Gene: TBXAS1

6916
BDPLT14|CYP5|CYP5A1|GHOSAL|THAS|TS|TXAS|TXS
thromboxane A synthase 1
protein-coding
7q34
Ensembl:ENSG00000059377 MIM:274180 Vega:OTTHUMG00000157302 UniprotKB:P24557
NG_008422.2
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.576e-2 (AD)  8.719e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4725563chr7:139954457 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs6958644chr7:139796416 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.959
ADAM280.944
NCKAP1L0.933
PTPRC0.932
CD370.924
IL180.921
CLEC7A0.921
APBB1IP0.918
MILR10.918
MYO1F0.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.442
MAGIX-0.426
KCNIP3-0.425
NEUROD6-0.424
RTN4R-0.417
ST6GAL2-0.415
CHRNA4-0.412
ATOH7-0.411
HAS1-0.41
KCNB2-0.407

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00795SulfasalazineSmall Molecule599-79-1ApprovedTarget
DB01207RidogrelSmall Molecule110140-89-1ApprovedTarget
DB03052DazoxibenSmall MoleculeExperimentalTarget
DB05505NM-702Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C00803312-hydroxy-5,8,10-heptadecatrienoic acid"[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid"2572437
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of TBXAS1 mRNA28522335
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of TBXAS1 protein26194647
D000082AcetaminophenAcetaminophen affects the expression of TBXAS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TBXAS1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TBXAS1 mRNA16483693
D001194AsbestosAsbestos results in increased expression of TBXAS1 mRNA22398240
D001241AspirinTBXAS1 polymorphism affects the susceptibility to Aspirin21449675
D001280AtrazineAtrazine results in increased expression of TBXAS1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of TBXAS1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TBXAS1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBXAS1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of TBXAS1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of TBXAS1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TBXAS1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TBXAS1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TBXAS1 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TBXAS1 mRNA17484886
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein12500202
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TBXAS1 protein12629582
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of TBXAS1 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBXAS1 mRNA20938992
C059262cidofovircidofovir results in increased expression of TBXAS1 mRNA25596134
D004002Clodronic AcidClodronic Acid affects the expression of TBXAS1 mRNA25596134
D019327Copper SulfateCopper Sulfate results in increased expression of TBXAS1 mRNA19549813
C067513CV 6504CV 6504 results in decreased activity of TBXAS11847762
D016572CyclosporineCyclosporine results in decreased expression of TBXAS1 mRNA25596134
C029166dazoxibendazoxiben results in decreased activity of TBXAS1 protein2704033
D002945CisplatinCisplatin results in decreased expression of TBXAS1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of TBXAS1 mRNA25596134
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TBXAS1 mRNA18544905
D002117CalcitriolCalcitriol results in increased expression of TBXAS1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TBXAS1 mRNA21592394
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of TBXAS1 mRNA19118595
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBXAS1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TBXAS1 mRNA17557909
C000499ferric oxideferric oxide analog results in increased expression of TBXAS1 mRNA24525745
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBXAS1 mRNA20938992
C039936furegrelatefuregrelate results in decreased activity of TBXAS1 protein17562850
C546771gardiquimodgardiquimod results in decreased expression of TBXAS1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of TBXAS1 mRNA]28003376
C004312glycidolglycidol results in increased expression of TBXAS1 mRNA24915197
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TBXAS1 protein18951874
D007069IfosfamideIfosfamide results in increased expression of TBXAS1 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBXAS1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of TBXAS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TBXAS1 mRNA23086925
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TBXAS1 mRNA18544905
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TBXAS1 mRNA22235868
D008070Lipopolysaccharides[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA21669866
D008070Lipopolysaccharides[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein21669866
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of TBXAS1 mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TBXAS1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TBXAS1 mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of TBXAS1 mRNA20843944
D008627Mercuric ChlorideMercuric Chloride affects the expression of TBXAS1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TBXAS1 mRNA20938992
D008729Methoxamine[Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein12500202
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of TBXAS1 mRNA17475336
C008493methylselenic acidmethylselenic acid results in decreased expression of TBXAS1 mRNA21669866
C523799MRK 003TBXAS1 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of TBXAS1 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TBXAS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TBXAS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TBXAS1 mRNA"25554681|2710602
C028007nickel monoxidenickel monoxide results in increased expression of TBXAS1 mRNA19167457
D010100OxygenOxygen deficiency results in decreased expression of TBXAS1 mRNA25596134|2651600
C002669parthenolide[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA21669866
C002669parthenolide[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein21669866
D044262Prostaglandin H2TBXAS1 protein results in increased metabolism of Prostaglandin H218264100
D010634Phenobarbital[Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein12500202
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TBXAS1 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TBXAS1 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TBXAS1 mRNA19162173
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of TBXAS1 mRNA]28003376
D011758PyrrolesPyrroles results in decreased activity of TBXAS1 protein2704033
D015363QuinolonesQuinolones analog results in decreased activity of TBXAS1 protein1311763
C060219ridogrelridogrel results in decreased activity of TBXAS1 protein2790215
D012643Selenium[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA21669866
D012643Selenium[Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein21669866
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TBXAS1 mRNA25895662
D019821SimvastatinSimvastatin results in decreased expression of TBXAS1 mRNA16414398
D019821SimvastatinSimvastatin results in increased expression of TBXAS1 mRNA20659230
C016104sodium bichromatesodium bichromate results in decreased expression of TBXAS1 mRNA17685462
D018038Sodium SeleniteSodium Selenite results in decreased expression of TBXAS1 mRNA21669866
D018038Sodium SeleniteSodium Selenite results in decreased expression of TBXAS1 protein21669866
D053260SootSoot affects the expression of TBXAS1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TBXAS1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TBXAS1 mRNA26378955
D012460SulfasalazineSulfasalazine results in decreased activity of TBXAS1 protein2572437
D012460Sulfasalazine"[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid"2572437
D012460Sulfasalazine[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B22572437
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TBXAS1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TBXAS1 mRNA21592394
D013749TetrachlorodibenzodioxinTBXAS1 protein results in increased susceptibility to Tetrachlorodibenzodioxin18952116
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBXAS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TBXAS1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBXAS1 mRNA26290441|2821309
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBXAS1 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TBXAS1 protein18951874
D013928Thromboxane A2TBXAS1 protein results in increased chemical synthesis of Thromboxane A218264100
D013929Thromboxane B2[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B22572437
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TBXAS1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TBXAS1 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of TBXAS1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of TBXAS1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of TBXAS1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TBXAS1 mRNA19042947
D014520UrethaneUrethane results in decreased expression of TBXAS1 mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of TBXAS1 protein18479249
D014635Valproic AcidValproic Acid results in increased expression of TBXAS1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of TBXAS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TBXAS1 mRNA15901671
D014639VanadiumVanadium results in decreased expression of TBXAS1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TBXAS1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004497monooxygenase activity-IEA-  
GO:0004796thromboxane-A synthase activity-TAS-  
GO:0005506iron ion binding-IEA-  
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen-IEA-  
GO:0020037heme binding-IEA-  
GO:003613412-hydroxyheptadecatrienoic acid synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006690icosanoid metabolic process-TAS-  
GO:0019371cyclooxygenase pathway-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211979EicosanoidsTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5579032Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)TAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal