Gene: WIPF3

644150
CR16
WAS/WASL interacting protein family member 3
protein-coding
7p14.3
Ensembl:ENSG00000122574 MIM:612432 Vega:OTTHUMG00000152761 UniprotKB:A6NGB9
NC_000007.14
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.262e-2 (AD)  5.851e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1108402chr7:29877002 (GRCh38.p7)C>G / C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTK2B0.928
KIAA1211L0.922
CIT0.917
CAMKK10.915
PDE1B0.913
ATP6V1H0.906
DAPK10.905
PHYHIP0.904
FBXO310.904
NCKIPSD0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.524
KLRB1-0.512
FZD10-0.491
TFPI2-0.483
SGMS2-0.478
HEY2-0.462
CTNNA3-0.455
KLRF1-0.451
TBX21-0.45
YES1-0.447

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of WIPF3 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of WIPF3 mRNA"28903501
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WIPF3 mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of WIPF3 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIPF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIPF3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of WIPF3 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WIPF3 mRNA16483693
D001151ArsenicArsenic affects the methylation of WIPF3 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of WIPF3 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of WIPF3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WIPF3 mRNA21839799
C038328BEP protocolBEP protocol results in increased expression of WIPF3 mRNA18987330
C006780bisphenol Abisphenol A results in decreased expression of WIPF3 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of WIPF3 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of WIPF3 mRNA23125180
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WIPF3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WIPF3 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of WIPF3 mRNA28962523
C118739entinostatentinostat results in increased expression of WIPF3 mRNA27188386
D017313FenretinideFenretinide results in decreased expression of WIPF3 mRNA28973697
D017313FenretinideFenretinide results in increased expression of WIPF3 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of WIPF3 mRNA26191083
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of WIPF3 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of WIPF3 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of WIPF3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WIPF3 mRNA"25554681
D009532NickelNickel results in decreased expression of WIPF3 mRNA24768652|2558310
D009966OrphenadrineOrphenadrine affects the expression of WIPF3 mRNA23665939
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of WIPF3 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of WIPF3 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIPF3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of WIPF3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of WIPF3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of WIPF3 mRNA23018184
C005556propionaldehydepropionaldehyde results in increased expression of WIPF3 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of WIPF3 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WIPF3 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of WIPF3 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to WIPF3 gene]21762485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WIPF3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WIPF3 mRNA18796159|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WIPF3 mRNA23238561
D013849ThimerosalThimerosal results in decreased expression of WIPF3 mRNA27188386
D014212TretinoinTretinoin results in increased expression of WIPF3 mRNA23830798
D014635Valproic AcidValproic Acid results in increased expression of WIPF3 mRNA19101580|2493525
C025643vinclozolinvinclozolin results in increased expression of WIPF3 mRNA20566332|2261537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0017124SH3 domain binding-IEA-  
GO:0051015actin filament binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000147actin cortical patch assembly-IBA21873635  
GO:0006897endocytosis-IBA21873635  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0008360regulation of cell shape-IBA21873635  
GO:0030048actin filament-based movement-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0051127positive regulation of actin nucleation-IBA21873635  
GO:0051666actin cortical patch localization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005884actin filament-IBA21873635  
GO:0030479actin cortical patch-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisIEA
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationTAS
R-HSA-2029482Regulation of actin dynamics for phagocytic cup formationIEA
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsTAS
R-HSA-5663213RHO GTPases Activate WASPs and WAVEsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal