Gene: SLC1A1

6505
DCBXA|EAAC1|EAAT3|SCZD18
solute carrier family 1 member 1
protein-coding
9p24.2
Ensembl:ENSG00000106688 MIM:133550 Vega:OTTHUMG00000019468 UniprotKB:P43005
NG_017044.1
PubMed|SNP Mapped
3   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.591e-1 (AD)  6.181e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12682807chr9:4574022 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17812250chr9:4517894 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10814995chr9:4505544 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEATR5B0.889
PAM0.889
MEF2A0.885
ENTPD40.881
LGALSL0.879
G3BP20.876
POLR2B0.876
SEC23A0.874
RNF1450.874
SACM1L0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.481
OR4F29-0.46
HEY2-0.396
EYA2-0.392
LRAT-0.384
S100A1-0.382
GPR143-0.377
ACOX2-0.37
EVC2-0.36
CYP11A1-0.359

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00230PregabalinSmall Molecule148553-50-8Approved|Illicit|InvestigationalTransporter
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of SLC1A1 mRNA"24680724
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]16150575
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of SLC1A1 protein23602688|2435558
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
D000111AcetylcysteineAcetylcysteine affects the reaction [SLC1A1 protein affects the transport of Zinc]22575539
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of SLC1A1 protein]"18093171
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the metabolism of SLC1A1 protein]"18093171
C016601afimoxifeneafimoxifene results in decreased expression of SLC1A1 mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC1A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC1A1 mRNA22100608
D000596Amino AcidsAmino Acids results in increased expression of SLC1A1 mRNA26338884
D000596Amino AcidsAmino Acids results in increased expression of SLC1A1 protein26338884
D000641AmmoniaAmmonia results in decreased expression of SLC1A1 protein26318273
D000641AmmoniaAmmonia results in increased expression of SLC1A1 protein26318273
D000641Ammoniaresveratrol inhibits the reaction [Ammonia results in decreased expression of SLC1A1 protein]26318273
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC1A1 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC1A1 mRNA24449571
D016589AstemizoleAstemizole results in increased expression of SLC1A1 mRNA20221588
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC1A1 mRNA22316170
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of SLC1A1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC1A1 mRNA21569818|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC1A1 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC1A1 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SLC1A1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC1A1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SLC1A1 mRNA18191855|1961957
C006780bisphenol Abisphenol A results in decreased expression of SLC1A1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of SLC1A1 mRNA21980460
C006780bisphenol Abisphenol A affects the expression of SLC1A1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SLC1A1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
C006780bisphenol Abisphenol A results in increased methylation of SLC1A1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SLC1A1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased activity of SLC1A1 protein17382927
D020122tert-Butylhydroperoxide[Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]17382927
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A1 mRNA20360939
D002110CaffeineCaffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]23262392
D002110CaffeineCaffeine results in decreased activity of SLC1A1 protein23262392
C058819calphostin Ccalphostin C inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
C058819calphostin Ccalphostin C results in decreased activity of SLC1A1 protein24355585
D002220CarbamazepineCarbamazepine affects the expression of SLC1A1 mRNA25979313
D002220Carbamazepine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]16150575
D002220CarbamazepineCarbamazepine results in increased activity of SLC1A1 protein16150575
D002220Carbamazepinewortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]16150575
C016299chelerythrinechelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
C016299chelerythrinechelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
C016299chelerythrinechelerythrine results in decreased activity of SLC1A1 protein17382927|2326239
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of SLC1A1 protein22627295
D002737ChloropreneChloroprene results in decreased expression of SLC1A1 mRNA23125180
D004390Chlorpyrifos[Chlorpyrifos co-treated with NGF protein] results in increased expression of SLC1A1 mRNA20600679
D003024ClozapineClozapine results in decreased expression of SLC1A1 mRNA12873733
D060729Coal AshCoal Ash results in decreased expression of SLC1A1 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC1A1 mRNA19376846
D003513CycloheximideCycloheximide inhibits the reaction [Tretinoin results in increased expression of SLC1A1 mRNA]19450544
D016572CyclosporineCyclosporine results in decreased expression of SLC1A1 mRNA20106945|2798913
C438269diazepinylbenzoic aciddiazepinylbenzoic acid inhibits the reaction [Tretinoin results in increased activity of SLC1A1 protein]19450544
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of SLC1A1 mRNA21791302
D002945CisplatinSLC1A1 mRNA affects the susceptibility to Cisplatin18610736
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A1 mRNA20360939
D002117CalcitriolCalcitriol results in increased expression of SLC1A1 mRNA16002434
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of SLC1A1 mRNA28939011
C061132diphenyldiselenidediphenyldiselenide results in increased expression of SLC1A1 protein19926633
C118739entinostatentinostat results in increased expression of SLC1A1 mRNA27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC1A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A1 mRNA17942748
D018683Excitatory Amino Acid AgentsSLC1A1 protein results in increased transport of Excitatory Amino Acid Agents21688266
D004397FonofosFonofos results in increased methylation of SLC1A1 promoter22847954
D006220HaloperidolHaloperidol results in decreased expression of SLC1A1 mRNA12873733
D017313FenretinideFenretinide results in decreased expression of SLC1A1 mRNA28973697
C422175HX 630HX 630 promotes the reaction [tamibarotene results in increased activity of SLC1A1 protein]19450544
C422175HX 630HX 630 promotes the reaction [tamibarotene results in increased expression of SLC1A1 protein]19450544
D007051Ibotenic AcidIbotenic Acid results in decreased expression of SLC1A1 mRNA12183397
D007052IbuprofenIbuprofen results in increased expression of SLC1A1 mRNA28201806
D007608Kainic AcidKainic Acid results in decreased expression of SLC1A1 mRNA17997037
D007657Ketone BodiesKetone Bodies results in increased expression of SLC1A1 mRNA16807920
C104183LE 540LE 540 inhibits the reaction [Tretinoin results in increased activity of SLC1A1 protein]19450544
D007854LeadLead results in increased expression of SLC1A1 protein15149801
C008261lead acetatelead acetate results in increased expression of SLC1A1 mRNA15985313
C008261lead acetatelead acetate results in increased expression of SLC1A1 protein15985313
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC1A1 mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC1A1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC1A1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC1A1 mRNA"26251327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of SLC1A1 protein"18093171
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the metabolism of SLC1A1 protein"18093171
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of SLC1A1 protein]"18093171
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the metabolism of SLC1A1 protein]"18093171
D016685MitomycinSLC1A1 protein affects the susceptibility to Mitomycin16217747
D009151Mustard GasMustard Gas results in increased expression of SLC1A1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC1A1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SLC1A1 mRNA12832660
D009538NicotineNicotine results in decreased activity of SLC1A1 protein24355585
D009538NicotineTetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]24355585
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of SLC1A1 mRNA25607892
D017239PaclitaxelPaclitaxel results in decreased expression of SLC1A1 protein16361064
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of SLC1A1 mRNA21791302
D010278ParathionParathion results in increased methylation of SLC1A1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SLC1A1 mRNA26705709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC1A1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC1A1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC1A1 mRNA26272509
D010862PilocarpinePilocarpine results in increased expression of SLC1A1 mRNA11906504
D010862PilocarpinePilocarpine results in increased expression of SLC1A1 protein11906504
C006253pirinixic acidpirinixic acid results in decreased expression of SLC1A1 mRNA17426115
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SLC1A1 mRNA22714537
D000069583Pregabalinchelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
D000069583PregabalinPregabalin results in increased activity of SLC1A1 protein22511482
D000069583PregabalinStaurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
D000069583Pregabalinwortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
D011280PregnanolonePregnanolone results in increased localization of and results in increased activity of SLC1A1 protein21688266
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC1A1 mRNA19162173
C024273profenofosprofenofos results in decreased expression of SLC1A1 mRNA17569032
D011374ProgesteroneProgesterone results in increased expression of SLC1A1 mRNA23012394|2301818
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SLC1A1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of SLC1A1 mRNA21540246
D011374Progesterone2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D011374Progesteronecalphostin C inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D011374Progesteronechelerythrine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D011374ProgesteroneProgesterone results in increased activity of SLC1A1 protein23602688
D011374ProgesteroneStaurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D011374Progesteronewortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D015742Propofol[Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]17382927
C059514resveratrolresveratrol inhibits the reaction [Ammonia results in decreased expression of SLC1A1 protein]26318273
D012402RotenoneRotenone results in decreased expression of SLC1A1 mRNA23186747
D012402RotenoneRotenone results in increased expression of SLC1A1 mRNA19013527
D012643SeleniumSelenium results in decreased expression of SLC1A1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC1A1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of SLC1A129204679
D019311StaurosporineStaurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
D019311StaurosporineStaurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
D019311StaurosporineStaurosporine results in decreased activity of SLC1A1 protein17382927|2326239
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of SLC1A1 mRNA16214533
C061133tamibaroteneHX 630 promotes the reaction [tamibarotene results in increased activity of SLC1A1 protein]19450544
C061133tamibaroteneHX 630 promotes the reaction [tamibarotene results in increased expression of SLC1A1 protein]19450544
C061133tamibarotenetamibarotene results in increased activity of SLC1A1 protein19450544
C061133tamibarotenetamibarotene results in increased expression of SLC1A1 protein19450544
C012568terbufosterbufos results in increased methylation of SLC1A1 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC1A1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC1A1 mRNA19901195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC1A1 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A1 mRNA17942748
D013755Tetradecanoylphorbol AcetateCaffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]23262392
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]17382927
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]24355585
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein17382927|2326239
D013793ThalliumThallium binds to and results in increased activity of SLC1A1 protein18986164
D013849ThimerosalThimerosal results in increased expression of SLC1A1 protein15184908
C009495titanium dioxidetitanium dioxide results in increased expression of SLC1A1 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of SLC1A1 mRNA21934132
D014212TretinoinCycloheximide inhibits the reaction [Tretinoin results in increased expression of SLC1A1 mRNA]19450544
D014212Tretinoindiazepinylbenzoic acid inhibits the reaction [Tretinoin results in increased activity of SLC1A1 protein]19450544
D014212TretinoinLE 540 inhibits the reaction [Tretinoin results in increased activity of SLC1A1 protein]19450544
D014212TretinoinRARB mutant form inhibits the reaction [Tretinoin results in increased expression of SLC1A1 mRNA alternative form]19450544
D014212TretinoinTretinoin results in increased activity of SLC1A1 protein19450544
D014212TretinoinTretinoin results in increased expression of SLC1A1 mRNA alternative form19450544
D014212TretinoinTretinoin results in increased expression of SLC1A1 protein19450544
C012589trichostatin Atrichostatin A results in increased expression of SLC1A1 mRNA24935251|2670570
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of SLC1A1 mRNA17982090
D014415TunicamycinTunicamycin results in decreased expression of SLC1A1 mRNA22378314
C022884undecaneundecane results in decreased expression of SLC1A1 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC1A1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC1A1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC1A1 mRNA19101580|2317975
D014639VanadiumVanadium results in decreased expression of SLC1A1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC1A1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC1A1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of SLC1A1 mRNA20044591
C111237vorinostatvorinostat results in increased expression of SLC1A1 mRNA18769122
C070417Win 55212-2Win 55212-2 results in increased expression of SLC1A1 protein17631920
C009687wortmanninwortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]16150575
C009687wortmanninwortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]22511482
C009687wortmanninwortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]23602688
C009687wortmanninwortmannin results in decreased activity of SLC1A1 protein23262392|2360268
D015215ZidovudineZidovudine results in increased expression of SLC1A1 mRNA24292225
D015032ZincAcetylcysteine affects the reaction [SLC1A1 protein affects the transport of Zinc]22575539
D015032ZincSLC1A1 protein affects the transport of Zinc22575539
C022189zonisamidezonisamide results in increased expression of SLC1A1 protein12941455

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005313L-glutamate transmembrane transporter activity-IDA7521911  21123949  
GO:0005314high-affinity glutamate transmembrane transporter activity-IDA8857541  26690923  
GO:0005314high-affinity glutamate transmembrane transporter activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0015108chloride transmembrane transporter activity-IMP8857541  
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015501glutamate:sodium symporter activity-IDA8857541  
GO:0016595glutamate binding-IEA-  
GO:0033229cysteine transmembrane transporter activity-IDA21123949  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0007268chemical synaptic transmission-TAS7521911  
GO:0010460positive regulation of heart rate-IEA-  
GO:0014047glutamate secretion-TAS-  
GO:0015813L-glutamate transmembrane transport-IDA21123949  26690923  
GO:0042883cysteine transport-IDA21123949  
GO:0051260protein homooligomerization-IEA-  
GO:0051938L-glutamate import-IDA7521911  
GO:0070779D-aspartate import across plasma membrane-IDA7521911  
GO:0070779D-aspartate import across plasma membrane-IMP8857541  
GO:0098712L-glutamate import across plasma membrane-IDA26690923  
GO:0098712L-glutamate import across plasma membrane-IMP8857541  
GO:0140009L-aspartate import across plasma membrane-IMP8857541  
GO:1902476chloride transmembrane transport-IMP8857541  
GO:1903712cysteine transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA21123949  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IMP8857541  26690923  
GO:0016020membrane-TAS7521911  
GO:0016324apical plasma membrane-IDA21123949  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619067Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
25743187Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. (2015 Mar 2)Pickering CPharmacol Biochem Behav
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol