Gene: TNS3

64759
TEM6|TENS1
tensin 3
protein-coding
7p12.3
Ensembl:ENSG00000136205 MIM:606825 Vega:OTTHUMG00000074075 UniprotKB:Q68CZ2
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.477e-1 (AD)  5.384e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs334524chr7:47526559 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10158598chr7:47344579TNS3Gene body2.605e-5Alcohol use disorders26763658
cg16466303chr7:47343426TNS3Gene body6.732e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMOT0.873
APCDD10.844
SELENBP10.831
ZNF4230.827
FAM167A0.826
ACBD70.825
EMID10.823
EZR0.823
MYO100.82
SFXN50.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASEF-0.427
NRG1-0.427
NPFFR2-0.417
DPP4-0.417
SSTR2-0.415
HS3ST2-0.414
FOXP2-0.413
MUM1L1-0.41
CHN2-0.403
LRRC55-0.401

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of TNS3 mRNA"19561079
D000082AcetaminophenAcetaminophen results in decreased expression of TNS3 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of TNS3 mRNA28959563
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of TNS3 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TNS3 mRNA21298039
D016718Arachidonic AcidArachidonic Acid results in decreased expression of TNS3 mRNA16704987
C015001arsenitearsenite results in increased methylation of TNS3 promoter23974009
D001241AspirinAspirin results in increased expression of TNS3 mRNA11906190
D001280AtrazineAtrazine results in decreased expression of TNS3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNS3 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNS3 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNS3 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TNS3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TNS3 mRNA19619570
D004958Estradiol[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TNS3 mRNA21185374
C044887beta-methylcholinebeta-methylcholine affects the expression of TNS3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of TNS3 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TNS3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TNS3 mRNA26079696
D002104CadmiumCadmium results in increased oxidation of TNS3 protein24077948
C018021cobaltous chloridecobaltous chloride results in decreased expression of TNS3 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of TNS3 mRNA24386269
D003300Copper[Disulfiram binds to Copper] which results in increased expression of TNS3 mRNA24690739
C030973cupric oxidecupric oxide results in decreased expression of TNS3 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of TNS3 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of TNS3 mRNA20106945|2556210
D000069439DasatinibDasatinib results in increased expression of TNS3 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TNS3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of TNS3 mRNA19561079|2160359
C000944dicrotophosdicrotophos results in increased expression of TNS3 mRNA28302478
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of TNS3 mRNA24690739
D004237DiuronDiuron results in decreased expression of TNS3 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNS3 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TNS3 mRNA23649840
C540355fenamidonefenamidone results in increased expression of TNS3 mRNA27029645
D005472FluorouracilTNS3 protein affects the susceptibility to Fluorouracil16217747
D017313FenretinideFenretinide results in decreased expression of TNS3 mRNA28973697
D017313FenretinideFenretinide results in increased expression of TNS3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TNS3 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of TNS3 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNS3 mRNA24796395|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNS3 mRNA25982114
D007649KetamineKetamine results in increased expression of TNS3 mRNA20080153
D007854LeadLead results in decreased expression of TNS3 mRNA19921347
C031895lead chromatelead chromate results in decreased expression of TNS3 mRNA23584427
C045463leflunomideleflunomide results in increased expression of TNS3 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNS3 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the methylation of TNS3 promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNS3 mRNA"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TNS3 mRNA22401849
C523799MRK 003TNS3 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNS3 mRNA"25554681
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNS3 mRNA"12756304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TNS3 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNS3 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TNS3 protein26879310
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of TNS3 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNS3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TNS3 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of TNS3 mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TNS3 mRNA27029645
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA19059307
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TNS3 mRNA21185374
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNS3 mRNA25351596
D012834SilverSilver results in increased expression of TNS3 mRNA27131904
C016104sodium bichromatesodium bichromate results in decreased expression of TNS3 mRNA17685462
D018038Sodium SeleniteSodium Selenite results in decreased expression of TNS3 mRNA23274088
D013467SulindacSulindac results in decreased expression of TNS3 mRNA11906190
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA19059307
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of TNS3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNS3 mRNA19619570|2010694
D019284ThapsigarginThapsigargin results in decreased expression of TNS3 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TNS3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TNS3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TNS3 mRNA17431108|2193413
C034613triacsin Ctriacsin C results in decreased expression of TNS3 mRNA16704987
C012589trichostatin Atrichostatin A affects the expression of TNS3 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of TNS3 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TNS3 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TNS3 mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of TNS3 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of TNS3 mRNA28001369|2915479
C025643vinclozolinvinclozolin results in decreased expression of TNS3 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of TNS3 mRNA22570695
D019287Zinc SulfateZinc Sulfate results in increased expression of TNS3 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16273093  17190795  19732724  24658140  24728074  
GO ID GO Term Qualifier Evidence PubMed
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0016477cell migration-IEA-  
GO:0048286lung alveolus development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8875513MET interacts with TNS proteinsTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal