Gene: CDH23

64072
CDHR23|PITA5|USH1D
cadherin related 23
protein-coding
10q22.1
Ensembl:ENSG00000107736 MIM:605516 Vega:OTTHUMG00000019347 UniprotKB:Q9H251
NG_008835.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.223e-1 (AD)  4.740e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10823825chr10:71694880 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10999882chr10:71566583 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10999845chr10:71480604 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08293528chr10:73565688CDH235.170e-8Alcohol consumption der day27843151
cg17485681chr10:73565625CDH231.510e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMOD10.778
TMBIM10.735
ANO60.728
FLNA0.721
ZNF2170.713
STAT5A0.711
ITGB40.711
PLP20.71
IL13RA10.708
ECE10.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.443
ABCC12-0.443
MARCH4-0.44
PPEF1-0.426
KCNB2-0.425
ATOH7-0.423
SMIM18-0.408
GSG1-0.402
CASC15-0.401
SLC7A4-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH23 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH23 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of CDH23 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CDH23 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDH23 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CDH23 mRNA20458559
D001507BeclomethasoneBeclomethasone results in decreased expression of CDH23 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDH23 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of CDH23 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CDH23 gene28505145
D002104CadmiumCadmium results in decreased expression of CDH23 mRNA24084258
D003010ClorgylineClorgyline results in increased expression of CDH23 mRNA19691856
D003471CuprizoneCuprizone results in increased expression of CDH23 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CDH23 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDH23 mRNA21266533
D000431EthanolEthanol affects the expression of CDH23 mRNA26730594
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH23 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of CDH23 mRNA18035473
D005839GentamicinsGentamicins results in increased expression of CDH23 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDH23 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CDH23 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDH23 mRNA23103053
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CDH23 mRNA22401849
D009532NickelNickel results in decreased expression of CDH23 mRNA24084258
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDH23 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH23 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CDH23 mRNA26272509
C005556propionaldehydepropionaldehyde results in increased expression of CDH23 mRNA26079696
C059514resveratrolresveratrol results in increased expression of CDH23 mRNA25888808
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDH23 mRNA25895662
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CDH23 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDH23 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDH23 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of CDH23 gene26756918
D014212TretinoinTretinoin results in increased expression of CDH23 mRNA15977162
C012589trichostatin Atrichostatin A results in increased expression of CDH23 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDH23 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CDH23 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of CDH23 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CDH23 gene25487561

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI12485990  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IMP17234811  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007601visual perception-IEA-  
GO:0007605sensory perception of sound-IMP15537665  16679490  17234811  
GO:0007626locomotory behavior-IEA-  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-NAS11138009  
GO:0045494photoreceptor cell maintenance-IMP16679490  
GO:0050896response to stimulus-IEA-  
GO:0050953sensory perception of light stimulus-IMP16679490  
GO:0050957equilibrioception-IMP16679490  
GO:0051480regulation of cytosolic calcium ion concentration-IMP17234811  
GO:0060122inner ear receptor cell stereocilium organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-NAS11138009  
GO:0016021integral component of membrane-IEA-  
GO:0032420stereocilium-ISS12485990  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26756918Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)Zhu XEnviron Health Perspect
16598924[Association of cadherin CDH23 gene polymorphisms with noise induced hearing loss in Chinese workers]. (2006 Jan)Yang MWei Sheng Yan Jiu
19268276Genome-wide association study of smoking initiation and current smoking. (2009 Mar)Vink JMAm J Hum Genet
24448297Genetic variants of CDH23 associated with noise-induced hearing loss. (2014 Feb)Kowalski TJOtol Neurotol