Gene: ST3GAL3

6487
EIEE15|MRT12|SIAT6|ST3GALII|ST3Gal III|ST3GalIII|ST3N
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
protein-coding
1p34.1
Ensembl:ENSG00000126091 MIM:606494 Vega:OTTHUMG00000007561 UniprotKB:Q11203
NG_028196.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.394e-1 (AD)  9.799e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12760274chr1:43783673 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRSN20.958
BSCL20.949
KATNB10.948
STOML10.947
ACTR1B0.946
CDK50.945
NDRG40.944
FAM131A0.944
LRRC200.944
CRMP10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.616
OR4F29-0.56
RAI14-0.523
CNN2-0.519
TFPI2-0.508
CLEC2B-0.506
REST-0.506
WWTR1-0.5
CST7-0.486
KCNJ15-0.483

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ST3GAL3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST3GAL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST3GAL3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ST3GAL3 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ST3GAL3 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ST3GAL3 mRNA16483693
D001151ArsenicArsenic affects the methylation of ST3GAL3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST3GAL3 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST3GAL3 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of ST3GAL3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ST3GAL3 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of ST3GAL3 mRNA26191083
C054133casticincasticin results in decreased expression of ST3GAL3 mRNA28444820
D016572CyclosporineCyclosporine results in decreased expression of ST3GAL3 mRNA19770486
D002945CisplatinCisplatin results in decreased expression of ST3GAL3 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ST3GAL3 mRNA21607683
D004147DioxinsDioxins affects the expression of ST3GAL3 mRNA20463971
D004317DoxorubicinDoxorubicin results in decreased expression of ST3GAL3 mRNA19277126
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ST3GAL3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ST3GAL3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of ST3GAL3 mRNA28189721
C033789fenarimolfenarimol results in increased expression of ST3GAL3 mRNA28970091
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA21607683
C069837fullerene C60fullerene C60 results in increased expression of ST3GAL3 mRNA19167457
C039281furanfuran results in increased methylation of ST3GAL3 gene22079235
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ST3GAL3 protein18951874
C031927hydroquinonehydroquinone results in decreased expression of ST3GAL3 mRNA23776099
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of ST3GAL3 mRNA23776099
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of ST3GAL3 mRNA19376150
C492448ICG 001ICG 001 results in increased expression of ST3GAL3 mRNA26191083
D008095Lithocholic AcidLithocholic Acid analog results in decreased activity of ST3GAL3 protein21224350
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ST3GAL3 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of ST3GAL3 mRNA29191790
D009532NickelNickel results in decreased expression of ST3GAL3 mRNA25583101
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ST3GAL3 mRNA21334430
C045950propiconazolepropiconazole results in decreased expression of ST3GAL3 mRNA21278054
C045950propiconazolepropiconazole results in increased expression of ST3GAL3 mRNA28970091
C005556propionaldehydepropionaldehyde results in decreased expression of ST3GAL3 mRNA26079696
C059514resveratrolresveratrol results in increased expression of ST3GAL3 mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ST3GAL3 mRNA25895662
D012999SomanSoman results in decreased expression of ST3GAL3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST3GAL3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ST3GAL3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ST3GAL3 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST3GAL3 mRNA17942748
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ST3GAL3 protein18951874
D013853ThioacetamideThioacetamide results in decreased expression of ST3GAL3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of ST3GAL3 mRNA18052213
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ST3GAL3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ST3GAL3 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of ST3GAL3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ST3GAL3 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-IBA21873635  
GO:0003836beta-galactoside (CMP) alpha-2,3-sialyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016266O-glycan processing-TAS-  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
KEGG ID KEGG Term
hsa00514Other types of O-glycan biosynthesis
hsa00533Glycosaminoglycan biosynthesis - keratan sulfate
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638074Keratan sulfate/keratin metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1912420Pre-NOTCH Processing in GolgiIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-2022854Keratan sulfate biosynthesisTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3656243Defective ST3GAL3 causes MCT12 and EIEE15TAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27704662Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. (2016 Dec)Nio-Kobayashi JMol Reprod Dev