Gene: PKNOX2

63876
PREP2
PBX/knotted 1 homeobox 2
protein-coding
11q24.2
Ensembl:ENSG00000165495 MIM:613066 Vega:OTTHUMG00000165884 UniprotKB:Q96KN3
NC_000011.10
PubMed|SNP Mapped
7   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.739e-4 (AD)  4.723e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12284594chr11:125309957 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10893366chr11:125308507 (GRCh38.p7)C>Talcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)
rs10893365chr11:125306541 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs750338chr11:125302697 (GRCh38.p7)A>Galcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)
rs11602925chr11:125301535 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11220015chr11:125301478 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1426153chr11:125300743 (GRCh38.p7)A>Galcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN30.947
SV2A0.941
SLC8A20.938
AP3B20.938
ABCG40.937
STXBP10.937
GABBR20.936
LRRC40.936
R3HDM10.934
COL26A10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.553
RAI14-0.525
YES1-0.517
OR4F5-0.505
HEY2-0.502
WWTR1-0.49
SH2D1A-0.485
SGMS2-0.482
CNN2-0.479
MBNL3-0.476

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKNOX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PKNOX2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PKNOX2 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKNOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PKNOX2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PKNOX2 mRNA17562736
D001151ArsenicArsenic affects the methylation of PKNOX2 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PKNOX2 protein]26598702
C006780bisphenol Abisphenol A results in decreased expression of PKNOX2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PKNOX2 gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of PKNOX2 mRNA19925653
D002330CarmustineCarmustine results in decreased expression of PKNOX2 mRNA16005536
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PKNOX2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of PKNOX2 mRNA23125180
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PKNOX2 mRNA18355967
D003907DexamethasoneDexamethasone results in increased expression of PKNOX2 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PKNOX2 mRNA28962523
D002117CalcitriolCalcitriol results in decreased expression of PKNOX2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PKNOX2 mRNA21592394
D004221DisulfiramDisulfiram results in decreased expression of PKNOX2 mRNA20530235
C118739entinostatentinostat results in increased expression of PKNOX2 mRNA27188386
C000625835HFPO2 compoundHFPO2 compound results in increased expression of PKNOX2 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of PKNOX2 mRNA27553808
C042720mercuric bromidemercuric bromide results in decreased expression of PKNOX2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKNOX2 mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of PKNOX2 mRNA16005536
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of PKNOX2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PKNOX2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PKNOX2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PKNOX2 mRNA"25554681
D009532NickelNickel results in decreased expression of PKNOX2 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PKNOX2 mRNA27935865
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKNOX2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PKNOX2 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PKNOX2 mRNA27935865
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PKNOX2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PKNOX2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of PKNOX2 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PKNOX2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of PKNOX2 mRNA23221170
D012834SilverSilver results in increased expression of PKNOX2 mRNA27131904
D053260SootSoot results in decreased expression of PKNOX2 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PKNOX2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PKNOX2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKNOX2 mRNA21570461|2405805
D013866ThioguanineThioguanine results in decreased expression of PKNOX2 mRNA16005536
D013893ThiramThiram results in decreased expression of PKNOX2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PKNOX2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of PKNOX2 mRNA18230668|2053023
D014635Valproic AcidValproic Acid affects the expression of PKNOX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PKNOX2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of PKNOX2 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKNOX2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PKNOX2 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003785actin monomer binding-IEA-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0015629actin cytoskeleton-IEA-  
GO:0015630microtubule cytoskeleton-IEA-  
GO:0045171intercellular bridge-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (2011 Nov)Wang KSJ Psychiatr Res
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict