Gene: SLC9A2

6549
NHE2
solute carrier family 9 member A2
protein-coding
2q12.1
Ensembl:ENSG00000115616 MIM:600530 Vega:OTTHUMG00000130778 UniprotKB:Q9UBY0
NG_050930.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.315e-1 (AD)  3.045e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6726894chr2:102680477 (GRCh38.p7)C>A / C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MFSD90.698
TBC1D40.671
NPNT0.649
SLC16A140.647
PLCB40.645
KLF80.642
PKP20.636
ACTA2-AS10.636
PTPRM0.633
TPM10.629

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.379
NKX2-2-0.361
DPF3-0.355
HMX1-0.339
IZUMO4-0.335
RIBC1-0.324
FAM181A-0.323
NRN1L-0.318
KIAA1755-0.318
LHPP-0.315

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC9A2 mRNA"19114083
C0741073-methylsulfonyl-4-piperidinobenzoyl guanidine3-methylsulfonyl-4-piperidinobenzoyl guanidine results in decreased activity of SLC9A2 protein11159350|1170456
D000584Amiloride[Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides10958346
D000584Amiloride[Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium10958346
D000641Ammonia[Ammonia co-treated with Hydrocortisone] results in increased expression of SLC9A2 mRNA19252005
D000641AmmoniaAmmonia inhibits the reaction [SLC9A2 protein results in increased uptake of Sodium]10958346
D000643Ammonium Chloride[Ammonium Chloride co-treated with Hydrocortisone] results in increased expression of SLC9A2 mRNA19252005
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC9A2 mRNA16483693
D004958EstradiolEstradiol results in increased expression of SLC9A2 mRNA23019147
D004958EstradiolEstradiol results in decreased expression of SLC9A2 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SLC9A2 mRNA26496021
D004958EstradiolEstradiol results in increased expression of SLC9A2 mRNA23509787
D004958EstradiolEstradiol results in increased expression of SLC9A2 protein23509787
D001639BicarbonatesSLC9A2 protein affects the transport of Bicarbonates11704563
C006780bisphenol Abisphenol A results in decreased expression of SLC9A2 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SLC9A2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC9A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC9A2 gene28505145
C093373cariporide[cariporide results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides10958346
C093373cariporide[cariporide results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium10958346
D002712Chlorides[Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides10958346
D002712Chlorides[cariporide results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides10958346
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SLC9A2 mRNA18636392
D003042CocaineCocaine results in decreased expression of SLC9A2 mRNA18000554
D003471CuprizoneCuprizone results in decreased expression of SLC9A2 mRNA26577399
D003634DDT"[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA"27325568
C014347decitabine[decitabine co-treated with CDX2 protein] results in increased expression of SLC9A2 mRNA18845559
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SLC9A2 mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC9A2 mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SLC9A2 protein23301498
D005419FlavonoidsFlavonoids results in increased expression of SLC9A2 mRNA18035473
C039281furanfuran results in decreased methylation of SLC9A2 gene27387713
C039281furanfuran results in increased expression of SLC9A2 mRNA27387713
D006854Hydrocortisone[Ammonia co-treated with Hydrocortisone] results in increased expression of SLC9A2 mRNA19252005
D006854Hydrocortisone[Ammonium Chloride co-treated with Hydrocortisone] results in increased expression of SLC9A2 mRNA19252005
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SLC9A2 mRNA26846883
D007477Ions[Water co-treated with Ions deficiency] results in increased expression of SLC9A2 mRNA17299134
D015122MercaptopurineMercaptopurine results in decreased expression of SLC9A2 mRNA23358152
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC9A2 mRNA26924002
C028007nickel monoxidenickel monoxide results in decreased expression of SLC9A2 mRNA19167457
C016340o,p'-DDT"[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA"27325568
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SLC9A2 mRNA18636392
D011374ProgesteroneProgesterone results in decreased expression of SLC9A2 mRNA21770760
D011522ProtonsSLC9A2 protein affects the transport of Protons17943310
D012964Sodium[Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium10958346
D012964SodiumAmmonia inhibits the reaction [SLC9A2 protein results in increased uptake of Sodium]10958346
D012964Sodium[cariporide results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium10958346
D012964SodiumSLC9A2 protein results in increased uptake of Sodium10958346
D012999SomanSoman results in decreased expression of SLC9A2 mRNA19281266
D043343Testosterone PropionateTestosterone Propionate results in increased expression of SLC9A2 mRNA15601916
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC9A2 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC9A2 mRNA23557971|2776080
D014635Valproic AcidValproic Acid results in increased methylation of SLC9A2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC9A2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC9A2 mRNA26682919
D014867Water[Water co-treated with Ions deficiency] results in increased expression of SLC9A2 mRNA17299134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015385sodium:proton antiporter activity-IBA21873635  
GO:0015385sodium:proton antiporter activity-TAS-  
GO:0015386potassium:proton antiporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0008104protein localization-IEA-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0098719sodium ion import across plasma membrane-IBA21873635  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425986Sodium/Proton exchangersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal