Gene: TBX15

6913
TBX14
T-box 15
protein-coding
1p12
Ensembl:ENSG00000092607 MIM:604127 Vega:OTTHUMG00000012263 UniprotKB:Q96SF7
NG_013361.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.826e-2 (AD)  6.540e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10923714chr1:118970290 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TES0.815
FBLIM10.814
S1PR30.809
FOXC10.805
SVIL0.804
CALD10.789
RBPMS0.786
ITGA10.783
CASP40.781
DSP0.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.584
HAS1-0.564
DLK2-0.562
LRTM2-0.559
SLC1A6-0.55
MYADML2-0.55
BCL11A-0.549
MARCH4-0.546
SLC7A4-0.544
TMEM179-0.543

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of TBX15 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TBX15 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TBX15 mRNA21641981
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TBX15 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TBX15 mRNA24449571
C015001arsenitearsenite results in increased methylation of TBX15 promoter23974009
C006780bisphenol Abisphenol A affects the methylation of TBX15 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TBX15 mRNA25181051
D016572CyclosporineCyclosporine results in decreased expression of TBX15 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TBX15 mRNA24317228
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TBX15 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TBX15 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TBX15 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of TBX15 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of TBX15 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TBX15 mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TBX15 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TBX15 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TBX15 mRNA23649840
D009532NickelNickel results in decreased expression of TBX15 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TBX15 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBX15 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TBX15 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of TBX15 mRNA18042831
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TBX15 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TBX15 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of TBX15 protein23718831
D053260SootSoot results in increased expression of TBX15 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TBX15 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TBX15 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBX15 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX15 mRNA22298810
D013893ThiramThiram results in increased expression of TBX15 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TBX15 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of TBX15 mRNA18230668
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TBX15 gene27618143
D014520UrethaneUrethane results in decreased expression of TBX15 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TBX15 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TBX15 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of TBX15 mRNA24896083
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBX15 mRNA"27188386
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBX15 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003714transcription corepressor activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070722Tle3-Aes complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29796116Genome-wide analysis of DNA methylation in bronchial washings. (2018)Um SWClin Epigenetics