Gene: RORB

6096
NR1F2|ROR-BETA|RZR-BETA|RZRB|bA133M9.1
RAR related orphan receptor B
protein-coding
9q21.13
Ensembl:ENSG00000198963 MIM:601972 Vega:OTTHUMG00000020026 UniprotKB:Q92753
NG_046926.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.252e-1 (AD)  5.629e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13293006chr9:74521980 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs10869409chr9:74508473 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs7846903chr9:74500195 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOX0.871
PPM1L0.862
FAM217B0.862
CDH100.859
CPEB30.857
NRXN10.857
MAGI30.854
KCNA20.851
CAMK2G0.851
EFR3A0.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.52
SH2D1A-0.518
EVA1A-0.508
MDFI-0.506
HAS2-0.495
ACAP1-0.493
SGMS2-0.492
BEST3-0.49
C9orf135-0.488
KLF17-0.483

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RORB mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RORB protein20106945
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RORB mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RORB mRNA16483693
C015001arsenitearsenite results in increased methylation of RORB promoter23974009
C547126AZM551248AZM551248 results in decreased expression of RORB mRNA22323515
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of RORB mRNA20660070
D004958EstradiolEstradiol results in decreased expression of RORB mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of RORB mRNA21179406
C006780bisphenol Abisphenol A affects the expression of RORB mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RORB mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RORB mRNA22079614
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RORB mRNA12832660
D002330CarmustineCarmustine affects the expression of RORB mRNA19174181
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORB gene20938992
D003024ClozapineClozapine results in decreased expression of RORB mRNA11564422
D003042CocaineCocaine results in increased expression of RORB mRNA20056891
D003471CuprizoneCuprizone results in increased expression of RORB mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of RORB mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORB gene20938992
D006220HaloperidolHaloperidol results in decreased expression of RORB mRNA11564422
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RORB mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RORB mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RORB gene20938992
D008727MethotrexateMethotrexate results in increased expression of RORB mRNA24449571
C005219methyl cellosolvemethyl cellosolve results in increased expression of RORB mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RORB mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RORB mRNA"20188158
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RORB mRNA"27188386
D010795Phthalic AcidsPhthalic Acids results in increased expression of RORB mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RORB mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of RORB mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of RORB mRNA17404688|2086464
C082026tebufenozidetebufenozide results in increased activity of RORB protein20143881
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of RORB mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RORB mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RORB mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RORB mRNA25613284
D014212TretinoinTretinoin results in decreased expression of RORB mRNA21934132
C032910triadimefontriadimefon results in increased expression of RORB mRNA26705709
C012589trichostatin Atrichostatin A results in increased expression of RORB mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of RORB mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of RORB mRNA24383497|2493525
D014635Valproic AcidValproic Acid affects the expression of RORB mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RORB gene25560391
D015032ZincZinc deficiency results in decreased expression of RORB mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IEA-  
GO:0005515protein binding-IPI23555304  
GO:0008134transcription factor binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0008502melatonin receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-TAS7935491  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007601visual perception-IEA-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0035881amacrine cell differentiation-ISS-  
GO:0042462eye photoreceptor cell development-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045668negative regulation of osteoblast differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046548retinal rod cell development-ISS-  
GO:0046549retinal cone cell development-ISS-  
GO:0048511rhythmic process-IEA-  
GO:0060041retina development in camera-type eye-ISS-  
GO:0071300cellular response to retinoic acid-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28412756Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One