Gene: RASGRF2

5924
GRF2|RAS-GRF2
Ras protein specific guanine nucleotide releasing factor 2
protein-coding
5q14.1
Ensembl:ENSG00000113319 MIM:606614 Vega:OTTHUMG00000119015 UniprotKB:O14827
NG_030334.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.213e-1 (AD)  5.223e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7733625chr5:81086987 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs506598chr5:81019851 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRTM40.929
NLK0.925
GRIA40.923
BTBD30.919
LNX10.915
C11orf870.915
KCTD160.915
MAGI10.911
EPHA40.91
IGSF30.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.521
MYL3-0.512
RNF135-0.504
HEBP2-0.502
RAB13-0.495
CSAG1-0.495
ACAP1-0.489
ROM1-0.487
CHST14-0.484
TGIF1-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RASGRF2 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RASGRF2 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RASGRF2 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 mRNA"12606953
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of RASGRF2 protein"12606953
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RASGRF2 mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RASGRF2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RASGRF2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RASGRF2 gene27153756
D000447AldehydesAldehydes results in increased expression of RASGRF2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RASGRF2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RASGRF2 mRNA24449571
C015001arsenitearsenite results in increased methylation of RASGRF2 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of RASGRF2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RASGRF2 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of RASGRF2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of RASGRF2 mRNA26079696
D000001CalcimycinCalcimycin affects the localization of RASGRF2 protein16000378
D000001CalcimycinCalcimycin promotes the reaction [RASGRF2 protein binds to HRAS protein]16000378
D000001CalcimycinCRYAB protein inhibits the reaction [Calcimycin affects the localization of RASGRF2 protein]16000378
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RASGRF2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RASGRF2 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of RASGRF2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RASGRF2 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of RASGRF2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of RASGRF2 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of RASGRF2 mRNA]27392435
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
D017313FenretinideFenretinide results in decreased expression of RASGRF2 mRNA28973697
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of RASGRF2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of RASGRF2 mRNA]27392435
C045463leflunomideleflunomide results in increased expression of RASGRF2 mRNA28988120
C018091maduramicinmaduramicin results in increased expression of RASGRF2 mRNA29128925
C042720mercuric bromidemercuric bromide results in increased expression of RASGRF2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RASGRF2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of RASGRF2 mRNA22401849
C046012pentanalpentanal results in increased expression of RASGRF2 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RASGRF2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RASGRF2 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of RASGRF2 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RASGRF2 mRNA23806026|2589566
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RASGRF2 mRNA18087596
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RASGRF2 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RASGRF2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of RASGRF2 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RASGRF2 gene25560391
C025643vinclozolinvinclozolin affects the expression of RASGRF2 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of RASGRF2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-IMP27856453  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005516calmodulin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0034976response to endoplasmic reticulum stress-IMP27856453  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27992614A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. (2016)Novo-Veleiro IPLoS One
24737505Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain. (2014 Oct)Easton ACPsychopharmacology (Berl)
25454123Rasgrf2 controls dopaminergic adaptations to alcohol in mice. (2014 Oct)Easton ACBrain Res Bull