Gene: SLC6A11

6538
GAT-3|GAT3|GAT4
solute carrier family 6 member 11
protein-coding
3p25.3
Ensembl:ENSG00000132164 MIM:607952 Vega:OTTHUMG00000129718 UniprotKB:P48066
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.206e-2 (AD)  2.835e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3774084chr3:10916591 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14788003chr3:10916026SLC6A116.700e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A30.893
ATP1B20.886
SOX90.88
NTRK20.874
SLC39A120.87
ZNRF30.87
FGFR30.869
MLC10.868
PBXIP10.868
PRDM160.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCARA5-0.43
GADL1-0.429
CETP-0.415
TDRD1-0.403
FER1L6-0.398
TNFRSF19-0.392
OR4F5-0.382
NOX4-0.376
CD244-0.373
CCDC68-0.37

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00349ClobazamSmall Molecule22316-47-8Approved|IllicitTransporter
DB08848GuvacineSmall Molecule498-96-4ExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC6A11 mRNA"25614096
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A11 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SLC6A11 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC6A11 mRNA21298039
D005680gamma-Aminobutyric AcidSLC6A11 results in increased export of gamma-Aminobutyric Acid21748804
D005680gamma-Aminobutyric AcidFlufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D005680gamma-Aminobutyric AcidNiflumic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D005680gamma-Aminobutyric AcidSLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid15981712
D005680gamma-Aminobutyric AcidSLC6A11 protein results in increased uptake of [gamma-Aminobutyric Acid co-treated with Sodium co-treated with Chlorides]15981712
D005680gamma-Aminobutyric AcidSodium promotes the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D005680gamma-Aminobutyric AcidSLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid28621878
D005680gamma-Aminobutyric AcidWasp Venoms inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]28621878
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC6A11 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A11 mRNA26001963
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SLC6A11 mRNA18692832
C006780bisphenol Abisphenol A results in increased expression of SLC6A11 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of SLC6A11 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SLC6A11 mRNA25181051
D002712ChloridesSLC6A11 protein binds to and results in increased uptake of Chlorides15981712
D002712ChloridesSLC6A11 protein results in increased uptake of Chlorides15981712
D002712ChloridesSLC6A11 protein results in increased uptake of [gamma-Aminobutyric Acid co-treated with Sodium co-treated with Chlorides]15981712
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC6A11 mRNA17553155
D003975DiazepamDiazepam results in increased expression of SLC6A11 mRNA15802192
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC6A11 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC6A11 mRNA20360939
D005439Flufenamic AcidFlufenamic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SLC6A11 mRNA12539871
D007854LeadLead affects the expression of SLC6A11 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of SLC6A11 mRNA22613225
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC6A11 mRNA21219332
D009544Niflumic AcidNiflumic Acid inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D010126OzoneOzone results in decreased expression of SLC6A11 mRNA16330353
D010269ParaquatParaquat results in increased expression of SLC6A11 mRNA21371552
C033457phenobarbital quinidinephenobarbital quinidine results in increased expression of SLC6A11 mRNA15802192
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC6A11 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SLC6A11 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of SLC6A11 mRNA21219332
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC6A11 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLC6A11 mRNA23608068
C045362prochlorazprochloraz results in increased expression of SLC6A11 mRNA21470553
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SLC6A11 mRNA18692832
D011374ProgesteroneProgesterone results in decreased expression of SLC6A11 mRNA18692832
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC6A11 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SLC6A11 mRNA21632981
D012964SodiumSLC6A11 protein binds to and results in increased uptake of Sodium15981712
D012964SodiumSLC6A11 protein results in increased uptake of [gamma-Aminobutyric Acid co-treated with Sodium co-treated with Chlorides]15981712
D012964SodiumSodium promotes the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]15981712
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC6A11 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC6A11 mRNA24680724
C012589trichostatin Atrichostatin A results in decreased expression of SLC6A11 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of SLC6A11 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of SLC6A11 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC6A11 gene25560391
D014862Wasp VenomsWasp Venoms inhibits the reaction [SLC6A11 protein results in increased uptake of gamma-Aminobutyric Acid]28621878
D015215ZidovudineZidovudine results in increased expression of SLC6A11 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0005332gamma-aminobutyric acid:sodium symporter activity-IBA21873635  
GO:0005332gamma-aminobutyric acid:sodium symporter activity-TAS-  
GO:0042165neurotransmitter binding-IBA21873635  
GO:0042165neurotransmitter binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007420brain development-IEA-  
GO:0015812gamma-aminobutyric acid transport-IEA-  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS1400419  
GO:0042995cell projection-IEA-  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS
R-HSA-71288Creatine metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS
R-HSA-888593Reuptake of GABATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res