Gene: TRAK2

66008
ALS2CR3|CALS-C|GRIF-1|GRIF1|MILT2|OIP98
trafficking kinesin protein 2
protein-coding
2q33.1
Ensembl:ENSG00000115993 MIM:607334 Vega:OTTHUMG00000132822 UniprotKB:O60296
NC_000002.12
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.017e-1 (AD)  7.925e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1558637chr2:201398651 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2244438chr2:201387816 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10202963chr2:201377184 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNC1LI20.897
PKP40.883
ZNF3260.878
ZEB20.862
PTP4A20.853
PTPN110.842
ZNF6640.837
WNK10.836
ANKRD400.83
GAB20.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.514
OR4F5-0.424
RNF43-0.295
RGR-0.288
C6orf223-0.265
TMPRSS3-0.263
HES7-0.241
SLC13A5-0.241
GOLGA6L1-0.228
MATN4-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of TRAK2 mRNA"22101062
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRAK2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TRAK2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TRAK2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TRAK2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TRAK2 mRNA17562736
C016601afimoxifeneafimoxifene results in decreased expression of TRAK2 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRAK2 gene27153756
D000452AldrinAldrin results in decreased expression of TRAK2 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRAK2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TRAK2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of TRAK2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAK2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAK2 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TRAK2 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of TRAK2 mRNA16514628
C006780bisphenol Abisphenol A results in increased expression of TRAK2 mRNA25181051
D002737ChloropreneChloroprene results in increased expression of TRAK2 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TRAK2 mRNA18668222
C018021cobaltous chloridecobaltous chloride results in increased expression of TRAK2 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of TRAK2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAK2 mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAK2 mRNA18579281
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TRAK2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TRAK2 mRNA27392435
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TRAK2 mRNA25380136
C070081fulvestrantfulvestrant results in decreased expression of TRAK2 mRNA16514628
D005839GentamicinsGentamicins results in decreased expression of TRAK2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TRAK2 mRNA16671099
D007213IndomethacinIndomethacin results in decreased expression of TRAK2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAK2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TRAK2 mRNA27392435
D007854LeadLead affects the splicing of TRAK2 mRNA28903495
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA16415329
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRAK2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRAK2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TRAK2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TRAK2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TRAK2 mRNA25380136
C025589ochratoxin Aochratoxin A results in decreased acetylation of TRAK2 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of TRAK2 promoter] which results in decreased expression of TRAK2 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of TRAK2 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TRAK2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TRAK2 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TRAK2 mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TRAK2 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRAK2 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TRAK2 mRNA16514628
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA16415329
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TRAK2 mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAK2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of TRAK2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRAK2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAK2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRAK2 mRNA25613284
D014050TolueneToluene results in decreased expression of TRAK2 mRNA22166486
D014050TolueneToluene results in increased expression of TRAK2 mRNA22166486
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TRAK2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TRAK2 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TRAK2 mRNA"26743178
D014501UraniumUranium affects the expression of TRAK2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TRAK2 mRNA15672453
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRAK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TRAK2 mRNA19101580|2317975
C025643vinclozolinvinclozolin affects the expression of TRAK2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of TRAK2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-ISS12034717  
GO:0005515protein binding-IPI15644324  
GO:0017022myosin binding-IBA21873635  
GO:0019894kinesin binding-IEA-  
GO:0019899enzyme binding-IEA-  
GO:0030911TPR domain binding-IEA-  
GO:0050811GABA receptor binding-IBA21873635  
GO:0050811GABA receptor binding-NAS15644324  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006493protein O-linked glycosylation-IEA-  
GO:0006605protein targeting-IBA21873635  
GO:0006605protein targeting-IEA-  
GO:0008089anterograde axonal transport-IBA21873635  
GO:0008104protein localization-IBA21873635  
GO:0008333endosome to lysosome transport-IEA-  
GO:0022008neurogenesis-IBA21873635  
GO:0047496vesicle transport along microtubule-IBA21873635  
GO:0048311mitochondrion distribution-IBA21873635  
GO:0048813dendrite morphogenesis-IEA-  
GO:0050771negative regulation of axonogenesis-IEA-  
GO:0098957anterograde axonal transport of mitochondrion-IBA21873635  
GO:0098972anterograde dendritic transport of mitochondrion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS12034717  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS-  
GO:0005769early endosome-IEA-  
GO:0005886plasma membrane-ISS12034717  
GO:0030425dendrite-IBA21873635  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0032839dendrite cytoplasm-IBA21873635  
GO:0032839dendrite cytoplasm-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0044295axonal growth cone-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28542283Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China. (2017)Zhao XKPLoS One