Gene: RSU1

6251
RSP-1
Ras suppressor protein 1
protein-coding
10p13
Ensembl:ENSG00000148484 MIM:179555 Vega:OTTHUMG00000017740 UniprotKB:Q15404
NC_000010.11
SNP Mapped
1   ANCO-SNPs
CD
0   
2.201e-1 (AD)  1.730e-1 (ND)   (Frontal_Cortex)
1.544e-2 (AD)  5.589e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs115664995chr10:16796593 (GRCh38.p7)G>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMBIM40.851
MCMBP0.833
CD1640.827
TMED100.824
PSME10.822
SEC11A0.819
WDR10.817
CTNNA10.811
ARFIP10.809
PABPC10.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.614
C14orf180-0.195
ABCC12-0.186
NKX6-3-0.183
OPRD1-0.183
ADRA1D-0.181
KRTAP5-8-0.176
ATP12A-0.174
SSX5-0.167

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RSU1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of RSU1 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RSU1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RSU1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RSU1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RSU1 mRNA19770486
C006632arsenic trioxidearsenic trioxide results in decreased expression of RSU1 mRNA26705709
C015001arsenitearsenite results in increased methylation of RSU1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RSU1 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RSU1 mRNA22228805
D004958EstradiolEstradiol affects the expression of RSU1 mRNA23557687
D004958EstradiolEstradiol results in decreased expression of RSU1 mRNA19167446
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RSU1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RSU1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RSU1 gene28505145
D000069286BortezomibBortezomib results in increased expression of RSU1 mRNA20977926
C584509C646 compoundC646 compound results in increased expression of RSU1 mRNA26191083
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of RSU1 protein"23026733
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RSU1 mRNA23650126
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of RSU1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of RSU1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of RSU1 mRNA20106945|2556210
D003634DDTDDT results in increased expression of RSU1 protein15619295
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RSU1 mRNA28628672
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of RSU1 mRNA21858171
D004041Dietary FatsDietary Fats results in increased expression of RSU1 mRNA19030233
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RSU1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RSU1 mRNA23649840
C052034fenoxycarbfenoxycarb results in increased expression of RSU1 mRNA27553699
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RSU1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RSU1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RSU1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RSU1 mRNA23086925
D048628KetolidesKetolides analog results in increased expression of RSU1 mRNA24967691
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RSU1 mRNA23649840
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of RSU1 protein"23026733
D009532NickelNickel results in decreased expression of RSU1 mRNA12540486
D010795Phthalic AcidsPhthalic Acids results in decreased expression of RSU1 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of RSU1 mRNA21061450
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of RSU1 mRNA21858171
D012969Sodium FluorideSodium Fluoride results in decreased expression of RSU1 protein28918527
D013629TamoxifenTamoxifen affects the expression of RSU1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RSU1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RSU1 mRNA25613284
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RSU1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RSU1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RSU1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of RSU1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of RSU1 mRNA21126777
C025643vinclozolinvinclozolin affects the expression of RSU1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  20926685  23414517  23455922  25416956  25852190  
26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS1508180  
GO:0010810regulation of cell-substrate adhesionNOTIMP20926685  
GO:0010811positive regulation of cell-substrate adhesion-IMP20926685  
GO:0043547positive regulation of GTPase activity-IMP20926685  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-IDA20926685  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446388Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal