Gene: EEFSEC

60678
EFSEC|SELB
eukaryotic elongation factor, selenocysteine-tRNA specific
protein-coding
3q21.3
Ensembl:ENSG00000132394 MIM:607695 Vega:OTTHUMG00000159659 UniprotKB:P57772
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
9.547e-1 (AD)  9.206e-1 (ND)   (Frontal_Cortex)
9.759e-1 (AD)  6.908e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2999090chr3:128212497 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOM10.905
GPS10.896
CCAR20.894
VPS180.893
ARMC60.892
MCRS10.89
VPS110.889
GSS0.889
COPG10.887
AP1M10.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.657
OR4F29-0.603
MTRNR2L6-0.345
MTRNR2L9-0.345
RAI14-0.308
MTRNR2L10-0.306
C9orf153-0.3
PPBP-0.298
CXCL3-0.285
CLEC2B-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of EEFSEC mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EEFSEC protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EEFSEC gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EEFSEC mRNA19770486
D001151ArsenicArsenic affects the methylation of EEFSEC gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EEFSEC mRNA20106945|2163298
C018475butyraldehydebutyraldehyde results in decreased expression of EEFSEC mRNA26079696
D002945CisplatinCisplatin results in decreased expression of EEFSEC mRNA19561079
D018120FinasterideFinasteride results in increased expression of EEFSEC mRNA24136188
D005485FlutamideFlutamide results in decreased expression of EEFSEC mRNA24793618
D005485FlutamideFlutamide results in increased expression of EEFSEC mRNA24136188
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of EEFSEC mRNA19376150
D007213IndomethacinIndomethacin results in increased expression of EEFSEC mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EEFSEC mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of EEFSEC mRNA19136613
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EEFSEC mRNA26011545
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EEFSEC mRNA21570461
D014520UrethaneUrethane results in decreased expression of EEFSEC mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EEFSEC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of EEFSEC gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EEFSEC mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of EEFSEC mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EEFSEC gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IEA-  
GO:0003746translation elongation factor activity-IBA21873635  
GO:0003746translation elongation factor activity-IEA-  
GO:0003924GTPase activity-IEA-  
GO:0005525GTP binding-IEA-  
GO:0035368selenocysteine insertion sequence binding-IEA-  
GO:0043021ribonucleoprotein complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001514selenocysteine incorporation-IBA21873635  
GO:0001514selenocysteine incorporation-IEA-  
GO:0006414translational elongation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:1990904ribonucleoprotein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal