Gene: RGS12

6002
-
regulator of G protein signaling 12
protein-coding
4p16.3
Ensembl:ENSG00000159788 MIM:602512 Vega:OTTHUMG00000090277 UniprotKB:O14924
NG_029903.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.813e-1 (AD)  1.792e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16844280chr4:3407297 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11732375chr4:3395236 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24453153chr4:3416849RGS12Gene body5.423e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAK60.869
RPS6KA40.86
FMNL10.852
AMPD20.846
PLCH20.843
DMWD0.843
KIFC20.843
REXO10.842
DGKZ0.841
RAB11FIP30.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.566
OR4F29-0.51
FCGR3B-0.414
DTHD1-0.379
CXCR2-0.376
CLEC2B-0.372
VNN2-0.371
S100A12-0.368
KCNJ15-0.365
CNTF-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RGS12 mRNA"26377693
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of RGS12 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RGS12 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of RGS12 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RGS12 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of RGS12 mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RGS12 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS12 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RGS12 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of RGS12 mRNA"25351596
D001280AtrazineAtrazine results in decreased expression of RGS12 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of RGS12 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RGS12 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RGS12 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of RGS12 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RGS12 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS12 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RGS12 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RGS12 mRNA21569818|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RGS12 mRNA22610609|2373587
C044887beta-methylcholinebeta-methylcholine affects the expression of RGS12 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of RGS12 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RGS12 gene28505145
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RGS12 mRNA27858113
D002994ClofibrateClofibrate results in decreased expression of RGS12 mRNA23811191
D003033Coal TarCoal Tar results in increased expression of RGS12 mRNA27858113
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RGS12 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RGS12 mRNA19549813
C014347decitabinedecitabine results in increased expression of RGS12 mRNA19194470
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RGS12 mRNA17361019|2126653
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RGS12 mRNA18164116
C024629dimethyl phthalatedimethyl phthalate affects the expression of RGS12 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RGS12 mRNA17108234
C069837fullerene C60fullerene C60 results in increased expression of RGS12 mRNA19167457
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of RGS12 mRNA22634610
D017313FenretinideFenretinide results in increased expression of RGS12 mRNA28973697
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of RGS12 mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of RGS12 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of RGS12 mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of RGS12 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RGS12 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RGS12 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RGS12 mRNA25729387
D010795Phthalic AcidsPhthalic Acids results in increased expression of RGS12 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of RGS12 mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of RGS12 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of RGS12 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of RGS12 protein17337753
D012822Silicon DioxideSilicon Dioxide results in increased expression of RGS12 mRNA25351596
D013605T-2 ToxinT-2 Toxin results in decreased expression of RGS12 mRNA26141394
D013629TamoxifenTamoxifen results in increased expression of RGS12 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS12 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RGS12 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS12 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RGS12 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RGS12 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of RGS12 mRNA23527032|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RGS12 gene25487561
D015032ZincZinc deficiency results in increased expression of RGS12 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030695GTPase regulator activity-IDA9651375  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007165signal transduction-IEA-  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS9651375  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-TAS10869340  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-ISS-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0016363nuclear matrix-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-ISS-  
GO:0045202synapsecolocalizes_withISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-372790Signaling by GPCRIEA
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal