Gene: RPS3

6188
S3
ribosomal protein S3
protein-coding
11q13.4
Ensembl:ENSG00000149273 MIM:600454 Vega:OTTHUMG00000165448 UniprotKB:P23396
NC_000011.10
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.039e-1 (AD)  2.577e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3018100chr11:75417295 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26039141chr11:75113160RPS31.380e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL110.977
RPS80.976
RPS160.969
RPL27A0.968
RPL320.967
RPL100.967
RPL18A0.965
RPS50.965
RPL190.964
RPL13A0.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.741
OR4F5-0.692
PCDHAC1-0.255
OTOGL-0.241
FREM3-0.236
NXPH2-0.235
PLEKHD1-0.235
FBLN7-0.235
ADRA1D-0.232
RTKN2-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RPS3 mRNA"19114083
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in increased expression of RPS3 mRNA"11227219
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS3 mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of RPS3 mRNA"20206263
C0194992-nitrofluorene2-nitrofluorene results in increased expression of RPS3 mRNA15890375
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA]"11179685
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS3 mRNA15890375
C0415944-nonylphenol4-nonylphenol results in increased expression of RPS3 mRNA22609975
C0415944-nonylphenol4-nonylphenol affects the expression of RPS3 mRNA15792627
D000082AcetaminophenAcetaminophen affects the expression of RPS3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of RPS3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RPS3 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RPS3 mRNA15890375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPS3 mRNA16483693
C028559bathocuproine sulfonatebathocuproine sulfonate results in decreased expression of RPS3 mRNA16973896
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RPS3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPS3 mRNA20504355|2222880
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA]"11179685
D004958EstradiolEstradiol results in increased expression of RPS3 mRNA11179685
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA]11179685
C006780bisphenol Abisphenol A results in increased expression of RPS3 mRNA22609975
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS3 mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of RPS3 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of RPS3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS3 mRNA28628672
C013418bromfenacoumbromfenacoum results in decreased expression of RPS3 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RPS3 mRNA18409656
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of RPS3 mRNA21075942
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RPS3 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of RPS3 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of RPS3 mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RPS3 mRNA28472532
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of RPS3 mRNA16488489
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS3 mRNA17602206
D003300CopperCopper results in increased expression of RPS3 mRNA18522721
D019327Copper SulfateCopper Sulfate results in decreased expression of RPS3 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of RPS3 protein25470785
D003520CyclophosphamideCyclophosphamide results in decreased expression of RPS3 mRNA11906922
D016572CyclosporineCyclosporine results in increased expression of RPS3 mRNA20106945
C093628cyproconazolecyproconazole affects the expression of RPS3 mRNA21621602
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS3 mRNA28628672
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of RPS3 mRNA22609975
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS3 mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RPS3 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RPS3 mRNA15890375
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPS3 protein23301498
D000431EthanolEthanol results in decreased expression of RPS3 protein19609968
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RPS3 mRNA17475347
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RPS3 mRNA17555576
C034096ethoxyacetic acidethoxyacetic acid affects the expression of RPS3 mRNA21621602
D005273FenbendazoleFenbendazole results in increased expression of RPS3 mRNA22609975
C061365flusilazoleflusilazole affects the expression of RPS3 mRNA21621602
D005485FlutamideFlutamide results in increased expression of RPS3 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of RPS3 mRNA22061828
D005897GlafenineGlafenine results in increased expression of RPS3 mRNA24136188
D017313FenretinideFenretinide results in increased expression of RPS3 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS3 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of RPS3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS3 mRNA28628672
C544151jinfukangjinfukang results in increased expression of RPS3 mRNA27392435
D007854LeadLead affects the expression of RPS3 mRNA28903495
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of RPS3 mRNA21075942
D008701MethapyrileneMethapyrilene results in increased expression of RPS3 mRNA15890375
C013598methoxyacetic acidmethoxyacetic acid affects the expression of RPS3 mRNA21621602
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of RPS3 mRNA20039754
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RPS3 protein26558463
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of RPS3 mRNA21075942
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to RPS3 protein]17220478
C051752nefazodonenefazodone results in increased expression of RPS3 mRNA24136188
D009532NickelMT1 affects the reaction [Nickel affects the expression of RPS3 mRNA]16166738
D009532NickelMT2 affects the reaction [Nickel affects the expression of RPS3 mRNA]16166738
C012655nimesulidenimesulide results in increased expression of RPS3 mRNA24136188
C016340o,p'-DDT"o,p'-DDT affects the expression of RPS3 mRNA"17984292
D052638Particulate MatterParticulate Matter results in decreased expression of RPS3 mRNA24769257
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of RPS3 mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RPS3 protein26879310
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of RPS3 mRNA21621602
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of RPS3 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of RPS3 mRNA15890375
D012402RotenoneRotenone results in increased expression of RPS3 mRNA19013527
C016104sodium bichromatesodium bichromate results in increased expression of RPS3 mRNA22561333
D018038Sodium SeleniteSodium Selenite results in increased expression of RPS3 mRNA18175754
D013311StreptozocinStreptozocin results in increased expression of RPS3 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of RPS3 mRNA]16684804
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of RPS3 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPS3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RPS3 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RPS3 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPS3 protein16548065
D014212TretinoinTretinoin results in decreased expression of RPS3 mRNA23724009
D014520UrethaneUrethane results in increased expression of RPS3 mRNA28818685
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of RPS3 mRNA]16684804
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of RPS3 mRNA21503142
C025643vinclozolinvinclozolin results in decreased expression of RPS3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingcontributes_toIMP18045535  
GO:0003677DNA binding-IDA18610840  
GO:0003684damaged DNA binding-IBA21873635  
GO:0003684damaged DNA binding-IDA14706345  16737853  17560175  18610840  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA20217897  
GO:0003729mRNA binding-IDA18464793  
GO:0003735structural constituent of ribosome-HDA15883184  
GO:0003735structural constituent of ribosome-IBA21873635  
GO:0003735structural constituent of ribosome-NAS1712897  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IDA7775413  15707971  16737853  18610840  19059439  
GO:0004520endodeoxyribonuclease activity-IDA15707971  20605787  
GO:0005515protein binding-IPI15161933  18045535  18274552  19656744  20041225  20618440  
21146485  21399639  22244329  22510408  23911537  24423872  
24457201  24725412  24965446  25609649  26526615  28065601  
28132843  
GO:0008017microtubule binding-IDA23131551  
GO:0008134transcription factor binding-IPI20605787  
GO:0008534oxidized purine nucleobase lesion DNA N-glycosylase activity-IBA21873635  
GO:0015631tubulin binding-IDA23131551  
GO:0019104DNA N-glycosylase activityNOTIDA18610840  
GO:0019104DNA N-glycosylase activityNOTTAS15707971  
GO:0019899enzyme binding-IPI15518571  18973764  19460357  
GO:0019900kinase binding-IPI19059439  20605787  
GO:0019901protein kinase binding-IPI15950189  21871177  
GO:0030544Hsp70 protein binding-IDA23911537  
GO:0032357oxidized purine DNA binding-IBA21873635  
GO:0032357oxidized purine DNA binding-IDA14706345  
GO:0032358oxidized pyrimidine DNA binding-IDA19656744  
GO:0044390ubiquitin-like protein conjugating enzyme binding-IPI21968017  
GO:0044877protein-containing complex binding-IMP18045535  
GO:0051018protein kinase A binding-IPI16814409  
GO:0051536iron-sulfur cluster binding-NAS11911468  
GO:0051879Hsp90 protein binding-IDA23911537  
GO:0070181small ribosomal subunit rRNA binding-IDA18610840  
GO:0097100supercoiled DNA binding-IDA15707971  
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006412translation-IC8706699  
GO:0006412translation-NAS1712897  
GO:0006413translational initiation-NAS15883184  
GO:0006413translational initiation-TAS-  
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0006974cellular response to DNA damage stimulus-IEP17560175  
GO:0006979response to oxidative stress-IDA23911537  
GO:0007059chromosome segregation-IMP23131551  
GO:0010628positive regulation of gene expression-IMP20605787  
GO:0017148negative regulation of translation-IDA20217897  
GO:0031116positive regulation of microtubule polymerization-IMP23131551  
GO:0031334positive regulation of protein complex assembly-IMP18045535  
GO:0031397negative regulation of protein ubiquitination-IDA19656744  
GO:0032079positive regulation of endodeoxyribonuclease activity-IDA18973764  
GO:0032743positive regulation of interleukin-2 production-IMP18045535  
GO:0042104positive regulation of activated T cell proliferation-IMP18045535  
GO:0042769DNA damage response, detection of DNA damage-IDA23911537  
GO:0042769DNA damage response, detection of DNA damage-IMP22510408  
GO:0042981regulation of apoptotic process-IMP20605787  
GO:0043507positive regulation of JUN kinase activity-IMP22510408  
GO:0045738negative regulation of DNA repair-IMP17049931  
GO:0045739positive regulation of DNA repair-IBA21873635  
GO:0045739positive regulation of DNA repair-IDA23911537  
GO:0050862positive regulation of T cell receptor signaling pathway-IMP18045535  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IGI18045535  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP18045535  
GO:0051225spindle assembly-IMP23131551  
GO:0051301cell division-IEA-  
GO:0061481response to TNF agonist-IDA20041225  
GO:0070301cellular response to hydrogen peroxide-IDA23911537  
GO:0071356cellular response to tumor necrosis factor-IMP18045535  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA20041225  
GO:1902231positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage-IMP22510408  
GO:1902546positive regulation of DNA N-glycosylase activity-IDA15518571  
GO:1905053positive regulation of base-excision repair-IDA18973764  
GO:2001235positive regulation of apoptotic signaling pathway-IBA21873635  
GO:2001235positive regulation of apoptotic signaling pathway-IDA14988002  
GO:2001272positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis-IMP22510408  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA14988002  16814409  17560175  18045535  19059439  19460357  20041225  
GO:0005634nucleus-IMP21399639  21871177  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA19460357  
GO:0005737cytoplasm-IDA14988002  19059439  20217897  
GO:0005737cytoplasm-IMP21871177  
GO:0005743mitochondrial inner membrane-IDA23911537  
GO:0005759mitochondrial matrix-IDA23911537  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-IDA16814409  17560175  18045535  
GO:0005829cytosol-TAS-  
GO:0005840ribosome-IDA19059439  19460357  20217897  
GO:0005844polysome-IDA19460357  
GO:0005886plasma membrane-IDA22510408  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA19946888  
GO:0022627cytosolic small ribosomal subunit-HDA15883184  
GO:0022627cytosolic small ribosomal subunit-IBA21873635  
GO:0022627cytosolic small ribosomal subunit-IDA8706699  
GO:0032587ruffle membrane-IDA16814409  
GO:0070062extracellular exosome-HDA20458337  
GO:0071159NF-kappaB complex-IDA18045535  
GO:0072686mitotic spindle-IDA23131551  
GO:1990904ribonucleoprotein complex-IDA17289661  
KEGG ID KEGG Term
hsa03010Ribosome
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismIEA
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationIEA
R-HSA-1643685DiseaseTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-192823Viral mRNA TranslationTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72312rRNA processingTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72649Translation initiation complex formationTAS
R-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43STAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72695Formation of the ternary complex, and subsequently, the 43S complexTAS
R-HSA-72702Ribosomal scanning and start codon recognitionTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72764Eukaryotic Translation TerminationIEA
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal