Gene: NDST4

64579
N-HSST|N-HSST 4|NDST-4|NHSST4
N-deacetylase and N-sulfotransferase 4
protein-coding
4q26
Ensembl:ENSG00000138653 MIM:615039 Vega:OTTHUMG00000132916 UniprotKB:Q9H3R1
NC_000004.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.779e-1 (AD)  1.378e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13150562chr4:115036437 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLD50.562
IGF10.542
NXPH10.514
HAPLN10.512
VGLL20.508
MYO160.503
KCNA30.503
KCNMB20.502
TOX30.496
OR7A170.494

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGST1-0.318
PLIN4-0.312
STON2-0.295
ZNF296-0.292
ALDH1L1-0.292
IMPA2-0.289
NBPF10-0.287
TMPRSS3-0.282
RFX4-0.281
NTSR2-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NDST4 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of NDST4 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of NDST4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NDST4 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of NDST4 mRNA25979313
D016572CyclosporineCyclosporine results in increased expression of NDST4 mRNA20106945
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of NDST4 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NDST4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NDST4 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of NDST4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NDST4 mRNA25895662
C012589trichostatin Atrichostatin A results in increased expression of NDST4 mRNA27188386
D014635Valproic AcidValproic Acid affects the expression of NDST4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NDST4 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NDST4 gene25560391
C111237vorinostatvorinostat results in increased expression of NDST4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity-IEA-  
GO:0019213deacetylase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015012heparan sulfate proteoglycan biosynthetic process-IEA-  
GO:0030210heparin biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23953852Genome-wide association studies of maximum number of drinks. (2013 Nov)Pan YJ Psychiatr Res