Gene info: ID 6906

SNP ID	Position	Alleles	Trait	Variation Type
rs17332369	chrX:106034774 (GRCh38.p7)	T>A	alcohol dependence	SNV(Single Nucleotide Variation)

Gene Symbol	Pearson Correlation Coefficient
SPO11	0.712
IGFL3	0.674
PLA2G2E	0.672
CRYBA4	0.637
TMEM95	0.629
MUC17	0.62
GCM1	0.614
DAZL	0.604
CA6	0.59
TRIM42	0.589

Gene Symbol	Pearson Correlation Coefficient
GPR17	-0.259
CHAD	-0.239
MYBPC1	-0.219
SMOC1	-0.214
OMD	-0.214
COL20A1	-0.212
RFTN2	-0.209
RAB41	-0.206
OTC	-0.206
PDGFRA	-0.205

DrugBank
CTD

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB00279	Liothyronine	Small Molecule	6893-02-3	Approved	Carrier
DB00451	Levothyroxine	Small Molecule	51-48-9	Approved	Carrier
DB01583	Liotrix	Small Molecule	8065-29-0	Approved	Carrier
DB05235	NRP409	Small Molecule	-	Investigational	Carrier

ID	Drug Name	Action	PubMed
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of SERPINA7 mRNA"	17070881
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SERPINA7 mRNA"	28903501
C035314	1-nitropropane	1-nitropropane results in decreased expression of SERPINA7 mRNA	17070881
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SERPINA7 protein"	19750101
C555859	2,2',4,4',5,6'-hexabromodiphenyl ether	"2,2',4,4',5,6'-hexabromodiphenyl ether analog binds to SERPINA7 protein"	20804816
C500336	2,2',4,4',5-pentachlorobiphenyl	"2,2',4,4',5-pentachlorobiphenyl results in decreased expression of SERPINA7 protein"	19750101
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog binds to SERPINA7 protein"	20804816
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SERPINA7 mRNA"	20056577
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of SERPINA7 mRNA"	21920950
C067940	2,3,3',4,4'-pentachlorobiphenyl	"2,3,3',4,4'-pentachlorobiphenyl results in decreased expression of SERPINA7 protein"	19750101
C070055	2,3',4,4',5-pentachlorobiphenyl	"2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SERPINA7 protein"	19750101
C541132	2,4,4',5-tetrachlorobiphenyl	"2,4,4',5-tetrachlorobiphenyl results in decreased expression of SERPINA7 protein"	19750101
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SERPINA7 mRNA"	16984957
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of SERPINA7 mRNA"	17070881
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SERPINA7 mRNA"	21346803
C025235	2,6-diaminotoluene	"2,6-diaminotoluene results in decreased expression of SERPINA7 mRNA"	17070881
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of SERPINA7 mRNA"	21346803
C561157	2'-hydroxy-2,3',4,5'-tetrabromodipheyl ether	"2'-hydroxy-2,3',4,5'-tetrabromodipheyl ether binds to SERPINA7 protein"	20804816
C014706	2-nitro-4-phenylenediamine	2-nitro-4-phenylenediamine results in increased expression of SERPINA7 mRNA	17070881
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of SERPINA7 mRNA	14600272
C016617	2-nitropropane	2-nitropropane results in increased expression of SERPINA7 mRNA	17070881
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SERPINA7 mRNA"	16984957
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SERPINA7 mRNA"	20959002
C085794	3,5-dibromo-2-(2,4-dibromophenoxy)phenol	"3,5-dibromo-2-(2,4-dibromophenoxy)phenol analog binds to SERPINA7 protein"	20804816
C029904	3,5-dichlorobiphenyl	"3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]"	16478101
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of SERPINA7 mRNA"	25380136
C028676	4-acetylaminofluorene	4-acetylaminofluorene results in decreased expression of SERPINA7 mRNA	17070881
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of SERPINA7 mRNA	14600272
D000082	Acetaminophen	Acetaminophen results in decreased expression of SERPINA7 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SERPINA7 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SERPINA7 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SERPINA7 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SERPINA7 mRNA	14600272
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of SERPINA7 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SERPINA7 mRNA	16483693
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA	19737545
D001379	Azathioprine	Azathioprine results in decreased expression of SERPINA7 mRNA	22623647
C487081	belinostat	belinostat results in decreased expression of SERPINA7 mRNA	27188386
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of SERPINA7 mRNA	19737606
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SERPINA7 mRNA]	22234961
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of SERPINA7 mRNA	19737545
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of SERPINA7 mRNA	22234961
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of SERPINA7 mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SERPINA7 mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINA7 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SERPINA7 mRNA	21715664
D004958	Estradiol	Estradiol results in decreased expression of SERPINA7 mRNA	20106945
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in decreased expression of SERPINA7 protein	19750101
C006780	bisphenol A	bisphenol A binds to SERPINA7 protein	21517007
C006780	bisphenol A	bisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
C006780	bisphenol A	bisphenol A results in increased expression of SERPINA7 mRNA	27104808
C006780	bisphenol A	bisphenol A results in decreased expression of SERPINA7 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SERPINA7 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SERPINA7 mRNA	27339419
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SERPINA7 mRNA	18178546
D002922	Ciguatoxins	Ciguatoxins affects the expression of SERPINA7 mRNA	18353800
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SERPINA7 mRNA	17602206
D003300	Copper	SERPINA7 protein binds to Copper	23896426
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SERPINA7 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of SERPINA7 mRNA	20106945\|2163298
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of SERPINA7 mRNA]	21149847
C558403	dibromodiphenyl ether	dibromodiphenyl ether analog binds to SERPINA7 protein	20804816
D003993	Dibutyl Phthalate	[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein	29385629
D003993	Dibutyl Phthalate	pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein]	29385629
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of SERPINA7 mRNA	28962523
C000944	dicrotophos	dicrotophos results in decreased expression of SERPINA7 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of SERPINA7 mRNA	25016146
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of SERPINA7 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SERPINA7 mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SERPINA7 mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of SERPINA7 mRNA	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of SERPINA7 mRNA	14600272\|2538013
C118739	entinostat	entinostat results in decreased expression of SERPINA7 mRNA	27188386
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of SERPINA7 mRNA	24412560
D000431	Ethanol	Ethanol results in decreased expression of SERPINA7 mRNA	19167417
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SERPINA7 protein	16982228
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA	17070881
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of SERPINA7 mRNA]	15016801
D005485	Flutamide	Flutamide results in decreased expression of SERPINA7 mRNA	24136188\|2479361
D005620	Freund's Adjuvant	Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of SERPINA7 mRNA]	21149847
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of SERPINA7 mRNA	21149847
C039281	furan	furan results in increased expression of SERPINA7 mRNA	24183702
D006581	Hexachlorobenzene	Hexachlorobenzene results in decreased expression of SERPINA7 protein	19750101
D007455	Iodine	[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein	29385629
D007455	Iodine	pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein]	29385629
D007545	Isoproterenol	Isoproterenol results in increased expression of SERPINA7 mRNA	21335049
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPINA7 mRNA	26378955
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SERPINA7 protein	22265609
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of SERPINA7 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SERPINA7 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of SERPINA7 mRNA	25380136
D009532	Nickel	SERPINA7 protein binds to Nickel	23896426
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of SERPINA7 mRNA	19716841
C017576	norgestimate	[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SERPINA7 protein	16982228
D009966	Orphenadrine	Orphenadrine affects the expression of SERPINA7 mRNA	23665939
C511292	Ortho Evra	Ortho Evra results in increased expression of SERPINA7 protein	16982228
D010098	Oxycodone	Oxycodone results in decreased expression of SERPINA7 mRNA	23439660
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog binds to SERPINA7 protein	20804816
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of SERPINA7 protein	19750101
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SERPINA7 protein	19750101
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SERPINA7 mRNA	16221955
D010634	Phenobarbital	Phenobarbital affects the expression of SERPINA7 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in decreased expression of SERPINA7 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of SERPINA7 mRNA	19162173
C006253	pirinixic acid	pirinixic acid results in increased expression of SERPINA7 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of SERPINA7 mRNA	19162173
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls metabolite results in decreased expression of SERPINA7 protein	19750101
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SERPINA7 mRNA	19162173
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of SERPINA7 protein]	29385629
C031280	pyrazole	pyrazole results in increased expression of SERPINA7 mRNA	17945193
D011794	Quercetin	Quercetin results in decreased expression of SERPINA7 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in increased expression of SERPINA7 mRNA	21632981
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of SERPINA7 mRNA	25905778
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SERPINA7 mRNA	23221170
D012834	Silver	Silver results in increased expression of SERPINA7 mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in increased expression of SERPINA7 mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in increased expression of SERPINA7 mRNA	25993096
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of SERPINA7 mRNA	25905778
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPINA7 mRNA	26378955
D014284	Triiodothyronine	Triiodothyronine binds to SERPINA7 protein	20804816\|2151700
D013629	Tamoxifen	Tamoxifen results in increased expression of SERPINA7 protein	3207604
D013629	Tamoxifen	Tamoxifen results in increased expression of SERPINA7 mRNA	25123088
C020806	tetrabromobisphenol A	tetrabromobisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
C041181	tetrachlorodian	tetrachlorodian inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINA7 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SERPINA7 mRNA]	16984957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SERPINA7 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SERPINA7 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINA7 mRNA	16984957\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINA7 mRNA	18178546\|2095900
D013974	Thyroxine	"3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]"	16478101
D013974	Thyroxine	bisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
D013974	Thyroxine	tetrabromobisphenol A inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
D013974	Thyroxine	tetrachlorodian inhibits the reaction [Thyroxine binds to SERPINA7 protein]	16478101
D013974	Thyroxine	Thyroxine binds to SERPINA7 protein	16478101\|2080481
C533760	tribromodiphenyl ether 28	tribromodiphenyl ether 28 analog binds to SERPINA7 protein	20804816
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SERPINA7 mRNA	25549359
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of SERPINA7 mRNA	29024780
D014520	Urethane	Urethane results in decreased expression of SERPINA7 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of SERPINA7 mRNA	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of SERPINA7 mRNA	17292431\|1796380
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SERPINA7 gene	25560391

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004867	serine-type endopeptidase inhibitor activity	-	IBA	21873635
GO:0004867	serine-type endopeptidase inhibitor activity	-	TAS	3094014

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0070327	thyroid hormone transport	-	IMP	19415532

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005615	extracellular space	-	IBA	21873635
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

Gene: SERPINA7

ANCO-SNPs

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)