Gene: RYR2

6262
ARVC2|ARVD2|RYR-2|RyR|VTSIP
ryanodine receptor 2
protein-coding
1q43
Ensembl:ENSG00000198626 MIM:180902 Vega:OTTHUMG00000039543 UniprotKB:Q92736
NG_008799.2
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.748e-1 (AD)  8.101e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12737847chr1:237782570 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10495392chr1:237259689 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKI0.955
PCLO0.951
SAMD120.944
HERC10.943
LMO70.94
AAK10.939
ATP8A20.939
ERC20.938
NBEA0.938
IPCEF10.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.601
RAB13-0.594
YES1-0.573
ASB4-0.572
RNF135-0.57
MYL3-0.567
HEY2-0.565
MAPKAPK3-0.558
MDFI-0.543
S100A16-0.542

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB09085TetracaineSmall Molecule94-24-6ApprovedTarget
ID Drug Name Action PubMed
C0329042,2',3,5',6-pentachlorobiphenyl"RYR2 protein results in increased susceptibility to 2,2',3,5',6-pentachlorobiphenyl"22534141
C0104982,3,6,2',3',6'-hexachlorobiphenyl"2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR2 protein]"18954145
C4861822,3-bis(4-hydroxyphenyl)-propionitrile"2,3-bis(4-hydroxyphenyl)-propionitrile results in increased phosphorylation of RYR2 protein"25723814
C5562954-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RYR2 protein]"25723814
C065380A 68930A 68930 results in increased expression of RYR2 protein22504960
C065380A 68930Baclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein]22504960
D000082AcetaminophenAcetaminophen affects the expression of RYR2 mRNA17562736
D000255Adenosine TriphosphateCaffeine promotes the reaction [RYR2 protein results in increased secretion of Adenosine Triphosphate]18446524
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RYR2 gene27153756
D001151ArsenicArsenic affects the methylation of RYR2 gene25304211
D001262AtenololAtenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]12743001
D001262AtenololAtenolol results in increased activity of RYR2 protein12743001
D001418BaclofenBaclofen inhibits the reaction [A 68930 results in increased expression of RYR2 protein]22504960
D001418BaclofenBaclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]22504960
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RYR2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RYR2 gene25435355
D004958EstradiolEstradiol results in decreased expression of RYR2 mRNA20068009
D001640BicucullineRYR2 results in increased susceptibility to Bicuculline22534176
C543008bis(4-hydroxyphenyl)sulfone"4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RYR2 protein]"25723814
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased phosphorylation of RYR2 protein25723814
C006780bisphenol Abisphenol A results in increased expression of RYR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased phosphorylation of RYR2 protein28324061
D002110CaffeineCaffeine promotes the reaction [RYR2 protein results in increased abundance of Calcium]18446524
D002110CaffeineCaffeine promotes the reaction [RYR2 protein results in increased secretion of Adenosine Triphosphate]18446524
D002110CaffeineCaffeine results in increased activity of RYR2 protein18446524
D002110CaffeineDantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002110CaffeineHOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002118CalciumCaffeine promotes the reaction [RYR2 protein results in increased abundance of Calcium]18446524
D002118CalciumFKBP1A protein inhibits the reaction [Calcium results in increased activity of RYR2 protein]17872463
D002118CalciumCalcium results in increased activity of RYR2 protein17872463
D002118CalciumDantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002118CalciumHOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002118CalciumHOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
C081643candesartancandesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]16723803
C043211carvedilolcarvedilol results in decreased oxidation of and results in increased stability of RYR2 protein17448375
C043211carvedilolcarvedilol affects the activity of RYR2 protein21743453
C043211carvedilolcarvedilol analog affects the activity of RYR2 protein21743453
C043211carvedilolcarvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]21743453
C043211carvedilolcarvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein]12743001
C043211carvedilolcarvedilol results in increased activity of RYR2 protein12743001
C043211carvedilolcarvedilol results in increased expression of RYR2 mRNA21924056
C043211carvedilol[Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA21924056
C043211carvedilolcarvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]19620082
C043211carvedilolcarvedilol results in increased expression of RYR2 protein19620082
C043211carvedilolPerindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]19620082
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of RYR2 protein16309888|1933751
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene20938992
D003042CocaineCocaine results in increased expression of RYR2 mRNA21113126
D003042CocaineCocaine affects the expression of RYR2 mRNA20187946
D003471CuprizoneCuprizone results in decreased expression of RYR2 mRNA26577399
D036563Cyclic ADP-RiboseHOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D003620DantroleneDantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D003630DaunorubicinDaunorubicin results in decreased expression of RYR2 mRNA26537877|2894005
D003630DaunorubicinDaunorubicin results in decreased expression of RYR2 mRNA10960060
D003630DaunorubicinDaunorubicin results in increased expression of RYR2 protein26328012
D003630DaunorubicinRazoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA]10960060
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of RYR2 mRNA20920545
D004317DoxorubicinDoxorubicin results in decreased expression of RYR2 mRNA26537877|2894005
D004317DoxorubicinDoxorubicin inhibits the reaction [Ryanodine binds to RYR2 protein]16244372
D004317DoxorubicinDoxorubicin results in decreased expression of RYR2 mRNA16244372
D004317DoxorubicinDoxorubicin results in decreased expression of RYR2 protein16244372
D004317DoxorubicinDoxorubicin results in decreased expression of RYR2 mRNA19915844
D004837EpinephrineEpinephrine results in decreased expression of RYR2 mRNA19300450
D005485FlutamideFlutamide inhibits the reaction [CD38 gene mutant form results in increased expression of RYR2 mRNA]21840325
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene20938992
D004397FonofosFonofos results in increased methylation of RYR2 promoter22847954
D005839GentamicinsGentamicins results in decreased expression of RYR2 mRNA22061828
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of RYR2 mRNA23903933
C027492Huang Qi[Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA21924056
D007545Isoproterenolcarvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]21743453
D007545IsoproterenolIsoproterenol results in increased phosphorylation of RYR2 protein21743453
D007545Isoproterenolcandesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]16723803
D007545IsoproterenolIsoproterenol results in increased phosphorylation of RYR2 protein16723803
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RYR2 mRNA26752646
C109183K201 compoundK201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]20080988
C002385linsidominelinsidomine results in increased oxidation of RYR2 protein28086193
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RYR2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RYR2 mRNA28001369
D008790MetoprololMetoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein]12743001
D008790MetoprololMetoprolol results in increased activity of RYR2 protein12743001
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in decreased expression of RYR2 mRNA]27264040
D008942MitoxantroneMitoxantrone results in decreased expression of RYR2 mRNA26537877|2894005
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of RYR2 protein27495954
C028007nickel monoxidenickel monoxide results in decreased expression of RYR2 mRNA19167457
D009538NicotineCHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]21113126
D009538NicotineNicotine results in increased expression of RYR2 mRNA21113126
D009538NicotineCREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]21113126
D009538NicotineNicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]21113126
D009538NicotineNicotine results in increased expression of RYR2 mRNA21113126
D009538NicotineNicotine results in increased expression of RYR2 protein21113126
D010100OxygenOxygen deficiency results in decreased expression of RYR2 mRNA25937560
D010100OxygenTrimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA]25937560
D010269ParaquatParaquat results in increased expression of RYR2 mRNA22563483
D010278ParathionParathion results in increased methylation of RYR2 promoter22847954
D020913Perindoprilcarvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]19620082
D020913PerindoprilPerindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]19620082
D020913PerindoprilPerindopril results in increased expression of RYR2 protein19620082
D010672PhenytoinPhenytoin results in increased expression of RYR2 mRNA20345932
D010852PicrotoxinPicrotoxin results in increased expression of RYR2 mRNA21113126
D011374ProgesteroneProgesterone results in increased expression of RYR2 mRNA23018184
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in decreased expression of RYR2 mRNA]27264040
D011374ProgesteroneProgesterone results in decreased expression of RYR2 mRNA27264040
D011374ProgesteroneProgesterone results in increased expression of RYR2 mRNA20726854
D015742PropofolPropofol results in decreased phosphorylation of RYR2 protein27495954
D011441PropylthiouracilPropylthiouracil results in decreased expression of RYR2 mRNA24780913
D011929RazoxaneRazoxane inhibits the reaction [Daunorubicin results in decreased expression of RYR2 mRNA]10960060
C059514resveratrolresveratrol results in decreased expression of RYR2 mRNA22610192
C059514resveratrolresveratrol results in increased expression of RYR2 protein25425099
D012433RyanodineRyanodine binds to RYR2 protein11278295
D012433RyanodineDoxorubicin inhibits the reaction [Ryanodine binds to RYR2 protein]16244372
D012433Ryanodine"2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR2 protein]"18954145
D012433RyanodineRyanodine binds to RYR2 protein11278295
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]22504960
D019821SimvastatinSimvastatin results in increased expression of RYR2 mRNA15916736
D019821SimvastatinSimvastatin results in increased expression of RYR2 protein15916736
C071262SK&F 82958Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]22504960
C071262SK&F 82958SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein]22504960
C071262SK&F 82958SK&F 82958 results in increased expression of RYR2 protein22504960
C017947sodium arsenitesodium arsenite affects the methylation of RYR2 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of and affects the splicing of RYR2 mRNA25879800
D013311StreptozocinStreptozocin results in decreased activity of RYR2 protein16685413
D010042OuabainK201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]20080988
D010042OuabainRYR2 mutant form results in increased susceptibility to Ouabain20080988
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of RYR2 mRNA16214533
C012568terbufosterbufos results in increased methylation of RYR2 promoter22847954
D013792ThalidomideThalidomide results in decreased expression of RYR2 mRNA26006729|2621778
C009495titanium dioxidetitanium dioxide affects the expression of RYR2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RYR2 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in decreased expression of RYR2 mRNA18411232
D014292TrimetazidineTrimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA]25937560
D017974Uranium CompoundsUranium Compounds results in decreased expression of RYR2 mRNA19654044
D014635Valproic AcidValproic Acid results in increased methylation of RYR2 gene29154799
C025643vinclozolinvinclozolin affects the expression of RYR2 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of RYR2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005219ryanodine-sensitive calcium-release channel activity-IBA21873635  
GO:0005219ryanodine-sensitive calcium-release channel activity-IDA17921453  
GO:0005219ryanodine-sensitive calcium-release channel activity-TAS-  
GO:0005262calcium channel activity-ISS-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein binding-IPI10830164  11237759  17921453  20195357  23233753  
GO:0005516calmodulin binding-IDA22067155  26164367  27516456  
GO:0005516calmodulin binding-IMP19220289  
GO:0005516calmodulin binding-IPI23040497  
GO:0005516calmodulin binding-ISS-  
GO:0015278calcium-release channel activity-IDA17921453  
GO:0015278calcium-release channel activity-ISS-  
GO:0019899enzyme binding-IPI16213210  
GO:0034236protein kinase A catalytic subunit binding-IDA10830164  
GO:0034237protein kinase A regulatory subunit binding-IDA10830164  
GO:0042802identical protein binding-IPI10830164  
GO:0043621protein self-association-IEA-  
GO:0043924suramin binding-IMP19220289  
GO:0044325ion channel binding-ISS-  
GO:0048763calcium-induced calcium release activity-IBA21873635  
GO:0048763calcium-induced calcium release activity-IDA17921453  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-ISS-  
GO:0002027regulation of heart rate-IMP11159936  12919952  15197150  
GO:0003143embryonic heart tube morphogenesis-ISS-  
GO:0003220left ventricular cardiac muscle tissue morphogenesis-ISS-  
GO:0003300cardiac muscle hypertrophy-ISS-  
GO:0005513detection of calcium ion-IDA10830164  
GO:0006816calcium ion transport-IDA17921453  
GO:0006874cellular calcium ion homeostasis-ISS-  
GO:0010460positive regulation of heart rate-ISS-  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-IC19220289  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-ISS-  
GO:0010882regulation of cardiac muscle contraction by calcium ion signaling-IMP17875969  
GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-IMP12919952  
GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-ISS-  
GO:0014850response to muscle activity-IMP17875969  
GO:0019722calcium-mediated signaling-ISS-  
GO:0030509BMP signaling pathway-IEA-  
GO:0031000response to caffeine-IDA17921453  
GO:0034220ion transmembrane transport-TAS-  
GO:0035584calcium-mediated signaling using intracellular calcium source-IDA17921453  
GO:0035994response to muscle stretch-IMP15105296  
GO:0051209release of sequestered calcium ion into cytosol-IBA21873635  
GO:0051209release of sequestered calcium ion into cytosol-IDA12443530  17921453  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0051284positive regulation of sequestering of calcium ion-IDA12443530  12919952  
GO:0051480regulation of cytosolic calcium ion concentration-ISS-  
GO:0051775response to redox state-IDA19226252  
GO:0055117regulation of cardiac muscle contraction-IMP11159936  
GO:0060048cardiac muscle contraction-IMP10830164  
GO:0060070canonical Wnt signaling pathway-IEA-  
GO:0060402calcium ion transport into cytosol-IDA17921453  
GO:0070296sarcoplasmic reticulum calcium ion transport-TAS19095005  
GO:0071313cellular response to caffeine-IDA12919952  
GO:0071313cellular response to caffeine-ISS-  
GO:0071872cellular response to epinephrine stimulus-ISS-  
GO:0071872cellular response to epinephrine stimulus-TAS23507255  
GO:0072599establishment of protein localization to endoplasmic reticulum-IDA12443530  
GO:0086005ventricular cardiac muscle cell action potential-ISS-  
GO:0086029Purkinje myocyte to ventricular cardiac muscle cell signaling-ISS-  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-IC-  
GO:0097050type B pancreatic cell apoptotic process-IMP15044459  
GO:0098735positive regulation of the force of heart contraction-IMP15105296  
GO:0098904regulation of AV node cell action potential-IMP17875969  
GO:0098907regulation of SA node cell action potential-IMP17875969  
GO:0098910regulation of atrial cardiac muscle cell action potential-IMP17875969  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP17875969  
GO:1901896positive regulation of calcium-transporting ATPase activity-IDA12443530  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005790smooth endoplasmic reticulum-IBA21873635  
GO:0005790smooth endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0014701junctional sarcoplasmic reticulum membrane-TAS17569730  
GO:0016020membrane-IDA12443530  
GO:0016529sarcoplasmic reticulum-IDA10830164  12919952  
GO:0030018Z disc-IBA21873635  
GO:0030018Z disc-IDA19131648  
GO:0030018Z disc-ISS-  
GO:0030659cytoplasmic vesicle membrane-IBA21873635  
GO:0032991protein-containing complex-IDA18468998  
GO:0033017sarcoplasmic reticulum membrane-IBA21873635  
GO:0033017sarcoplasmic reticulum membrane-ISS-  
GO:0033017sarcoplasmic reticulum membrane-TAS19095005  
GO:0034704calcium channel complex-IBA21873635  
GO:0034704calcium channel complex-IDA10830164  16213210  
GO:0042383sarcolemma-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04260Cardiac muscle contraction
hsa04972Pancreatic secretion
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal