Gene: ELOVL5

60481
HELO1|SCA38|dJ483K16.1
ELOVL fatty acid elongase 5
protein-coding
6p12.1
Ensembl:ENSG00000012660 MIM:611805 Vega:OTTHUMG00000016249 UniprotKB:Q9NYP7
NG_034263.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.318e-1 (AD)  6.524e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2281274chr6:53278756 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFE2L20.889
CNN30.868
PLOD20.86
FERMT20.856
MAGT10.856
SLC39A10.856
SH3GLB10.855
GNA130.843
CPNE30.843
ITGAV0.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.475
OR4F29-0.447
SLC7A4-0.378
ABCC12-0.374
MYOZ3-0.371
HTR6-0.368
CALHM1-0.365
CACNA1F-0.355
KNCN-0.352
RTP1-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ELOVL5 mRNA"28903501
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ELOVL5 mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ELOVL5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ELOVL5 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of ELOVL5 mRNA"20702594
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ELOVL5 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL5 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ELOVL5 mRNA"19561079
C0293704-toluidine4-toluidine results in decreased expression of ELOVL5 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ELOVL5 mRNA21420995
C016601afimoxifeneafimoxifene results in decreased expression of ELOVL5 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ELOVL5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ELOVL5 mRNA19770486
C430898AGN 194204AGN 194204 results in increased expression of ELOVL5 mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ELOVL5 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of ELOVL5 mRNA19128835
D001241AspirinAspirin results in decreased expression of ELOVL5 mRNA11906190
D001241AspirinAspirin results in increased expression of ELOVL5 mRNA15928584
D001280AtrazineAtrazine results in decreased expression of ELOVL5 mRNA25929836
D001554BenzeneBenzene results in increased expression of ELOVL5 mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of ELOVL5 promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ELOVL5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ELOVL5 mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ELOVL5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ELOVL5 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of ELOVL5 mRNA16514628
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ELOVL5 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ELOVL5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ELOVL5 mRNA21932408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ELOVL5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ELOVL5 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of ELOVL5 mRNA24136188
D002104CadmiumCadmium results in decreased expression of ELOVL5 mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ELOVL5 mRNA25993096
C018021cobaltous chloridecobaltous chloride results in decreased expression of ELOVL5 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of ELOVL5 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL5 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of ELOVL5 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of ELOVL5 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ELOVL5 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ELOVL5 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ELOVL5 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ELOVL5 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ELOVL5 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of ELOVL5 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of ELOVL5 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ELOVL5 mRNA19245819|1985064
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ELOVL5 mRNA]19850644
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ELOVL5 mRNA25380136
D004147DioxinsDioxins affects the expression of ELOVL5 mRNA20463971
D000431EthanolEthanol results in decreased expression of ELOVL5 mRNA19167417
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELOVL5 mRNA17942748
D005227Fatty AcidsELOVL5 protein results in increased metabolism of Fatty Acids16790840
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of ELOVL5 mRNA"23333450
D005229Fatty Acids, Monounsaturated"ELOVL5 protein results in increased metabolism of Fatty Acids, Monounsaturated"16790840
D005231Fatty Acids, Unsaturated"ELOVL5 protein results in increased metabolism of Fatty Acids, Unsaturated"16790840
C082360fipronilfipronil results in decreased expression of ELOVL5 mRNA23962444
D005395Fish OilsFish Oils results in decreased activity of ELOVL5 protein15654130
D005395Fish OilsFish Oils results in decreased expression of ELOVL5 mRNA15654130
D005472FluorouracilELOVL5 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of ELOVL5 mRNA21126777
D005485FlutamideFlutamide results in increased expression of ELOVL5 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of ELOVL5 mRNA19167457
C070081fulvestrantfulvestrant results in decreased expression of ELOVL5 mRNA16514628
D019833GenisteinGenistein results in decreased expression of ELOVL5 mRNA15378649
C492448ICG 001ICG 001 results in decreased expression of ELOVL5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ELOVL5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ELOVL5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ELOVL5 mRNA28628672
C410337K 7174K 7174 results in increased expression of ELOVL5 mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of ELOVL5 mRNA16807920
D064704LevofloxacinLevofloxacin results in decreased expression of ELOVL5 mRNA24136188
D008627Mercuric ChlorideMercuric Chloride affects the expression of ELOVL5 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ELOVL5 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of ELOVL5 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ELOVL5 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ELOVL5 protein26558463
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of ELOVL5 mRNA24128854
D008942MitoxantroneELOVL5 mRNA affects the susceptibility to Mitoxantrone16044152
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ELOVL5 mRNA20024957
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ELOVL5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ELOVL5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ELOVL5 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ELOVL5 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of ELOVL5 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of ELOVL5 mRNA24136188
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ELOVL5 mRNA19074003
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of ELOVL5 mRNA"23333450
D015525Fatty Acids, Omega-3"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of ELOVL5 mRNA]"23333450
D015525Fatty Acids, Omega-3"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Omega-3 results in decreased expression of ELOVL5 mRNA]"23333450
D000073878Palm OilPalm Oil results in decreased expression of ELOVL5 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of ELOVL5 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ELOVL5 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ELOVL5 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ELOVL5 mRNA23427857
D010656PhenylephrinePhenylephrine results in increased expression of ELOVL5 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ELOVL5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ELOVL5 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ELOVL5 mRNA15728792
C014153pirimiphos methylpirimiphos methyl results in decreased expression of ELOVL5 mRNA27845199
C006253pirinixic acidpirinixic acid results in increased expression of ELOVL5 mRNA16790840|1830175
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of ELOVL5 mRNA]16790840
C006253pirinixic acidpirinixic acid results in increased activity of ELOVL5 protein15654130
C006253pirinixic acidpirinixic acid results in increased expression of ELOVL5 mRNA15654130
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ELOVL5 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of ELOVL5 mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ELOVL5 mRNA16514628
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of ELOVL5 mRNA19167446
C059514resveratrolresveratrol results in increased expression of ELOVL5 protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of ELOVL5 mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ELOVL5 mRNA21427059
C016104sodium bichromatesodium bichromate results in decreased expression of ELOVL5 mRNA25993096
C013698tallowtallow affects the expression of ELOVL5 mRNA19680557
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ELOVL5 mRNA]21079772
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ELOVL5 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELOVL5 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELOVL5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ELOVL5 mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELOVL5 mRNA16611356|1696003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELOVL5 mRNA16960034|1846511
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ELOVL5 mRNA28973375
D013752TetracyclineTetracycline results in increased expression of ELOVL5 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ELOVL5 mRNA25613284
D013893ThiramThiram results in decreased expression of ELOVL5 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ELOVL5 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased expression of ELOVL5 mRNA25549359
C406224valdecoxibvaldecoxib results in decreased expression of ELOVL5 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ELOVL5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ELOVL5 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ELOVL5 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ELOVL5 mRNA21126777
D015034Zinc OxideZinc Oxide affects the expression of ELOVL5 mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20937905  
GO:0009922fatty acid elongase activity-EXP10970790  12371743  14636670  
GO:0009922fatty acid elongase activity-IBA21873635  
GO:0009922fatty acid elongase activity-IDA20427700  
GO:01023363-oxo-arachidoyl-CoA synthase activity-IEA-  
GO:01023373-oxo-cerotoyl-CoA synthase activity-IEA-  
GO:01023383-oxo-lignoceronyl-CoA synthase activity-IEA-  
GO:0102756very-long-chain 3-ketoacyl-CoA synthase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-IEA-  
GO:0019367fatty acid elongation, saturated fatty acid-IBA21873635  
GO:0030148sphingolipid biosynthetic process-IBA21873635  
GO:0034625fatty acid elongation, monounsaturated fatty acid-IBA21873635  
GO:0034625fatty acid elongation, monounsaturated fatty acid-IDA20427700  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IBA21873635  
GO:0034626fatty acid elongation, polyunsaturated fatty acid-IDA20427700  20937905  
GO:0035338long-chain fatty-acyl-CoA biosynthetic process-TAS-  
GO:0036109alpha-linolenic acid metabolic process-TAS-  
GO:0042761very long-chain fatty acid biosynthetic process-IBA21873635  
GO:0042761very long-chain fatty acid biosynthetic process-IDA20427700  20937905  
GO:0043651linoleic acid metabolic process-TAS-  
GO:0045723positive regulation of fatty acid biosynthetic process-IMP23749231  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA20937905  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IDA25065913  
GO:0097447dendritic tree-IDA25065913  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2046104alpha-linolenic (omega3) and linoleic (omega6) acid metabolismTAS
R-HSA-2046105Linoleic acid (LA) metabolismTAS
R-HSA-2046106alpha-linolenic acid (ALA) metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal