Gene: NAA35

60560
EGAP|MAK10|MAK10P|bA379P1.1
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
protein-coding
9q21.33
Ensembl:ENSG00000135040 Vega:OTTHUMG00000020131 UniprotKB:Q5VZE5
NC_000009.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.215e-1 (AD)  5.066e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9410906chr9:86015871 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs511395chr9:85947477 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USO10.911
USP9X0.907
NUP1530.907
HECTD10.906
CCDC470.905
SEL1L0.905
CBLL10.903
CAPRIN10.902
UBE3A0.902
NEMF0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.551
OR4F29-0.532
NKX6-1-0.279
CSAG1-0.278
MTRNR2L6-0.267
MTRNR2L10-0.26
PTGDR2-0.258
APOA1-0.257
HMX1-0.255
KLRB1-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NAA35 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NAA35 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NAA35 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of NAA35 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NAA35 mRNA16483693
D001151ArsenicArsenic affects the methylation of NAA35 gene25304211
C006780bisphenol Abisphenol A results in increased expression of NAA35 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NAA35 mRNA26472689
D016572CyclosporineCyclosporine results in increased expression of NAA35 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NAA35 mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAA35 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAA35 mRNA17942748
D018120FinasterideFinasteride results in increased expression of NAA35 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NAA35 mRNA21126777
D005485FlutamideFlutamide results in increased expression of NAA35 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of NAA35 mRNA19167457
D005897GlafenineGlafenine results in decreased expression of NAA35 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NAA35 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NAA35 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NAA35 mRNA23649840
D010100OxygenOxygen deficiency results in increased expression of NAA35 mRNA24205000
C016030pantogabpantogab results in decreased expression of NAA35 mRNA17379144
C006253pirinixic acidpirinixic acid results in decreased expression of NAA35 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of NAA35 mRNA18301758|2381119
D013467SulindacSulindac results in decreased expression of NAA35 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAA35 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAA35 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAA35 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NAA35 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of NAA35 mRNA28973697
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NAA35 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004596peptide alpha-N-acetyltransferase activity-IBA21873635  
GO:0005515protein binding-IPI19398576  
GO ID GO Term Qualifier Evidence PubMed
GO:0006474N-terminal protein amino acid acetylation-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP19398576  
GO:0048659smooth muscle cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19398576  
GO:0005737cytoplasm-ISS-  
GO:0005844polysomecolocalizes_withIDA19398576  
GO:0031417NatC complex-IBA21873635  
GO:0031417NatC complex-IDA19398576  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingIEA
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkIEA
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal