Gene: TMEM108

66000
CT124|RTLN
transmembrane protein 108
protein-coding
3q22.1
Ensembl:ENSG00000144868 MIM:617361 Vega:OTTHUMG00000159685 UniprotKB:Q6UXF1
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.071e-2 (AD)  9.374e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10935045chr3:133081302 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLRT20.877
SRGAP30.858
ASTN10.856
ZBTB180.856
GRAMD1B0.855
NRXN10.853
LRRC40.853
RNF440.849
FHOD30.847
HS6ST10.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.516
SGMS2-0.492
OR4F5-0.467
SH2D1A-0.467
PPBP-0.456
RAI14-0.45
CTNNA3-0.45
WWTR1-0.449
SPINK8-0.447
CCR2-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TMEM108 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TMEM108 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of TMEM108 mRNA17562736
D000447AldehydesAldehydes results in increased expression of TMEM108 mRNA25014914
D000638AmiodaroneAmiodarone affects the expression of TMEM108 mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TMEM108 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of TMEM108 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of TMEM108 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TMEM108 promoter]19654925
C006780bisphenol Abisphenol A results in increased expression of TMEM108 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TMEM108 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TMEM108 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of TMEM108 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of TMEM108 mRNA25064622
D004041Dietary FatsDietary Fats results in increased expression of TMEM108 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMEM108 mRNA25064622
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM108 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TMEM108 mRNA26011545
D010269ParaquatParaquat affects the expression of TMEM108 mRNA25064622
C410127PCB 180PCB 180 results in increased expression of TMEM108 mRNA23829299
C046012pentanalpentanal results in increased expression of TMEM108 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM108 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TMEM108 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of TMEM108 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of TMEM108 mRNA26079696
D013629TamoxifenTamoxifen results in decreased expression of TMEM108 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TMEM108 mRNA19770486
D013752TetracyclineTetracycline affects the expression of TMEM108 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of TMEM108 mRNA25064622
D014212TretinoinTretinoin results in decreased expression of TMEM108 mRNA23724009
D014415TunicamycinTunicamycin results in decreased expression of TMEM108 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of TMEM108 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of TMEM108 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of TMEM108 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TMEM108 mRNA23179753|2519280
D014635Valproic AcidValproic Acid affects the expression of TMEM108 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0008090retrograde axonal transport-ISS-  
GO:0008150biological_process-ND-  
GO:0021542dentate gyrus development-ISS-  
GO:0031175neuron projection development-ISS-  
GO:0051388positive regulation of neurotrophin TRK receptor signaling pathway-ISS-  
GO:0097106postsynaptic density organization-ISS-  
GO:0097484dendrite extension-ISS-  
GO:0098815modulation of excitatory postsynaptic potential-ISS-  
GO:1990416cellular response to brain-derived neurotrophic factor stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005769early endosome-ISS-  
GO:0010008endosome membrane-ISS-  
GO:0014069postsynaptic density-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-IEA-  
GO:0036477somatodendritic compartment-ISS-  
GO:0045211postsynaptic membrane-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (2011 Sep 15)Heath ACBiol Psychiatry