Gene info: ID 639

Gene: PRDM1

GENE ID: 639

Synonyms: BLIMP1|PRDI-BF1

Description: PR/SET domain 1

Gene type: protein-coding

Location: 6q21

dbXrefs: Ensembl:ENSG00000057657 MIM:603423 Vega:OTTHUMG00000015299 UniprotKB:O75626

RefSeq: NG_029115.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.258e-1 (AD) 3.519e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6923608	chr6:106089915 (GRCh38.p7)	G>A / G>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14359052	chr6:106546744	PRDM1		4.010e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
APOLD1	0.661
SIK1	0.65
BTG2	0.648
B4GALT1	0.642
CLEC1A	0.62
NEDD9	0.618
THBD	0.606
CSRNP1	0.604
GPR132	0.599
FOXF1	0.592

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RBM34	-0.235
C10orf95	-0.206
NKX2-8	-0.2
INSM1	-0.199
ZNF831	-0.188
RIPPLY2	-0.187
HCRTR2	-0.187
TRIP13	-0.186
TACR3	-0.186
CLPSL2	-0.183

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of PRDM1 mRNA"	24172598
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNA	12419474
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of PRDM1 protein	27585668
C029728	4-phenylenediamine	PRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]	27585668
C058722	5-hydroxy-6,8,11,14,17-eicosapentaenoic acid	"5-hydroxy-6,8,11,14,17-eicosapentaenoic acid affects the expression of PRDM1 mRNA"	26984781
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of PRDM1 mRNA	28959563
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of PRDM1 mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PRDM1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PRDM1 gene	27153756
C011512	alpha-naphthoflavone	"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA]"	20562217
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of PRDM1 mRNA	21298039
C015001	arsenite	arsenite results in decreased expression of PRDM1 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of PRDM1 mRNA]	18929588
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of PRDM1 mRNA"	18687144\|2416032
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PRDM1 mRNA	20064835\|2231617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PRDM1 mRNA	21569818\|2261060
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRDM1 mRNA"	20382639
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of PRDM1 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the methylation of PRDM1 promoter	27334623
C006780	bisphenol A	bisphenol A affects the expression of PRDM1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PRDM1 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PRDM1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PRDM1 mRNA	12160620
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of PRDM1 mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of PRDM1 mRNA	26272509
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRDM1 mRNA	20938992
C059262	cidofovir	cidofovir results in decreased expression of PRDM1 mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of PRDM1 mRNA	25596134
D003033	Coal Tar	Coal Tar results in increased expression of PRDM1 mRNA	27858113
C014347	decitabine	decitabine affects the expression of PRDM1 mRNA	23300844
D002945	Cisplatin	Cisplatin affects the expression of PRDM1 mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of PRDM1 mRNA	25596134
D002945	Cisplatin	Cisplatin results in increased expression of PRDM1 mRNA	21532991
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA	16931933
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA"	20562217
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PRDM1 mRNA"	20562217
D015127	9,10-Dimethyl-1,2-benzanthracene	"AHR protein affects the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA]"	20562217
D015127	9,10-Dimethyl-1,2-benzanthracene	"alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA]"	20562217
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of PRDM1 protein	27585668
D004137	Dinitrochlorobenzene	PRDM1 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of IL18 protein]	27585668
D004237	Diuron	Diuron metabolite results in increased expression of PRDM1 mRNA	24172598
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PRDM1 mRNA	23550701
C024565	ethylene dichloride	ethylene dichloride results in increased expression of PRDM1 mRNA	28189721
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRDM1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of PRDM1 mRNA	23649840
D007069	Ifosfamide	Ifosfamide results in decreased expression of PRDM1 mRNA	25596134
D019469	Indinavir	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA	16931933
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PRDM1 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of PRDM1 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRDM1 mRNA	25119042
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PRDM1 mRNA	23086925\|2479639
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PRDM1 mRNA	19237549\|1967514
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PRDM1 protein	19675145\|2034823
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] promotes the reaction [BACH2 protein binds to PRDM1 intron]	21296099
D008070	Lipopolysaccharides	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 mRNA]	19237549\|1967514
D008070	Lipopolysaccharides	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 protein]	19675145\|2034823
D018021	Lithium Chloride	Lithium Chloride results in increased expression of PRDM1 mRNA	17506889
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRDM1 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of PRDM1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of PRDM1 mRNA	26307267
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRDM1 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PRDM1 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PRDM1 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PRDM1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of PRDM1 mRNA	21613230
D009151	Mustard Gas	Mustard Gas results in increased expression of PRDM1 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PRDM1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PRDM1 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of PRDM1 mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in increased expression of PRDM1 mRNA	22714537
D010100	Oxygen	Oxygen deficiency results in increased expression of PRDM1 mRNA	25596134\|2651600
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PRDM1 mRNA	26272509
C551803	PCI 32765	PCI 32765 results in decreased expression of PRDM1 mRNA	26254443
C506614	PD 0325901	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of PRDM1 mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of PRDM1 mRNA	25119042
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PRDM1 mRNA	26272509
D010705	Phosgene	Phosgene affects the expression of PRDM1 mRNA	16300373
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of PRDM1 mRNA	22714537
D019258	Saquinavir	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA	16931933
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of PRDM1 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PRDM1 mRNA	25351596
C017947	sodium arsenite	sodium arsenite affects the methylation of PRDM1 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of PRDM1 mRNA	22714537
D018038	Sodium Selenite	Sodium Selenite results in increased expression of PRDM1 mRNA	24383545
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRDM1 mRNA	26378955
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] promotes the reaction [BACH2 protein binds to PRDM1 intron]	21296099
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of PRDM1 mRNA]	21807014
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of PRDM1 protein]	21807014
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 mRNA]	19237549\|1967514
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 protein]	19675145\|2034823
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [PRDM1 protein binds to PAX5 promoter]	19237549
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PRDM1 mRNA	21296099
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PRDM1 mRNA	25613284
D013893	Thiram	Thiram results in decreased expression of PRDM1 mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in increased expression of PRDM1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of PRDM1 gene	26864933
D014212	Tretinoin	Tretinoin results in decreased expression of PRDM1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in increased expression of PRDM1 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PRDM1 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in increased expression of PRDM1 mRNA	19140230
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRDM1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PRDM1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PRDM1 mRNA	23179753\|2438349
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of PRDM1 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PRDM1 gene	25487561
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA	16931933
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of PRDM1 mRNA	17506889
C088658	zoledronic acid	zoledronic acid results in increased expression of PRDM1 mRNA	24714768\|2559613

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IBA	21873635
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	1851123
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	1851123
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	TAS	1851123
GO:0005515	protein binding	-	IPI	22555612
GO:0008168	methyltransferase activity	-	IEA	-
GO:0031490	chromatin DNA binding	-	IBA	21873635
GO:0042826	histone deacetylase binding	-	IBA	21873635
GO:0042826	histone deacetylase binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-
GO:1990841	promoter-specific chromatin binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	1851123
GO:0001763	morphogenesis of a branching structure	-	IEA	-
GO:0001893	maternal placenta development	-	IEA	-
GO:0002250	adaptive immune response	-	IEA	-
GO:0003170	heart valve development	-	IEA	-
GO:0003281	ventricular septum development	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007281	germ cell development	-	IEA	-
GO:0009791	post-embryonic development	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IEA	-
GO:0022008	neurogenesis	-	IBA	21873635
GO:0030889	negative regulation of B cell proliferation	-	IEA	-
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	-	IEA	-
GO:0032259	methylation	-	IEA	-
GO:0032823	regulation of natural killer cell differentiation	-	ISS	-
GO:0033082	regulation of extrathymic T cell differentiation	-	ISS	-
GO:0035904	aorta development	-	IEA	-
GO:0042462	eye photoreceptor cell development	-	IEA	-
GO:0045087	innate immune response	-	IEA	-
GO:0045165	cell fate commitment	-	IBA	21873635
GO:0045165	cell fate commitment	-	IEA	-
GO:0045579	positive regulation of B cell differentiation	-	IEA	-
GO:0048844	artery morphogenesis	-	IEA	-
GO:0051136	regulation of NK T cell differentiation	-	ISS	-
GO:0060576	intestinal epithelial cell development	-	IEA	-
GO:0060707	trophoblast giant cell differentiation	-	IEA	-
GO:0060976	coronary vasculature development	-	IEA	-
GO:1990654	sebum secreting cell proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	21421998

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-6804754	Regulation of TP53 Expression	TAS
R-HSA-6806003	Regulation of TP53 Expression and Degradation	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25263394	A large candidate-gene association study suggests genetic variants at IRF5 and PRDM1 to be associated with aggressive periodontitis. (2014 Dec)	Schaefer AS	J Clin Periodontol