139
D003609	Dactinomycin	tetrachlorobenzoquinone promotes the reaction [Dactinomycin results in decreased expression of RAD51 mRNA]	27989139
D000069439	Dasatinib	Dasatinib results in decreased expression of RAD51 mRNA	20579391
C014347	decitabine	decitabine affects the localization of RAD51 protein modified form	17991895
D003703	Demecolcine	Demecolcine affects the localization of RAD51 protein	9885240
D015255	Idarubicin	[Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA	28973540
D003907	Dexamethasone	Dexamethasone results in decreased expression of RAD51 mRNA	21041162
D064730	Dexrazoxane	[Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA	28973540
C023614	dibenzofuran	dibenzofuran analog results in decreased expression of RAD51 mRNA	20566336
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of RAD51 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of RAD51 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of RAD51 protein	26723870
D002945	Cisplatin	Cisplatin results in increased expression of RAD51 protein	26723870
D002945	Cisplatin	NQO1 protein affects the reaction [Cisplatin results in increased expression of RAD51 protein]	26723870
D002945	Cisplatin	Cisplatin results in decreased expression of RAD51 mRNA	22023808
D004008	Diclofenac	Diclofenac affects the expression of RAD51 mRNA	24752500
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of RAD51 mRNA	26924002
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RAD51 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RAD51 mRNA	17854601
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RAD51 protein	18506893
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAD51 mRNA]	17854601
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of RAD51 mRNA	21041162
D002117	Calcitriol	Calcitriol results in decreased expression of RAD51 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of RAD51 mRNA	21592394
D017878	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of RAD51 protein"	23589568
D017878	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	"[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of RAD51 protein] which results in increased activity of AICDA protein"	23589568
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAD51 mRNA"	25448685
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAD51 protein"	25448685
D015127	9,10-Dimethyl-1,2-benzanthracene	"A gene mutant form affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAD51 protein]"	25448685
D015127	9,10-Dimethyl-1,2-benzanthracene	"A gene mutant form inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAD51 mRNA]"	25448685
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAD51 mRNA"	23969067
D004126	Dimethylformamide	Dimethylformamide results in increased expression of RAD51 mRNA	26387567
D004126	Dimethylformamide	Dimethylformamide results in increased expression of RAD51 protein	26387567
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of RAD51 mRNA	26924002
D004317	Doxorubicin	Doxorubicin affects the expression of RAD51 protein	17351394
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD51 mRNA	10344722
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD51 protein	10344722
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD51 mRNA	27181935
D004317	Doxorubicin	Doxorubicin results in decreased expression of RAD51 protein	24902966
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD51 mRNA]	27181935
D004317	Doxorubicin	Quercetin inhibits the reaction [Doxorubicin results in decreased expression of RAD51 protein]	24902966
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of RAD51 mRNA	26159488
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAD51 mRNA	22079256
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein	23548265
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of RAD51 mRNA	24412560
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of RAD51 mRNA	24412560
C007633	estragole	estragole results in increased expression of RAD51 protein	29054680
D005047	Etoposide	Etoposide affects the localization of RAD51 protein	9885240
D015025	Zearalenone	Zearalenone results in decreased expression of RAD51 mRNA	27862621
D015025	Zearalenone	Zearalenone results in increased expression of RAD51 mRNA	28552778
D015025	Zearalenone	Zearalenone results in increased expression of RAD51 protein	28552778
C024352	fludarabine	[LAQ824 co-treated with fludarabine] results in decreased expression of RAD51 mRNA	18852132
C012976	flumequine	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA"	23681119
D005485	Flutamide	Flutamide results in decreased expression of RAD51 mRNA	21126777
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD51	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD51 gene	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAD51 mRNA	20938992
C070081	fulvestrant	[fulvestrant co-treated with Sirolimus] results in decreased expression of RAD51 mRNA	19016759
C070081	fulvestrant	fulvestrant results in decreased expression of RAD51 mRNA	19016759
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of RAD51 mRNA]	27181935
C039281	furan	furan results in decreased expression of RAD51 mRNA	22507866
C039281	furan	furan results in increased expression of RAD51 mRNA	25539665
D019833	Genistein	Genistein results in increased expression of RAD51 mRNA	16474171
D017313	Fenretinide	Fenretinide results in increased expression of RAD51 mRNA	28973697
C575866	IC486241	[irinotecan co-treated with IC486241] results in increased expression of RAD51 protein	21221710
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD51 mRNA	25613284
C051890	irinotecan	[irinotecan co-treated with 2-(morpholin-4-yl)benzo(h)chromen-4-one] results in increased expression of RAD51 protein	21221710
C051890	irinotecan	[irinotecan co-treated with IC486241] results in increased expression of RAD51 protein	21221710
C051890	irinotecan	irinotecan results in increased expression of RAD51 protein	21221710
C544151	jinfukang	jinfukang results in increased expression of RAD51 mRNA	27392435
C561695	(+)-JQ1 compound	[BCL2L1 protein co-treated with RAD51 protein] inhibits the reaction [GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound]	26397223
C561695	(+)-JQ1 compound	[BCL2L1 protein co-treated with RAD51 protein] inhibits the reaction [[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased cleavage of PARP1 protein]	26397223
C561695	(+)-JQ1 compound	[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of RAD51 mRNA	26397223
C561695	(+)-JQ1 compound	[GNAQ gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in decreased expression of RAD51 protein	26397223
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [GNAQ gene mutant form promotes the reaction [BRD4 protein binds to RAD51 promoter]]	26397223
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RAD51 mRNA	24796395
C410337	K 7174	K 7174 results in decreased expression of RAD51 mRNA	24086573
C477361	LAQ824	[LAQ824 co-treated with fludarabine] results in decreased expression of RAD51 mRNA	18852132
D007840	Latex	Latex analog results in increased expression of RAD51 mRNA	24768652
C045463	leflunomide	leflunomide results in decreased expression of RAD51 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of RAD51 mRNA	12057914
D008154	Lucanthone	Lucanthone results in decreased expression of RAD51 mRNA	21148553
D008466	Mechlorethamine	Mechlorethamine results in increased expression of RAD51 protein	25891025
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of RAD51	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RAD51 gene	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RAD51 mRNA	20938992
D008731	Methoxychlor	Methoxychlor results in decreased expression of RAD51 mRNA	21276474
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of RAD51 mRNA	20713471
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of RAD51 mRNA	15984772
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of RAD51 mRNA	15984772
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RAD51 protein	24743697
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RAD51 mRNA	23649840
D016685	Mitomycin	acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D016685	Mitomycin	acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D016685	Mitomycin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D016685	Mitomycin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D016685	Mitomycin	Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]	21810436
D016685	Mitomycin	MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D016685	Mitomycin	MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D016685	Mitomycin	[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA	21810436
D016685	Mitomycin	Mitomycin results in increased expression of RAD51 protein	21810436
D016685	Mitomycin	RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]	21810436
D016685	Mitomycin	U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
D016685	Mitomycin	U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of RAD51 protein	24625837
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of RAD51 mRNA	26924002
D009151	Mustard Gas	BRCA2 protein inhibits the reaction [Mustard Gas affects the localization of RAD51 protein]	20435105
D009151	Mustard Gas	Mustard Gas affects the localization of RAD51 protein	20435105
D009151	Mustard Gas	BRCA2 protein inhibits the reaction [Mustard Gas affects the localization of RAD51 protein]	20435105
D009151	Mustard Gas	Mustard Gas affects the localization of RAD51 protein	20435105
D009151	Mustard Gas	RAD51 protein results in decreased susceptibility to Mustard Gas	20435105
C005246	myristicin	myristicin results in decreased expression of RAD51 mRNA	24792648
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of RAD51 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of RAD51 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of RAD51 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of RAD51 mRNA	25583101
C022838	nickel chloride	nickel chloride results in decreased expression of RAD51 mRNA	28472268
C022838	nickel chloride	nickel chloride results in decreased expression of RAD51 protein	28472268
C022838	nickel chloride	nickel chloride affects the expression of RAD51 mRNA	22110744
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RAD51 mRNA"	12888634
C010615	Nonidet P-40	Nonidet P-40 results in decreased expression of RAD51 mRNA	26552463
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of RAD51 mRNA	20971185
C025589	ochratoxin A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of RAD51]	24525463
C025589	ochratoxin A	ochratoxin A results in decreased expression of RAD51	24525463
C025589	ochratoxin A	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of RAD51]	24525463
C025589	ochratoxin A	TP53 mutant form inhibits the reaction [ochratoxin A results in decreased expression of RAD51]	24525463
C025589	ochratoxin A	ochratoxin A results in increased expression of RAD51 mRNA	24243707
C025589	ochratoxin A	ochratoxin A results in increased expression of RAD51 protein	24243707
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD51 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of RAD51 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of RAD51 mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in decreased expression of RAD51 protein	25030372\|2847226
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RAD51 mRNA	25658374
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of RAD51 mRNA]	19555225
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RAD51 mRNA"	25510870
C011272	perfosfamide	perfosfamide results in decreased expression of RAD51 mRNA	11754170
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of RAD51 mRNA	26678675
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RAD51 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RAD51 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of RAD51 mRNA	19482888\|2309116
C030090	phosphoramide mustard	phosphoramide mustard affects the expression of RAD51 mRNA	25497287
C030090	phosphoramide mustard	phosphoramide mustard affects the expression of RAD51 protein	25497287
C030090	phosphoramide mustard	phosphoramide mustard results in decreased expression of RAD51 protein	26708502
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of RAD51 mRNA	26708502
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of RAD51 mRNA	21061450
D048789	Phytoestrogens	Phytoestrogens results in increased expression of RAD51 mRNA	18310284
C121565	pifithrin	pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein]	27989139
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of RAD51 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of RAD51 mRNA	17950772\|2081375
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of RAD51 mRNA]	17950772
D010936	Plant Extracts	Plant Extracts results in decreased expression of RAD51 mRNA	23557933
D010936	Plant Extracts	Plant Extracts results in increased expression of RAD51 mRNA	23557933
D028321	Plant Preparations	Plant Preparations affects the expression of RAD51 mRNA	16046712
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of RAD51 mRNA	16474171
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RAD51 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of RAD51 mRNA	22079256\|2271453
D011285	Pregnenolone Carbonitrile	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of RAD51 mRNA"	23626729
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of RAD51 mRNA	22698814
D011353	Prodigiosin	Prodigiosin results in decreased expression of RAD51 mRNA	22579953
D011353	Prodigiosin	Prodigiosin results in decreased expression of RAD51 protein	22579953
D011353	Prodigiosin	pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]	22579953
D011353	Prodigiosin	RAD51 protein results in decreased susceptibility to Prodigiosin	22579953
D011353	Prodigiosin	SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]	22579953
D011374	Progesterone	Progesterone affects the expression of RAD51 mRNA	17251523
C045950	propiconazole	propiconazole results in increased expression of RAD51 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil affects the expression of RAD51 mRNA	24780913
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]	22579953
D011794	Quercetin	Quercetin inhibits the reaction [Doxorubicin results in decreased expression of RAD51 protein]	24902966
D011794	Quercetin	Quercetin results in increased expression of RAD51 protein	24902966
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of RAD51 mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of RAD51 mRNA	15149879
C547185	riccardin D	riccardin D results in decreased expression of RAD51 mRNA	24069304
D012402	Rotenone	Rotenone results in increased expression of RAD51 mRNA	18191903
C093642	SB 203580	SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of RAD51]	24525463
C093642	SB 203580	SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]	22579953
D020123	Sirolimus	[fulvestrant co-treated with Sirolimus] results in decreased expression of RAD51 mRNA	19016759
C017947	sodium arsenite	sodium arsenite results in decreased expression of RAD51 mRNA	16014739\|2578715
C016104	sodium bichromate	sodium bichromate results in increased expression of RAD51 mRNA	22155349
C016104	sodium bichromate	sodium bichromate affects the expression of RAD51 mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in increased expression of RAD51 mRNA	25993096
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of RAD51 mRNA	10344722\|1817575
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of RAD51 protein	10344722
D053260	Soot	Soot results in increased expression of RAD51 mRNA	22461453\|2655175
D013629	Tamoxifen	Tamoxifen results in decreased expression of RAD51 protein	17219426
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of RAD51 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of RAD51 mRNA	21592394
C000591600	tetrachlorobenzoquinone	pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein]	27989139
C000591600	tetrachlorobenzoquinone	RAD51 protein inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CASP3 protein modified form]	27989139
C000591600	tetrachlorobenzoquinone	RAD51 protein inhibits the reaction [tetrachlorobenzoquinone results in increased expression of H2AFX protein modified form]	27989139
C000591600	tetrachlorobenzoquinone	RAD51 protein results in decreased susceptibility to tetrachlorobenzoquinone	27989139
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone affects the expression of RAD51 mRNA	27989139
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone affects the expression of RAD51 protein	27989139
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone affects the reaction [TP53 protein binds to RAD51 protein]	27989139
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone promotes the reaction [Dactinomycin results in decreased expression of RAD51 mRNA]	27989139
C000591600	tetrachlorobenzoquinone	TP53 protein promotes the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein]	27989139
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone affects the expression of RAD51 protein	27989139
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RAD51 mRNA	16714409
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of RAD51 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RAD51 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RAD51 mRNA	15667827
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RAD51 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of RAD51 mRNA	22659510
C009495	titanium dioxide	titanium dioxide results in increased expression of RAD51 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of RAD51 mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of RAD51 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD51 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of RAD51 mRNA	18230668
D014241	Trichloroethylene	Trichloroethylene results in increased expression of RAD51 mRNA	25549359
C012589	trichostatin A	trichostatin A results in decreased expression of RAD51 mRNA	23770000
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of RAD51 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RAD51 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of RAD51 mRNA	19140230
C113580	U 0126	U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]	21810436
C113580	U 0126	U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]	21810436
D014520	Urethane	Urethane results in decreased expression of RAD51 mRNA	28818685
D014527	Uric Acid	NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]	23619996
D014527	Uric Acid	Uric Acid results in decreased expression of RAD51 mRNA	23619996
D014635	Valproic Acid	Valproic Acid results in decreased expression of RAD51 mRNA	20585447
D014635	Valproic Acid	Valproic Acid results in decreased expression of RAD51 mRNA	24913804
D014635	Valproic Acid	Valproic Acid results in increased expression of RAD51 mRNA	24913804
C029297	vinylidene chloride	vinylidene chloride results in increased expression of RAD51 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of RAD51 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of RAD51 protein	20646843
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of RAD51 mRNA"	21315451
C023616	zinc chromate	zinc chromate affects the phosphorylation of and affects the expression of RAD51 protein	25173789
C023616	zinc chromate	zinc chromate results in decreased expression of and results in decreased localization of RAD51 protein	27449664

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000150	recombinase activity	-	IBA	21873635
GO:0000400	four-way junction DNA binding	-	IBA	21873635
GO:0003690	double-stranded DNA binding	-	IBA	21873635
GO:0003690	double-stranded DNA binding	-	IDA	7988572
GO:0003690	double-stranded DNA binding	-	IMP	26681308
GO:0003697	single-stranded DNA binding	-	IBA	21873635
GO:0003697	single-stranded DNA binding	-	IDA	7988572
GO:0003697	single-stranded DNA binding	-	IMP	26681308
GO:0004520	endodeoxyribonuclease activity	CONTRIBUTES_TO	IBA	21873635
GO:0005515	protein binding	-	IPI	8675009 9380510 9396801 9461559 9560268 9660962 10551859 11309417 11842113 12242698 12442171 12750383 15665856 15800615 16186822 16395335 16756962 16990250 17541404 18264088 19303847 19338310 19628690 20154705 20729832 20729859 20871616 21252223 21307306 21399666 21601571 21903585 21965664 22116401 22153967 22193777 22293751 22641345 23393192 23509288 23754376 24108124 24141787 25282148 25585578 25640309 25642963 26323318 28575657
GO:0005524	ATP binding	-	IDA	16428451
GO:0008022	protein C-terminus binding	-	IPI	17515903
GO:0008094	DNA-dependent ATPase activity	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	9396801 9469824 9660962 12442171 19622740 19628690 25282148
GO:0043142	single-stranded DNA-dependent ATPase activity	-	IDA	7988572 8929543
GO:0043142	single-stranded DNA-dependent ATPase activity	-	IMP	26681308
GO:0070182	DNA polymerase binding	-	IPI	19995904

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000707	meiotic DNA recombinase assembly	-	IBA	21873635
GO:0000722	telomere maintenance via recombination	-	ISS	21076401
GO:0000724	double-strand break repair via homologous recombination	-	IDA	16428451
GO:0000724	double-strand break repair via homologous recombination	-	IMP	22778135 23509288 26681308
GO:0000724	double-strand break repair via homologous recombination	-	TAS	12427746
GO:0000730	DNA recombinase assembly	-	IBA	21873635
GO:0000730	DNA recombinase assembly	-	IMP	26681308
GO:0006268	DNA unwinding involved in DNA replication	-	IDA	7988572
GO:0006281	DNA repair	-	TAS	8358431
GO:0006310	DNA recombination	-	TAS	7988572
GO:0006312	mitotic recombination	-	IBA	21873635
GO:0006312	mitotic recombination	-	TAS	8358431
GO:0006974	cellular response to DNA damage stimulus	-	IDA	23509288 25585578
GO:0006974	cellular response to DNA damage stimulus	-	IMP	26681308
GO:0007131	reciprocal meiotic recombination	-	IBA	21873635
GO:0007131	reciprocal meiotic recombination	-	TAS	8358431
GO:0010212	response to ionizing radiation	-	IBA	21873635
GO:0010569	regulation of double-strand break repair via homologous recombination	-	IDA	23754376
GO:0010833	telomere maintenance via telomere lengthening	-	ISS	21076401
GO:0031297	replication fork processing	-	IDA	25585578
GO:0031297	replication fork processing	-	IMP	22778135
GO:0036297	interstrand cross-link repair	-	IMP	26253028
GO:0042148	strand invasion	-	IBA	21873635
GO:0051106	positive regulation of DNA ligation	-	IDA	8929543
GO:0051260	protein homooligomerization	-	IPI	12442171
GO:0051321	meiotic cell cycle	-	ISS	-
GO:0070192	chromosome organization involved in meiotic cell cycle	-	IBA	21873635
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	-
GO:0071479	cellular response to ionizing radiation	-	IDA	23509288 23754376
GO:0072757	cellular response to camptothecin	-	IDA	23509288
GO:1990426	mitotic recombination-dependent replication fork processing	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000228	nuclear chromosome	-	IDA	23754376
GO:0000784	nuclear chromosome, telomeric region	-	IDA	21076401
GO:0000785	chromatin	-	IDA	25585578
GO:0000790	nuclear chromatin	-	IDA	26323318
GO:0000793	condensed chromosome	-	ISS	-
GO:0000794	condensed nuclear chromosome	-	IBA	21873635
GO:0000794	condensed nuclear chromosome	-	ISS	-
GO:0000800	lateral element	-	IDA	9774970
GO:0005634	nucleus	-	IDA	12442171 16215984 18417535 25585578 26323318 26681308
GO:0005634	nucleus	-	ISS	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005657	replication fork	-	IBA	21873635
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	16215984 25585578 26681308
GO:0005739	mitochondrion	-	IDA	20413593
GO:0005759	mitochondrial matrix	-	IEA	-
GO:0005815	microtubule organizing center	-	IEA	-
GO:0005829	cytosol	-	IDA	-
GO:0016605	PML body	-	IDA	11309417
GO:0032991	protein-containing complex	-	IDA	16990250
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	-	IBA	21873635
GO:0035861	site of double-strand break	-	IDA	24550317
GO:0048471	perinuclear region of cytoplasm	-	IDA	16215984

KEGG ID	KEGG Term
hsa03440	Homologous recombination
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1474165	Reproduction	IEA
R-HSA-1500620	Meiosis	IEA
R-HSA-1640170	Cell Cycle	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693537	Resolution of D-Loop Structures	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	TAS
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	TAS
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953750	Transcriptional Regulation by E2F6	TAS
R-HSA-912446	Meiotic recombination	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26131267	Association between RAD51 polymorphisms and susceptibility of head and neck cancer: a meta-analysis. (2015)	Kong F	Int J Clin Exp Med
23319983	Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population. (2012 Dec 20)	Romanowicz-Makowska H	Arch Med Sci
26507587	Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate. (2016 Feb)	Machado RA	Am J Med Genet A
20804747	Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population. (2010 Dec)	Sliwinski T	Exp Mol Pathol
29459183	Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. (2018 Apr)	Nikodemova M	Environ Int
22740911	Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study. (2012 Feb)	Zhang L	Oncol Lett
19960343	Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy. (2010 Aug)	Nogueira A	Cancer Chemother Pharmacol
28078281	The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer. (2016)	Martinez-Useros J	Biomed Res Int
18768166	Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption. (2008 Oct 30)	Werbrouck J	Mutat Res
28191342	Dose-Response Curves of the FDXR and RAD51 Genes with 6 and 18 MV Beam Energies in Human Peripheral Blood Lymphocytes. (2016 Nov)	Saberi A	Iran Red Crescent Med J