Gene: ZFAND3

60685
TEX27
zinc finger AN1-type containing 3
protein-coding
6p21.2
Ensembl:ENSG00000156639 MIM:607455 Vega:OTTHUMG00000014629 UniprotKB:Q9H8U3
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.590e-1 (AD)  3.621e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6901928chr6:37969526 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01284595chr6:38079362ZFAND3Gene body4.519e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMBIM60.907
CD810.89
ALDH20.89
CYB5R30.889
FYN0.883
HNRNPUL10.879
CLU0.879
HADHA0.874
GUCD10.873
WBP1L0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.767
OR4F29-0.75
TYRP1-0.23
ZNF860-0.208
CNGB3-0.2
ADTRP-0.199
NRG1-0.195
CSN1S1-0.194
QRFPR-0.191
TRABD2A-0.185

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ZFAND3 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of ZFAND3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ZFAND3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZFAND3 gene27153756
D000393Air PollutantsAir Pollutants results in decreased expression of ZFAND3 mRNA25056781
D001151ArsenicArsenic affects the methylation of ZFAND3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZFAND3 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZFAND3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZFAND3 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of ZFAND3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ZFAND3 promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of ZFAND3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of ZFAND3 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ZFAND3 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZFAND3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZFAND3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZFAND3 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZFAND3 mRNA27392435
D004317DoxorubicinDoxorubicin results in increased oxidation of ZFAND3 protein28818578
D000431EthanolEthanol affects the expression of ZFAND3 mRNA26730594
D005839GentamicinsGentamicins results in decreased expression of ZFAND3 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of ZFAND3 mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZFAND3 protein18951874
C492448ICG 001ICG 001 results in increased expression of ZFAND3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZFAND3 mRNA27392435
C410337K 7174K 7174 results in increased expression of ZFAND3 mRNA24086573
D007854LeadLead affects the splicing of ZFAND3 mRNA28903495
C045463leflunomideleflunomide results in increased expression of ZFAND3 mRNA28988120
C045463leflunomideleflunomide results in increased expression of ZFAND3 mRNA24136188
D008628MercuryMercury analog results in decreased expression of ZFAND3 mRNA25056781
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ZFAND3 mRNA26011545
C028007nickel monoxidenickel monoxide results in decreased expression of ZFAND3 mRNA19167457
D012406RoxarsoneRoxarsone results in decreased expression of ZFAND3 protein21652273
D012999SomanSoman results in increased expression of ZFAND3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZFAND3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZFAND3 mRNA19465110
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ZFAND3 protein18951874
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZFAND3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ZFAND3 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of ZFAND3 mRNA22378314
D014520UrethaneUrethane results in increased expression of ZFAND3 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal