Gene: TMEM168

64418
-
transmembrane protein 168
protein-coding
7q31.1
Ensembl:ENSG00000146802 Vega:OTTHUMG00000155188 UniprotKB:Q9H0V1
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.224e-2 (AD)  8.947e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7806781chr7:112780017 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UEVLD0.857
SLC35A30.843
NUP1070.836
SENP70.834
TMEM2090.833
SEPSECS0.823
GSTCD0.823
ZNF1000.821
ZNF518A0.82
ZNF430.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.458
OR4F29-0.424
EPPIN-0.335
FOXD4L1-0.285
CELSR1-0.281
NPC1L1-0.265
TLR9-0.255
UTF1-0.249
NPW-0.241
LCN1-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TMEM168 mRNA26690555
D006710HomocysteineHomocysteine results in decreased expression of TMEM168 mRNA17326132
D001151ArsenicArsenic affects the methylation of TMEM168 gene25304211
C006780bisphenol Abisphenol A results in increased expression of TMEM168 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TMEM168 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM168 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of TMEM168 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of TMEM168 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of TMEM168 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of TMEM168 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of TMEM168 mRNA20106945
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TMEM168 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM168 gene20938992
C544151jinfukangjinfukang results in decreased expression of TMEM168 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of TMEM168 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM168 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM168 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TMEM168 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TMEM168 promoter"26251327
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of TMEM168 mRNA20971185
D017239PaclitaxelTMEM168 protein affects the susceptibility to Paclitaxel16217747
D010936Plant ExtractsPlant Extracts results in increased expression of TMEM168 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of TMEM168 mRNA21632981
D012643SeleniumSelenium results in decreased expression of TMEM168 mRNA19244175
D018038Sodium SeleniteSodium Selenite results in decreased expression of TMEM168 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM168 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM168 mRNA21570461
D014635Valproic AcidValproic Acid results in decreased methylation of TMEM168 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM168 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0030133transport vesicle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal