Gene: SGCG

6445
35DAG|A4|DAGA4|DMDA|DMDA1|LGMD2C|MAM|SCARMD2|SCG3|gamma-SG
sarcoglycan gamma
protein-coding
13q12.12
Ensembl:ENSG00000102683 MIM:608896 Vega:OTTHUMG00000016563 UniprotKB:Q13326
NG_008759.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.875e-2 (AD)  5.649e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4770403chr13:23180988 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385B0.827
FLRT30.825
LMTK20.825
FMN10.824
KCNC10.813
LRRK10.813
SPATS20.812
OPN30.811
FRAS10.809
TAF4B0.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.512
MYL3-0.511
STON2-0.497
ASB4-0.497
BCL7C-0.49
MYOM1-0.49
MBNL3-0.488
LRAT-0.487
HEY2-0.486
RAB13-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SGCG mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGCG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGCG mRNA"27188386
C547126AZM551248AZM551248 results in decreased expression of SGCG mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGCG mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGCG mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SGCG mRNA19619570
D004958EstradiolEstradiol results in decreased expression of SGCG mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of SGCG mRNA28196854
C006780bisphenol Abisphenol A affects the expression of SGCG mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of SGCG mRNA18958704
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SGCG mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of SGCG mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of SGCG mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SGCG mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of SGCG mRNA25016146
D004147DioxinsDioxins affects the expression of SGCG mRNA20463971
D004397FonofosFonofos results in increased methylation of SGCG promoter22847954
C039281furanfuran results in increased expression of SGCG mRNA27387713
D017313FenretinideFenretinide results in decreased expression of SGCG mRNA28973697
D007545IsoproterenolIsoproterenol results in decreased expression of SGCG18808529
C500085muraglitazarmuraglitazar results in decreased expression of SGCG mRNA21515302
D009532NickelNickel results in decreased expression of SGCG mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SGCG mRNA27935865
D010126OzoneOzone results in decreased expression of SGCG mRNA12763052
D010278ParathionParathion results in increased methylation of SGCG promoter22847954
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SGCG mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of SGCG mRNA18301758
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of SGCG mRNA19167446
C017947sodium arsenitesodium arsenite affects the methylation of SGCG gene28589171
D053260SootSoot results in increased expression of SGCG mRNA26551751
C012568terbufosterbufos results in increased methylation of SGCG promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SGCG mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SGCG mRNA19619570
C009495titanium dioxidetitanium dioxide results in decreased expression of SGCG mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SGCG mRNA20133372
C057693troglitazonetroglitazone results in decreased expression of SGCG mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGCG mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SGCG mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SGCG mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SGCG mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10629222  23414517  
GO ID GO Term Qualifier Evidence PubMed
GO:0007517muscle organ development-TAS8641426  
GO:0060047heart contraction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-TAS8641426  
GO:0016012sarcoglycan complex-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0042383sarcolemma-IBA21873635  
KEGG ID KEGG Term
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal