Gene: SLC8A3

6547
NCX3
solute carrier family 8 member A3
protein-coding
14q24.2
Ensembl:ENSG00000100678 MIM:607991 Vega:OTTHUMG00000152342 UniprotKB:P57103
NG_047080.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.639e-1 (AD)  8.496e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4902778chr14:70113519 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1035717chr14:70111982 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR610.922
DCLK10.915
TMEM1690.909
NUAK10.908
MARK10.908
STXBP5L0.907
PLCL20.904
REEP10.903
GPR1580.903
NRXN30.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.611
AGTRAP-0.603
ROM1-0.594
TMEM176A-0.59
FXYD3-0.585
TGIF1-0.578
RHOD-0.577
HVCN1-0.575
NUPR1-0.574
VAMP5-0.563

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]17585341
C1016702-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate results in decreased activity of SLC8A3 protein20888801
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC8A3 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A3 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SLC8A3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC8A3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC8A3 mRNA21298039
D000638AmiodaroneAmiodarone results in decreased activity of SLC8A3 protein15288574
D001280AtrazineAtrazine results in decreased expression of SLC8A3 mRNA25929836
C006780bisphenol Abisphenol A results in increased expression of SLC8A3 mRNA23146750
C006780bisphenol Abisphenol A results in decreased expression of SLC8A3 mRNA25181051
D002118CalciumSLC8A3 protein results in increased transport of Calcium17585341
D002118CalciumSLC8A3 protein results in increased uptake of Calcium14660663
D002994ClofibrateClofibrate results in decreased expression of SLC8A3 mRNA22300585
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC8A3 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of SLC8A3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SLC8A3 mRNA18042831
D000431EthanolEthanol results in increased expression of SLC8A3 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of SLC8A3 mRNA]"20655511
C540355fenamidonefenamidone results in decreased expression of SLC8A3 mRNA27029645
D004397FonofosFonofos results in increased methylation of SLC8A3 promoter22847954
D007608Kainic Acid2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]17585341
D007608Kainic AcidKainic Acid results in increased cleavage of SLC8A3 protein17585341
D007854LeadLead affects the expression of SLC8A3 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC8A3 mRNA23103053
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of SLC8A3 mRNA]"20655511
D010100OxygenOxygen deficiency results in increased expression of SLC8A3 mRNA26516004
D000073878Palm OilPalm Oil results in decreased expression of SLC8A3 mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of SLC8A3 mRNA18042831
D010278ParathionParathion results in increased methylation of SLC8A3 promoter22847954
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC8A3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SLC8A3 mRNA23806026
C012568terbufosterbufos results in increased methylation of SLC8A3 promoter22847954
D014212TretinoinTretinoin results in increased expression of SLC8A3 mRNA21934132
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC8A3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC8A3 mRNA24383497|2627250
D014635Valproic AcidValproic Acid affects the expression of SLC8A3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC8A3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005432calcium:sodium antiporter activity-ISS-  
GO:0005432calcium:sodium antiporter activity-TAS-  
GO:0005516calmodulin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0099580ion antiporter activity involved in regulation of postsynaptic membrane potential-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0006811ion transport-TAS-  
GO:0006851mitochondrial calcium ion transmembrane transport-ISS-  
GO:0006874cellular calcium ion homeostasis-ISS-  
GO:0007154cell communication-IEA-  
GO:0007612learning-ISS-  
GO:0007613memory-ISS-  
GO:0014819regulation of skeletal muscle contraction-ISS-  
GO:0021537telencephalon development-IEA-  
GO:0035725sodium ion transmembrane transport-ISS-  
GO:0042552myelination-ISS-  
GO:0048709oligodendrocyte differentiation-ISS-  
GO:0051560mitochondrial calcium ion homeostasis-ISS-  
GO:0060078regulation of postsynaptic membrane potential-IEA-  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0070588calcium ion transmembrane transport-ISS-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071456cellular response to hypoxia-ISS-  
GO:0098703calcium ion import across plasma membrane-IEA-  
GO:1903779regulation of cardiac conduction-TAS-  
GO:1990034calcium ion export across plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-ISS-  
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0016528sarcoplasm-IEA-  
GO:0030054cell junction-IEA-  
GO:0031226intrinsic component of plasma membrane-IDA21959935  
GO:0031594neuromuscular junction-ISS-  
GO:0042383sarcolemma-ISS-  
GO:0043197dendritic spine-IEA-  
GO:0043204perikaryon-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA21959935  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382551Transport of small moleculesIEA
R-HSA-397014Muscle contractionTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418359Reduction of cytosolic Ca++ levelsTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425561Sodium/Calcium exchangersTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-8949215Mitochondrial calcium ion transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal