Gene: RPLP2

6181
D11S2243E|LP2|P2|RPP2
ribosomal protein lateral stalk subunit P2
protein-coding
11p15.5
Ensembl:ENSG00000177600 MIM:180530 Vega:OTTHUMG00000133317 UniprotKB:P05387
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.271e-1 (AD)  1.716e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10902222chr11:810882 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPLP10.984
FAU0.98
RPS150.978
RPL350.975
RPS160.974
RPL13A0.974
RPL360.971
RPS280.97
RPS100.969
RPL190.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.793
OR4F5-0.747
NCR3LG1-0.248
PCDHAC1-0.246
HTR3B-0.244
MCHR2-0.243
PPM1E-0.241
RTKN2-0.238
OR14I1-0.238
STARD4-AS1-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of RPLP2 mRNA20566314
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPLP2 mRNA"15215175
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPLP2 mRNA16483693
D001280AtrazineAtrazine results in increased expression of RPLP2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of RPLP2 protein25275270
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPLP2 mRNA16532367
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPLP2 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RPLP2 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of RPLP2 mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of RPLP2 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPLP2 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of RPLP2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of RPLP2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPLP2 mRNA28628672
D002104CadmiumCadmium results in decreased expression of RPLP2 mRNA alternative form20447699
D002104CadmiumCadmium results in increased expression of RPLP2 mRNA20447699
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RPLP2 mRNA27339419
C099555CD 437CD 437 results in decreased expression of RPLP2 mRNA12958071
C100187chloropicrinchloropicrin affects the expression of RPLP2 mRNA26352163
D003024ClozapineClozapine results in increased expression of RPLP2 mRNA14647396
D016572CyclosporineCyclosporine results in increased expression of RPLP2 mRNA20106945
C014347decitabinedecitabine results in increased expression of RPLP2 mRNA27915011
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of RPLP2 protein23352502
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of RPLP2 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPLP2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPLP2 mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of RPLP2 mRNA19030233
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RPLP2 mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of RPLP2 mRNA16002434
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPLP2 mRNA16532367
D004317DoxorubicinDoxorubicin affects the expression of RPLP2 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPLP2 protein23301498
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of RPLP2 mRNA22406618
D005485FlutamideFlutamide results in increased expression of RPLP2 mRNA24136188
C039281furanfuran results in increased methylation of RPLP2 gene22079235
D005897GlafenineGlafenine results in increased expression of RPLP2 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of RPLP2 mRNA22634610
C010974glyphosateglyphosate results in decreased expression of RPLP2 mRNA15654877
C010974glyphosateglyphosate results in increased expression of RPLP2 mRNA16532367
D006220HaloperidolHaloperidol results in increased expression of RPLP2 mRNA14647396
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of RPLP2 mRNA20566314
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPLP2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPLP2 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of RPLP2 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPLP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPLP2 mRNA28628672
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPLP2 mRNA16532367
C544151jinfukangjinfukang results in increased expression of RPLP2 mRNA27392435
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of RPLP2 mRNA20039754
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in increased expression of RPLP2 mRNA21487212
C051752nefazodonenefazodone results in increased expression of RPLP2 mRNA24136188
D010100OxygenOxygen deficiency results in increased expression of RPLP2 mRNA24205000
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of RPLP2 protein19954255
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of RPLP2 mRNA22406618
D026023PermethrinPermethrin results in decreased expression of RPLP2 mRNA22406618
C058305phenethyl isothiocyanateRPLP2 protein binds to phenethyl isothiocyanate21838287
D011441PropylthiouracilPropylthiouracil results in increased expression of RPLP2 mRNA24780913
C059514resveratrolresveratrol results in increased expression of RPLP2 mRNA22610192
D018038Sodium SeleniteSodium Selenite results in increased expression of RPLP2 mRNA18175754
D013605T-2 ToxinT-2 Toxin affects the expression of RPLP2 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPLP2 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPLP2 mRNA20385220
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPLP2 protein20385220
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of RPLP2 mRNA18422935
D014635Valproic AcidValproic Acid results in increased expression of RPLP2 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003735structural constituent of ribosome-IDA3323886  
GO:0003735structural constituent of ribosome-NAS12962325  
GO:0005515protein binding-IPI22135285  
GO ID GO Term Qualifier Evidence PubMed
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0006412translation-NAS12962325  
GO:0006413translational initiation-TAS-  
GO:0006414translational elongation-IEA-  
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0022625cytosolic large ribosomal subunit-HDA12962325  
GO:0022625cytosolic large ribosomal subunit-IDA3323886  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa03010Ribosome
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismIEA
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationIEA
R-HSA-1643685DiseaseTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-192823Viral mRNA TranslationTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72312rRNA processingTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72764Eukaryotic Translation TerminationIEA
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal