Gene: SVIL

6840
-
supervillin
protein-coding
10p11.23
Ensembl:ENSG00000197321 MIM:604126 Vega:OTTHUMG00000017882 UniprotKB:O95425
NG_033998.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.141e-2 (AD)  2.132e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7079620chr10:29583020 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10261325chr10:29874759SVILPromoter7.246e-4Alcohol use disorders26763658
cg14001239chr10:29771743SVIL6.440e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMC10.842
SHE0.833
DSP0.829
MYOF0.826
TGFBR20.823
FBLIM10.82
RNF144B0.816
JAG10.815
FOXC10.815
FGD50.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.439
CHST8-0.401
HAGHL-0.4
C19orf73-0.4
FBLL1-0.4
TMEM121-0.392
TMEM179-0.388
SPEF1-0.384
MYADML2-0.383
SAC3D1-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SVIL mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SVIL mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SVIL mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SVIL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SVIL mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SVIL mRNA22230336|2906747
D020106AcrylamideAcrylamide affects the expression of SVIL mRNA28959563
C016601afimoxifeneafimoxifene results in decreased expression of SVIL mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SVIL gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SVIL mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of SVIL mRNA19774075
D001151ArsenicArsenic affects the methylation of SVIL gene25304211
C015001arsenitearsenite results in increased methylation of SVIL promoter23974009
D001280AtrazineAtrazine results in increased expression of SVIL mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of SVIL mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SVIL mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SVIL mRNA"19150397
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of SVIL mRNA]24758408
D004958EstradiolEstradiol affects the expression of SVIL mRNA25321415
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SVIL mRNA20660070
D004958EstradiolEstradiol results in increased expression of SVIL mRNA24758408|2686566
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SVIL mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SVIL mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SVIL mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of SVIL mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SVIL mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SVIL mRNA20147733
C018475butyraldehydebutyraldehyde results in decreased expression of SVIL mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of SVIL20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SVIL gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of SVIL mRNA18353800
D002996ClomipheneClomiphene results in decreased expression of SVIL mRNA26865669
C018021cobaltous chloridecobaltous chloride results in decreased expression of SVIL mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of SVIL mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of SVIL mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of SVIL mRNA18579281
D016572CyclosporineCyclosporine results in increased expression of SVIL mRNA20106945|2556210
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of SVIL mRNA17330099
D004041Dietary FatsDietary Fats results in decreased expression of SVIL mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SVIL mRNA26865669
D004147DioxinsDioxins affects the expression of SVIL mRNA20463971
D004237DiuronDiuron results in decreased expression of SVIL mRNA21551480
C118739entinostatentinostat results in increased expression of SVIL mRNA27188386
D004970EstroneEstrone results in increased expression of SVIL mRNA26865669
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of SVIL mRNA17347304
D008656MestranolMestranol results in increased expression of SVIL mRNA26865669
C540355fenamidonefenamidone results in increased expression of SVIL mRNA27029645
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of SVIL mRNA17347304
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of SVIL20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SVIL gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of SVIL mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of SVIL mRNA26865669
D019833GenisteinGenistein results in increased expression of SVIL mRNA26865669
D005839GentamicinsGentamicins results in increased expression of SVIL mRNA22061828
D006589HexestrolHexestrol results in increased expression of SVIL mRNA26865669
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SVIL mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SVIL mRNA23086925
C410337K 7174K 7174 results in increased expression of SVIL mRNA24086573
D008694MethamphetamineMethamphetamine results in increased expression of SVIL mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of SVIL20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SVIL gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SVIL mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of SVIL mRNA18548127
D015735MifepristoneMifepristone results in increased expression of SVIL mRNA17584828
C523799MRK 003MRK 003 results in decreased expression of SVIL mRNA21169257
D009151Mustard GasMustard Gas affects the expression of SVIL mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SVIL mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SVIL mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SVIL mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of SVIL mRNA24136188
C012655nimesulidenimesulide results in decreased expression of SVIL mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SVIL mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SVIL mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SVIL mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SVIL mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SVIL mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SVIL mRNA18445702|2081375
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SVIL mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SVIL mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SVIL mRNA20660070
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SVIL mRNA27029645
C009277sodium arsenatesodium arsenate results in increased expression of SVIL mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of SVIL protein28918527
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA"18579281
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of SVIL mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SVIL mRNA19901195
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SVIL mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SVIL mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SVIL mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SVIL mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SVIL mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SVIL mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SVIL mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SVIL mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of SVIL mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of SVIL mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SVIL mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SVIL mRNA29024780
C057693troglitazonetroglitazone results in increased expression of SVIL mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of SVIL mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SVIL mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SVIL mRNA19101580|2493525
C025643vinclozolinvinclozolin affects the expression of SVIL mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of SVIL mRNA23555832
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of SVIL mRNA17330099
C088658zoledronic acidzoledronic acid results in increased expression of SVIL mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18639526  
GO:0051015actin filament binding-IDA12711699  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0007519skeletal muscle tissue development-IMP12711699  
GO:0032467positive regulation of cytokinesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002102podosome-IEA-  
GO:0005634nucleus-IDA12711699  
GO:0005737cytoplasm-IDA12711699  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA12711699  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IDA-  
GO:0015629actin cytoskeleton-NAS9867483  
GO:0030496midbody-ISS-  
GO:0032154cleavage furrow-ISS-  
GO:0036449microtubule minus-end-ISS-  
GO:0043034costamere-IDA12711699  
GO:0071437invadopodium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal