Gene: CELF6

60677
BRUNOL6
CUGBP Elav-like family member 6
protein-coding
15q23
Ensembl:ENSG00000140488 MIM:612681 Vega:OTTHUMG00000186423 UniprotKB:Q96J87
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.102e-1 (AD)  9.055e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2959930chr15:72306273 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1300.919
ARHGEF90.918
DNAJC50.914
MTA30.914
MPP20.913
MADD0.912
NUDCD30.911
MORN40.911
ATCAY0.911
TOMM40L0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.554
OR4F29-0.496
KCNJ15-0.467
CST7-0.458
IL18RAP-0.457
CLEC2B-0.455
TFPI2-0.455
RAI14-0.448
CSAG1-0.447
MTRNR2L6-0.441

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CELF6 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CELF6 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of CELF6 mRNA19774075
C006780bisphenol Abisphenol A affects the expression of CELF6 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CELF6 mRNA26472689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELF6 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of CELF6 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CELF6 mRNA20106945
D003976DiazinonDiazinon results in increased methylation of CELF6 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CELF6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CELF6 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of CELF6 mRNA25016146
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CELF6 mRNA"23811387
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELF6 gene20938992
C082359imidaclopridimidacloprid results in increased expression of CELF6 mRNA27782041
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CELF6 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of CELF6 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELF6 gene20938992
D009285NaphthoquinonesNaphthoquinones results in increased expression of CELF6 mRNA23811387
D009532NickelNickel results in decreased expression of CELF6 mRNA24768652|2558310
D009538NicotineNicotine results in increased expression of CELF6 mRNA27782041
D011441PropylthiouracilPropylthiouracil results in increased expression of CELF6 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in increased expression of CELF6 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CELF6 mRNA24680724
D014635Valproic AcidValproic Acid affects the expression of CELF6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CELF6 mRNA23527032
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CELF6 gene25560391
C111237vorinostatvorinostat results in decreased expression of CELF6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-NAS14761971  
GO:0003729mRNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IDA14761971  
GO:0006376mRNA splice site selection-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-NAS14761971  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-NAS14761971  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal