Gene: RORA

6095
NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA
RAR related orphan receptor A
protein-coding
15q22.2
Ensembl:ENSG00000069667 MIM:600825 Vega:OTTHUMG00000132769 UniprotKB:P35398
NG_029246.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.147e-1 (AD)  8.551e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11071587chr15:61141344 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21756476chr15:61182765RORA3.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIK3CA0.874
NCOA20.863
COG50.843
SEC24B0.829
PIAS10.82
PIKFYVE0.82
KPNA50.819
KLF120.817
ARHGEF120.817
IREB20.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.471
OR4F29-0.421
TNFRSF13B-0.339
GNG8-0.315
TP73-0.307
FXYD4-0.306
ANXA13-0.293
NANOGNB-0.284
CTNNA3-0.266
TMEM139-0.258

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01990Cholesterol-SulfateSmall MoleculeExperimentalTarget
DB04540CholesterolSmall Molecule57-88-5Approved|Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RORA mRNA28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of RORA mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RORA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RORA mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RORA mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RORA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RORA mRNA]17585979
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RORA mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of RORA mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RORA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RORA mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RORA gene27153756
D013196DihydrotestosteroneDihydrotestosterone promotes the reaction [AR protein binds to RORA promoter]21359227
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of RORA mRNA21359227
D000841AnisomycinAnisomycin results in increased expression of RORA mRNA24247028
D001151ArsenicArsenic affects the methylation of RORA gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of RORA mRNA26705709
C006632arsenic trioxidearsenic trioxide results in increased expression of RORA mRNA15073043
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RORA mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RORA mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RORA mRNA19770486
D004958EstradiolEstradiol affects the expression of RORA mRNA22574217
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to RORA promoter]21359227
D004958EstradiolEstradiol results in decreased expression of RORA mRNA21632981
D004958EstradiolEstradiol results in increased expression of RORA mRNA21359227
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RORA mRNA26496021
C004541biochanin Abiochanin A results in increased activity of RORA protein25583575
C004541biochanin A[biochanin A results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C006780bisphenol Abisphenol A affects the expression of RORA mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RORA mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RORA mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RORA mRNA15336504
D019256Cadmium ChlorideCadmium Chloride affects the expression of RORA mRNA18974090
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RORA mRNA17484886
D002706ChlordanChlordan results in decreased expression of RORA mRNA23153324
D002737ChloropreneChloroprene results in increased expression of RORA mRNA23125180
D002737ChloropreneChloroprene results in increased expression of RORA mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORA gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RORA mRNA17585979
D002994Clofibrate[Clofibrate co-treated with PPARG] results in increased expression of RORA mRNA9543393
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RORA mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of RORA mRNA19320972|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RORA mRNA]22202117
D019327Copper SulfateCopper Sulfate results in increased expression of RORA mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RORA mRNA19770486
C004742daidzeindaidzein results in increased activity of RORA protein25583575
C004742daidzein[daidzein results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of RORA mRNA]21095227
C014347decitabinedecitabine results in increased expression of RORA mRNA16367923
C007262deoxynivalenoldeoxynivalenol results in increased expression of RORA mRNA24247028
D003907DexamethasoneDexamethasone results in increased expression of RORA mRNA19022236
D003907Dexamethasone[Dexamethasone co-treated with INS1 protein] results in increased expression of RORA mRNA9543393
D003907DexamethasoneTGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORA mRNA]9543393
D003907DexamethasoneTNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORA mRNA]9543393
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RORA mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RORA mRNA21266533
D004008DiclofenacDiclofenac results in decreased expression of RORA mRNA26934552
D004041Dietary FatsDietary Fats results in decreased expression of RORA mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of RORA mRNA23537522
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RORA mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of RORA mRNA25242112
D004237DiuronDiuron metabolite results in increased expression of RORA mRNA24172598
C017435enilconazoleenilconazole binds to and results in decreased activity of RORA protein22289359
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RORA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RORA mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RORA mRNA17351261
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RORA mRNA28329830
D005485FlutamideFlutamide results in decreased expression of RORA mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORA gene20938992
C007768formononetinformononetin results in increased activity of RORA protein25583575
C007768formononetin[formononetin results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
D019833GenisteinGenistein results in increased activity of RORA protein25583575
D019833Genistein[Genistein results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C409722hexaconazolehexaconazole binds to and results in decreased activity of RORA protein22289359
D006854HydrocortisoneHydrocortisone results in increased expression of RORA mRNA21980503
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of RORA mRNA"26377693
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RORA mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RORA mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RORA mRNA26387944
D007649KetamineKetamine results in increased expression of RORA mRNA20080153
C045463leflunomideleflunomide results in increased expression of RORA mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RORA mRNA28698385
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RORA protein28698385
D008070LipopolysaccharidesRORA protein affects the susceptibility to Lipopolysaccharides28698385
D008070Lipopolysaccharides[RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of IL1A28698385
D008070Lipopolysaccharides[RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of IL1B28698385
D008070Lipopolysaccharides[RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of TNF28698385
D008550MelatoninMelatonin binds to RORA protein16030176
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORA gene20938992
D008727MethotrexateMethotrexate affects the expression of RORA mRNA18502557
D008752Methylene ChlorideMethylene Chloride results in decreased expression of RORA mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RORA mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of RORA mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of RORA mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RORA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RORA mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RORA mRNA29191790
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RORA mRNA22401849
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of RORA mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RORA mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RORA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RORA mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of RORA mRNA24136188
D009532NickelNickel results in decreased expression of RORA mRNA24768652
C022838nickel chloridenickel chloride results in increased expression of RORA mRNA17312168
D010100OxygenOxygen deficiency results in increased expression of RORA mRNA24236059
D010126OzoneOzone results in increased expression of RORA mRNA25838073
D000073878Palm OilPalm Oil results in decreased expression of RORA mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of RORA mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of RORA mRNA19095052
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RORA mRNA26705709
D010578PetroleumPetroleum affects the expression of RORA mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of RORA mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of RORA mRNA19270015
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of RORA mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RORA mRNA19710929
D010938Plant OilsPlant Oils results in increased expression of RORA mRNA23370395
D011441PropylthiouracilPropylthiouracil results in decreased expression of RORA mRNA24780913
D011794QuercetinQuercetin affects the expression of RORA mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of RORA mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of RORA mRNA25572481
D012715Sesame OilSesame Oil results in increased expression of RORA mRNA29191790
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of RORA mRNA]21095227
C009277sodium arsenatesodium arsenate results in decreased expression of RORA mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of RORA mRNA21795629
D012999SomanSoman results in increased expression of RORA mRNA19281266
C559087SR 1078SR 1078 results in increased expression of RORA mRNA28698385
C559087SR 1078SR 1078 results in increased expression of RORA protein28698385
D020058StyreneStyrene results in decreased expression of RORA mRNA28951217
D013629TamoxifenTamoxifen affects the expression of RORA mRNA17555576
D013629TamoxifenTamoxifen results in decreased activity of RORA protein20937368
C004648testosterone enanthatetestosterone enanthate results in increased expression of RORA mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RORA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RORA mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RORA mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RORA mRNA21215274
C524826tetraconazoletetraconazole binds to and results in decreased activity of RORA protein22289359
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RORA mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of RORA mRNA27188386
C423915TO-901317TO-901317 binds to and results in decreased activity of RORA protein22289359
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of RORA gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RORA mRNA28111298
D014212TretinoinTretinoin results in increased expression of RORA mRNA23724009
C011559tributyltintributyltin results in decreased expression of RORA mRNA27614199
C012589trichostatin Atrichostatin A results in increased expression of RORA mRNA24935251
C053549triflumizoltriflumizol binds to and results in decreased activity of RORA protein22289359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RORA mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RORA mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of RORA mRNA28698385
D014415TunicamycinTunicamycin results in increased expression of RORA protein28698385
D014520UrethaneUrethane results in increased expression of RORA mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RORA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RORA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RORA mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of RORA gene28853863|2915479
D014635Valproic AcidValproic Acid results in increased expression of RORA mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RORA gene25560391
C025643vinclozolinvinclozolin affects the expression of RORA mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of RORA mRNA23555832
C025643vinclozolinvinclozolin results in decreased expression of RORA mRNA22496781
D014750VincristineVincristine results in increased expression of RORA mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of RORA mRNA19244175
C111237vorinostatvorinostat results in decreased expression of RORA mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of RORA mRNA"25208076
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RORA mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA19955433  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA21628546  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001222transcription corepressor binding-IPI9328355  
GO:0001223transcription coactivator binding-IBA21873635  
GO:0001223transcription coactivator binding-IPI9862959  10478845  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003677DNA binding-IDA7926749  9328355  11053433  
GO:0003700DNA-binding transcription factor activity-IDA7926749  9328355  11053433  17545671  18658046  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IEA-  
GO:0005515protein binding-IPI14701856  16713569  22170608  25416956  
GO:0008013beta-catenin binding-IEA-  
GO:0008134transcription factor binding-IPI9862959  18658046  
GO:0008142oxysterol binding-IBA21873635  
GO:0008142oxysterol binding-IDA19965867  
GO:0008270zinc ion binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA11053433  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IDA19965867  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IMP18658046  
GO:0006355regulation of transcription, DNA-templated-IDA9328355  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006805xenobiotic metabolic process-ISS-  
GO:0006809nitric oxide biosynthetic process-IEA-  
GO:0008589regulation of smoothened signaling pathway-ISS-  
GO:0010575positive regulation of vascular endothelial growth factor production-IMP18658046  
GO:0010906regulation of glucose metabolic process-ISS-  
GO:0019218regulation of steroid metabolic process-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0021702cerebellar Purkinje cell differentiation-IEA-  
GO:0021930cerebellar granule cell precursor proliferation-ISS-  
GO:0030522intracellular receptor signaling pathway-IDA19965867  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0036315cellular response to sterol-IDA19965867  
GO:0036315cellular response to sterol-IMP18658046  
GO:0042632cholesterol homeostasis-ISS-  
GO:0042692muscle cell differentiation-IMP9862959  
GO:0042753positive regulation of circadian rhythm-ISS-  
GO:0043030regulation of macrophage activation-IEA-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IMP11252722  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045599negative regulation of fat cell differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA7926749  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17545671  19955433  
GO:0046068cGMP metabolic process-IEA-  
GO:0050728negative regulation of inflammatory response-IBA21873635  
GO:0050728negative regulation of inflammatory response-IMP11252722  
GO:0060850regulation of transcription involved in cell fate commitment-ISS-  
GO:0070328triglyceride homeostasis-IMP11053433  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071456cellular response to hypoxia-IMP18658046  
GO:0072539T-helper 17 cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18658046  19965867  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368082RORA activates gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-168256Immune SystemTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockIEA
R-HSA-400253Circadian ClockTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet
25863981Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles. (2015 Sep)Persson HJ Allergy Clin Immunol
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
23028483Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. (2012)Ramasamy APLoS One
28412756Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
22744720Retinoic acid-related orphan receptor-alpha is induced in the setting of DNA damage and promotes pulmonary emphysema. (2012 Sep 1)Shi YAm J Respir Crit Care Med