Gene: ST3GAL1

6482
Gal-NAc6S|SIAT4A|SIATFL|ST3GalA|ST3GalA.1|ST3GalIA|ST3GalIA,1|ST3O
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
protein-coding
8q24.22
Ensembl:ENSG00000008513 MIM:607187 Vega:OTTHUMG00000164534 UniprotKB:Q11201
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.713e-1 (AD)  7.627e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6989475chr8:133507022 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12140977chr8:134513309ST3GAL14.400e-8Smoking27651444
cg00026474chr8:134585500ST3GAL18.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FURIN0.838
KDM5C0.829
KDM2A0.824
SMG70.822
ZDHHC50.822
PLXNA20.819
SIK20.819
BAHD10.816
ATXN2L0.815
TSPAN140.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.518
OR4F29-0.477
KLRC2-0.366
PDE11A-0.35
SH2D1A-0.314
C5orf64-0.314
IAPP-0.313
CTNNA3-0.309
SOX14-0.295
TRDN-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ST3GAL1 mRNA"28903501
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ST3GAL1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ST3GAL1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ST3GAL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST3GAL1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST3GAL1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ST3GAL1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ST3GAL1 mRNA24449571
D001151ArsenicArsenic affects the methylation of ST3GAL1 gene25304211
D001554BenzeneBenzene results in increased expression of ST3GAL1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST3GAL1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST3GAL1 mRNA21802500
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ST3GAL1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST3GAL1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST3GAL1 mRNA22228805|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ST3GAL1 mRNA"20382639
D004958EstradiolEstradiol affects the expression of ST3GAL1 mRNA14699072|2257421
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of ST3GAL1 mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ST3GAL1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ST3GAL1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ST3GAL1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ST3GAL1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of ST3GAL1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ST3GAL1 mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of ST3GAL1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ST3GAL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ST3GAL1 gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ST3GAL1 mRNA22079614
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
D020122tert-Butylhydroperoxidepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
C018475butyraldehydebutyraldehyde results in increased expression of ST3GAL1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ST3GAL1 mRNA21457566
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ST3GAL1 mRNA17484886
D002330CarmustineST3GAL1 mRNA affects the susceptibility to Carmustine16365179
D002994ClofibrateClofibrate results in decreased expression of ST3GAL1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ST3GAL1 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ST3GAL1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL1 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of ST3GAL1 mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ST3GAL1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ST3GAL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ST3GAL1 mRNA27594783
D004026DieldrinDieldrin results in increased expression of ST3GAL1 mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of ST3GAL1 mRNA18042831
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ST3GAL1 mRNA23649840
C039281furanfuran results in decreased expression of ST3GAL1 mRNA25539665
C071834glycidamideglycidamide results in decreased expression of ST3GAL1 mRNA17822822
D017313FenretinideFenretinide results in increased expression of ST3GAL1 mRNA15958647
D017313FenretinideFenretinide results in decreased expression of ST3GAL1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of ST3GAL1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ST3GAL1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ST3GAL1 mRNA23086925
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA22839698
D008095Lithocholic AcidLithocholic Acid analog results in decreased expression of and results in decreased activity of ST3GAL1 protein21224350
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ST3GAL1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ST3GAL1 mRNA26378955
D008694MethamphetamineMethamphetamine results in increased expression of ST3GAL1 mRNA26307267
D008727MethotrexateMethotrexate results in decreased expression of ST3GAL1 mRNA24449571
D008727MethotrexateMethotrexate affects the expression of ST3GAL1 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST3GAL1 mRNA23649840
C523799MRK 003ST3GAL1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ST3GAL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ST3GAL1 mRNA"25554681
D009532NickelNickel results in increased expression of ST3GAL1 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in decreased expression of ST3GAL1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ST3GAL1 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of ST3GAL1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of ST3GAL1 mRNA23892564
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ST3GAL1 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of ST3GAL1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of ST3GAL1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST3GAL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ST3GAL1 mRNA26272509
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
C060836pioglitazonepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
C006253pirinixic acidpirinixic acid results in decreased expression of ST3GAL1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of ST3GAL1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ST3GAL1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ST3GAL1 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ST3GAL1 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of ST3GAL1 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of ST3GAL1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of ST3GAL1 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA19059307
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ST3GAL1 mRNA19167446
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ST3GAL1 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of ST3GAL1 mRNA18175754
C056684soyasaponin Isoyasaponin I results in decreased activity of ST3GAL1 protein11394903
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ST3GAL1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ST3GAL1 mRNA26378955
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA19059307
C047246temozolomideST3GAL1 mRNA affects the susceptibility to temozolomide16365179
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ST3GAL1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST3GAL1 mRNA19619570|2180250
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST3GAL1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL1 mRNA19770486|2892240
D013752TetracyclineTetracycline results in increased expression of ST3GAL1 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST3GAL1 mRNA25613284
D014212TretinoinTretinoin results in increased expression of ST3GAL1 mRNA21934132|2383079
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of ST3GAL1 mRNA26898711
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ST3GAL1 mRNA"26179874
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ST3GAL1 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ST3GAL1 mRNA]20847119
D014635Valproic AcidValproic Acid affects the expression of ST3GAL1 mRNA17963808
C029297vinylidene chloridevinylidene chloride results in increased expression of ST3GAL1 mRNA26682919
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IDA14722111  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-ISS-  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006054N-acetylneuraminate metabolic process-ISS-  
GO:0006464cellular protein modification process-TAS10504389  
GO:0006487protein N-linked glycosylation-ISS-  
GO:0016266O-glycan processing-TAS-  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0097503sialylation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa00512Mucin type O-Glycan biosynthesis
hsa00533Glycosaminoglycan biosynthesis - keratan sulfate
hsa00603Glycosphingolipid biosynthesis - globo series
hsa00604Glycosphingolipid biosynthesis - ganglio series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27704662Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. (2016 Dec)Nio-Kobayashi JMol Reprod Dev