Gene: CCDC14

64770
-
coiled-coil domain containing 14
protein-coding
3q21.1
Ensembl:ENSG00000175455 MIM:617147 Vega:OTTHUMG00000153005 UniprotKB:Q49A88
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.454e-1 (AD)  6.288e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4678073chr3:123948677 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC140.917
BIVM0.905
DOPEY10.904
CCNT20.902
MFN10.901
CCPG10.895
TCERG10.895
WDR110.893
ZNF780B0.891
REV10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.412
S100A1-0.401
OR4F29-0.376
AQP5-0.342
LRAT-0.336
RAB13-0.335
BCL7C-0.332
S100A14-0.33
MDFI-0.329
RBP1-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CCDC14 mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of CCDC14 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CCDC14 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC14 gene27153756
D001280AtrazineAtrazine results in decreased expression of CCDC14 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of CCDC14 mRNA22323515
C044887beta-methylcholinebeta-methylcholine affects the expression of CCDC14 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of CCDC14 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of CCDC14 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of CCDC14 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of CCDC14 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CCDC14 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CCDC14 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CCDC14 mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of CCDC14 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of CCDC14 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CCDC14 mRNA21592394
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CCDC14 mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CCDC14 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC14 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CCDC14 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCDC14 mRNA23649840
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CCDC14 mRNA27153767
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CCDC14 mRNA19167446
D010042OuabainOuabain results in decreased expression of CCDC14 mRNA16412265
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CCDC14 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CCDC14 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CCDC14 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC14 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCDC14 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCDC14 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCDC14 mRNA28065790
D014635Valproic AcidValproic Acid results in decreased expression of CCDC14 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of CCDC14 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CCDC14 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17043677  25416956  26297806  26496610  26638075  
GO ID GO Term Qualifier Evidence PubMed
GO:0021762substantia nigra development-HEP22926577  
GO:0071539protein localization to centrosome-IMP26297806  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IDA21399614  
GO:0034451centriolar satellite-IDA26297806  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal