Gene: TMEM135

65084
PMP52
transmembrane protein 135
protein-coding
11q14.2
Ensembl:ENSG00000166575 MIM:616360 Vega:OTTHUMG00000167248 UniprotKB:Q86UB9
NC_000011.10
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.202e-2 (AD)  1.083e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17149800chr11:87184579 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4944672chr11:87178406 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1948206chr11:87178242 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs17149719chr11:87084891 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C6orf1200.863
FBXO30.856
SC5D0.852
TMEM106B0.852
NUP1330.852
GTF2A10.851
CLCN30.85
PEX30.849
RCN20.849
HLTF0.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.475
CSAG1-0.387
MTRNR2L6-0.373
MTRNR2L9-0.361
PPBP-0.351
MTRNR2L2-0.349
MTRNR2L10-0.344
MTRNR2L8-0.33
FOLR3-0.327

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TMEM135 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of TMEM135 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TMEM135 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TMEM135 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMEM135 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TMEM135 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TMEM135 mRNA24449571
D001151ArsenicArsenic affects the methylation of TMEM135 gene25304211
C547126AZM551248AZM551248 results in decreased expression of TMEM135 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM135 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM135 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of TMEM135 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TMEM135 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of TMEM135 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TMEM135 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TMEM135 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of TMEM135 mRNA25979313
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TMEM135 mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of TMEM135 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TMEM135 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of TMEM135 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TMEM135 mRNA]27941970
C016366dibenzothiophenedibenzothiophene results in decreased expression of TMEM135 mRNA23656968
C000944dicrotophosdicrotophos results in decreased expression of TMEM135 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TMEM135 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMEM135 mRNA17555576
D017313FenretinideFenretinide results in decreased expression of TMEM135 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of TMEM135 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of TMEM135 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of TMEM135 mRNA27392435
C410337K 7174K 7174 results in decreased expression of TMEM135 mRNA24086573
C045463leflunomideleflunomide results in increased expression of TMEM135 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM135 mRNA23179753|2718838
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMEM135 mRNA"25620056
D017239PaclitaxelTMEM135 protein affects the susceptibility to Paclitaxel16217747
D010416PentachlorophenolPentachlorophenol results in increased expression of TMEM135 mRNA24642059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMEM135 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TMEM135 mRNA17426115|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TMEM135 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TMEM135 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of TMEM135 mRNA21632981
C059514resveratrolresveratrol results in increased expression of TMEM135 protein25505154
D012715Sesame OilSesame Oil results in increased expression of TMEM135 mRNA29191790
D013629TamoxifenTamoxifen affects the expression of TMEM135 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM135 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM135 mRNA15328365|1977048
C406224valdecoxibvaldecoxib results in increased expression of TMEM135 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TMEM135 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM135 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of TMEM135 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM135 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TMEM135 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007031peroxisome organization-ISS-  
GO:0009409response to cold-IEA-  
GO:0032094response to food-IEA-  
GO:0090140regulation of mitochondrial fission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005777peroxisome-ISS-  
GO:0005778peroxisomal membrane-IEA-  
GO:0005811lipid droplet-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031966mitochondrial membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal