Gene: TEAD1

7003
AA|NTEF-1|REF1|TCF-13|TCF13|TEAD-1|TEF-1
TEA domain transcription factor 1
protein-coding
11p15.3
Ensembl:ENSG00000187079 MIM:189967 Vega:OTTHUMG00000165878 UniprotKB:P28347
NG_021302.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.801e-1 (AD)  6.351e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10831916chr11:12889689 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15573664chr11:12833710TEAD1Gene body2.245e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APPL20.884
CPNE30.883
FERMT20.883
SASH10.879
EPB41L50.877
CYBRD10.871
MSI20.869
CAPN20.869
SMURF20.864
SS180.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.413
RTP1-0.407
RHO-0.399
OR4F29-0.396
MYOZ3-0.395
ADRA1D-0.39
AGMAT-0.386
CRH-0.386
ABCC12-0.385
HAS1-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolTEAD1 protein results in decreased susceptibility to 1-UFT protocol16734730
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TEAD1 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of TEAD1 mRNA"27567155
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of TEAD1 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TEAD1 mRNA24449571
D001151ArsenicArsenic affects the methylation of TEAD1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TEAD1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TEAD1 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of TEAD1 mRNA19484750
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TEAD1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TEAD1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of TEAD1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TEAD1 mRNA25181051
D000069287CapecitabineTEAD1 protein results in decreased susceptibility to Capecitabine16734730
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD1 gene20938992
D003042CocaineCocaine affects the expression of TEAD1 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of TEAD1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of TEAD1 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of TEAD1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TEAD1 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TEAD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TEAD1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TEAD1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TEAD1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TEAD1 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of and affects the activity of TEAD1 protein24147051
D004041Dietary Fats[Dietary Fats affects the expression of and affects the activity of TEAD1 protein] which results in decreased expression of PENK protein alternative form24147051
C024629dimethyl phthalatedimethyl phthalate affects the expression of TEAD1 mRNA26924002
C025034doxifluridineTEAD1 protein results in decreased susceptibility to doxifluridine16734730
C540355fenamidonefenamidone results in increased expression of TEAD1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD1 gene20938992
C039281furanfuran results in increased expression of TEAD1 mRNA25539665
C001277geldanamycingeldanamycin results in increased expression of TEAD1 mRNA26705709
D017313FenretinideFenretinide results in decreased expression of TEAD1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TEAD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TEAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TEAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TEAD1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TEAD1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TEAD1 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TEAD1 gene20938992
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TEAD1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of TEAD1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TEAD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TEAD1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of TEAD1 mRNA19167457
C016030pantogabpantogab results in increased expression of TEAD1 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TEAD1 mRNA27153767
D011441PropylthiouracilPropylthiouracil results in increased expression of TEAD1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TEAD1 mRNA27029645
D012822Silicon DioxideSilicon Dioxide results in increased expression of TEAD1 mRNA23221170
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of TEAD1 protein]21245298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TEAD1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TEAD1 mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of TEAD1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of TEAD1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of TEAD1 mRNA23409001
C012589trichostatin Atrichostatin A results in decreased expression of TEAD1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of TEAD1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of TEAD1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TEAD1 gene25560391
C111237vorinostatvorinostat results in decreased expression of TEAD1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP26045994  
GO:0000987proximal promoter sequence-specific DNA binding-IMP26045994  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001134transcription factor activity, transcription factor recruiting-IMP20123905  
GO:0001223transcription coactivator binding-IPI20123905  
GO:0003677DNA binding-TAS8396764  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA18579750  19324877  
GO:0005515protein binding-IPI8423815  8551581  9869635  18579750  19324877  22863277  
24255178  24581491  24882516  25751139  25751140  25796446  
26258633  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046982protein heterodimerization activity-IPI20123905  
GO ID GO Term Qualifier Evidence PubMed
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0035329hippo signaling-IBA21873635  
GO:0035329hippo signaling-IDA18579750  19324877  
GO:0045893positive regulation of transcription, DNA-templated-IMP20123905  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP25796446  
GO:0048568embryonic organ development-IBA21873635  
GO:0065003protein-containing complex assembly-IMP20123905  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IMP26045994  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0071148TEAD-1-YAP complex-IDA20123905  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2032785YAP1- and WWTR1 (TAZ)-stimulated gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8951671RUNX3 regulates YAP1-mediated transcriptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29050244The prognostic impacts of TEA domain (TEAD) transcription factor polymorphisms in Chinese hepatocellular carcinoma patients. (2017 Sep 19)Xia HOncotarget