Gene: TXNRD1

7296
GRIM-12|TR|TR1|TRXR1|TXNR
thioredoxin reductase 1
protein-coding
12q23.3
Ensembl:ENSG00000198431 MIM:601112 Vega:OTTHUMG00000166481 UniprotKB:Q16881
NG_029392.1
PubMed|SNP Mapped
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.186e-1 (AD)  3.669e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10861184chr12:104270315 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25684105chr12:104613662TXNRD16.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GCLM0.883
ZNF4100.858
GALNT20.857
SPTY2D10.853
SEC23B0.85
NAA500.843
LARP40.841
SRXN10.839
SOD20.837
CLIP10.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.503
OR4F29-0.459
SNX22-0.253
KLRK1-0.239
CTNNA3-0.223
C5orf64-0.221
OR6C74-0.218
CETP-0.21
TCL1A-0.209
RERGL-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased activity of TXNRD1 protein"15982805
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 mRNA"28757135
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 protein"28757135
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"Sodium Selenite promotes the reaction [TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane]"28757135
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"28757135
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TXNRD1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of TXNRD1 mRNA]"27071940
C0394111,2-dibromo-2,4-dicyanobutane"1,2-dibromo-2,4-dicyanobutane results in increased expression of TXNRD1 mRNA"23445166
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of and results in increased activity of TXNRD1 protein"25179160
C0493251,2-dithiol-3-thione"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA"22495766
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of TXNRD1 mRNA25596134
C0317631,3-butadiene"1,3-butadiene results in increased expression of TXNRD1 mRNA"21147608
C02508615-hydroperoxy-5,8,11,13-eicosatetraenoic acid"TXNRD1 protein affects the reaction [15-hydroperoxy-5,8,11,13-eicosatetraenoic acid results in increased expression of HMOX1 mRNA]"16209660
C0805011-(5-isoquinolinylsulfonyl)-3-methylpiperazine1-(5-isoquinolinylsulfonyl)-3-methylpiperazine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA"24211530
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA]28329830
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TXNRD1 mRNA"17547211
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TXNRD1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TXNRD1 mRNA"21346803
C0127962-butenal2-butenal results in increased expression of TXNRD1 mRNA20471460
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased activity of TXNRD1 protein20345183
C0312782-chloroethyl ethyl sulfideTXNRD1 protein affects the susceptibility to 2-chloroethyl ethyl sulfide20345183
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of TXNRD1 mRNA20382172
C5780792-cyclohexylselenazolidine-4-carboxylic acid2-cyclohexylselenazolidine-4-carboxylic acid results in increased expression of TXNRD1 mRNA22807314
C5780792-cyclohexylselenazolidine-4-carboxylic acid2-cyclohexylselenazolidine-4-carboxylic acid results in increased expression of TXNRD1 protein22807314
C5780792-cyclohexylselenazolidine-4-carboxylic acidNFE2L2 mutant form inhibits the reaction [2-cyclohexylselenazolidine-4-carboxylic acid results in increased expression of TXNRD1 mRNA]22807314
C4764412-oxoselenazolidine-4-carboxylic acid2-oxoselenazolidine-4-carboxylic acid results in increased expression of TXNRD1 mRNA16451816
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of TXNRD1 mRNA12949356
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of TXNRD1 mRNA16014739
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of TXNRD1 mRNA"24378064
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of TXNRD1 mRNA28790194
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of TXNRD1 mRNA28790194
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one[Tobacco Smoke Pollution co-treated with 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one] results in increased expression of TXNRD1 mRNA28790194
C0006230213-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one results in increased expression of TXNRD1 mRNA28790194
C4171904-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine"4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine results in increased expression of TXNRD1 mRNA"19768707
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of TXNRD1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TXNRD1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TXNRD1 mRNA19191707
C0729564-nitrososulfamethoxazole4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA28444390
C0297284-phenylenediamine4-phenylenediamine results in increased expression of TXNRD1 mRNA23445166
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
C1143697,8-diacetoxy-4-methylcoumarin"7,8-diacetoxy-4-methylcoumarin results in increased expression of TXNRD1 mRNA"24103856
C0307357-aminocephalosporanic acid7-aminocephalosporanic acid results in increased expression of TXNRD1 mRNA24211530
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TXNRD1 mRNA"19936915
C0671348-oxo-7-hydrodeoxyguanosineTXNRD1 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine19896490
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of TXNRD1 mRNA"26238291
D000082AcetaminophenAcetaminophen affects the expression of TXNRD1 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of TXNRD1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TXNRD1 protein22230336
D000082AcetaminophenAcetaminophen affects the expression of TXNRD1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased activity of TXNRD1 protein24661219
D000082AcetaminophenAcetaminophen metabolite results in decreased activity of TXNRD1 protein24661219
D000082AcetaminophenAcetaminophen results in decreased expression of TXNRD1 mRNA17522070
D000082AcetaminophenAcetaminophen results in increased expression of TXNRD1 mRNA17202758|1720276
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
D000171AcroleinAcetylcysteine inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
D000171AcroleinAcrolein results in decreased activity of TXNRD1 protein15388247|1565250
D000171AcroleinAcrolein results in increased expression of TXNRD1 mRNA15652504|2421153
D000171AcroleinCycloheximide inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
D000171AcroleinDactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
C560978aegeline[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
C016601afimoxifeneafimoxifene results in decreased expression of TXNRD1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TXNRD1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TXNRD1 mRNA27153756
D000393Air PollutantsAir Pollutants results in increased expression of TXNRD1 mRNA23649983
D000450AldosteroneAldosterone results in increased expression of TXNRD1 protein24512358
C004471allyl isothiocyanateallyl isothiocyanate results in decreased activity of TXNRD1 protein17937621
C038491allyl sulfideallyl sulfide results in increased activity of TXNRD1 protein17937621
C038491allyl sulfideallyl sulfide results in increased expression of TXNRD1 mRNA19768707
D000638AmiodaroneAmiodarone affects the expression of TXNRD1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TXNRD1 mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in increased expression of TXNRD1 mRNA24211530
D000965AntimonyAntimony results in increased expression of TXNRD1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of TXNRD1 mRNA17547211|2871322
D001149Arsenates[Arsenates co-treated with chromium hexavalent ion] results in increased expression of TXNRD1 mRNA19895865
D001151ArsenicArsenic affects the methylation of TXNRD1 gene25304211
C025657arsenic acidarsenic acid results in increased activity of TXNRD1 protein19429247
C025657arsenic acidarsenic acid results in increased expression of TXNRD1 mRNA19429247
C025657arsenic acidarsenic acid results in increased expression of TXNRD1 protein19429247
C025657arsenic acidSodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]19429247
C006632arsenic trioxidearsenic trioxide affects the expression of TXNRD1 mRNA25873331
C006632arsenic trioxidearsenic trioxide results in decreased activity of TXNRD1 protein17640917
C006632arsenic trioxideTXNRD1 protein results in decreased susceptibility to arsenic trioxide20707922
C006632arsenic trioxidearsenic trioxide binds to TXNRD1 protein17640917
C006632arsenic trioxidearsenic trioxide results in decreased activity of TXNRD1 protein17640917
C006632arsenic trioxideGlutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]17640917
C006632arsenic trioxideNADP affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]17640917
C015001arsenitearsenite results in increased expression of TXNRD1 mRNA18550526
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of TXNRD1 mRNA15894712
C015001arsenitearsenite results in increased activity of TXNRD1 protein19429247
C015001arsenitearsenite results in increased expression of TXNRD1 mRNA15894712|1942924
C015001arsenitearsenite results in increased expression of TXNRD1 protein19429247
C015001arseniteSodium Selenite promotes the reaction [arsenite results in increased activity of TXNRD1 protein]19429247
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TXNRD1 mRNA"18687144
D001241AspirinAspirin results in decreased expression of TXNRD1 mRNA11906190
D001310AuranofinAuranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]19486940
D001310AuranofinAuranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]19486940
D001310AuranofinAuranofin results in decreased activity of TXNRD1 protein18405881|1878931
D001310AuranofinAuranofin results in increased expression of TXNRD1 mRNA19486940
D001310AuranofinAuranofin results in increased oxidation of TXNRD1 protein19486940
D001310Auranofinpotassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]19486940
D001310AuranofinSodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]19486940
D001310AuranofinAuranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]26975474
D001310AuranofinAuranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D001310AuranofinAuranofin results in decreased activity of TXNRD1 protein16510263
D001310AuranofinAuranofin inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D006051AurothioglucoseAurothioglucose results in decreased activity of TXNRD1 protein21172426
D001372Aza CompoundsAza Compounds results in decreased expression of TXNRD1 mRNA20521778
D001372Aza CompoundsAza Compounds results in increased expression of TXNRD1 mRNA20521778
D001379AzathioprineAzathioprine results in increased expression of TXNRD1 mRNA22623647
C051597Bandrowski's baseBandrowski's base results in increased expression of TXNRD1 mRNA20566472
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of TXNRD1 mRNA12949356|1973760
D019817Benzoic AcidBenzoic Acid results in increased expression of TXNRD1 mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TXNRD1 mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of TXNRD1 mRNA]15034205
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of TXNRD1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TXNRD1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TXNRD1 mRNA15034205|1589471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TXNRD1 mRNA"19150397
C031403benzyl isothiocyanatebenzyl isothiocyanate results in decreased activity of TXNRD1 protein17937621
C031403benzyl isothiocyanateNADP affects the reaction [benzyl isothiocyanate results in decreased activity of TXNRD1 protein]17937621
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of TXNRD1 mRNA18550526
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to TXNRD1 protein]23665804
D004958EstradiolEstradiol results in increased expression of TXNRD1 mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of TXNRD1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TXNRD1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TXNRD1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of TXNRD1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of TXNRD1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TXNRD1 mRNA21601586
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of TXNRD1 mRNA17553608
C013418bromfenacoumbromfenacoum results in increased expression of TXNRD1 protein28903499
D001973Bromodeoxyuridine[Bromodeoxyuridine co-treated with furan] results in increased expression of TXNRD1 mRNA24910943
D002066BusulfanBusulfan results in decreased activity of TXNRD1 protein16085187
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
D019328Buthionine SulfoximineButhionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]12663510
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of TXNRD1 mRNA12663510
D019328Buthionine SulfoximineTXNRD1 gene mutant form results in increased susceptibility to Buthionine Sulfoximine24853413
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of TXNRD1 mRNA19010381
D019328Buthionine Sulfoximine[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein16288907
D020122tert-ButylhydroperoxideMT2A protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of TXNRD1 mRNA]16636651
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TXNRD1 mRNA12414654|1663665
C584509C646 compoundC646 compound results in decreased expression of TXNRD1 mRNA26191083
D002101Cacodylic Acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXNRD1 mRNA23192986
D002104CadmiumCadmium results in increased expression of TXNRD1 mRNA23256528
D002104CadmiumCadmium results in increased expression of TXNRD1 mRNA17547211|2112074
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TXNRD1 mRNA15521073
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TXNRD1 mRNA19031917
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [NFE2L2 protein binds to TXNRD1 promoter]15521073
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TXNRD1 mRNA15521073|1754721
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TXNRD1 mRNA22677785
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TXNRD1 mRNA19010381
C037123cadmium sulfatecadmium sulfate results in increased expression of TXNRD1 mRNA21783983
C037123cadmium sulfatecadmium sulfate results in increased expression of TXNRD1 mRNA16221973
D002110CaffeineCaffeine results in decreased expression of TXNRD1 mRNA18444173
D002110Caffeine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
C005563captaxcaptax results in increased expression of TXNRD1 mRNA24211530
C005563captaxcaptax results in increased expression of TXNRD1 mRNA23445166
D002220CarbamazepineCarbamazepine affects the expression of TXNRD1 mRNA24752500|2597931
D002220CarbamazepineCarbamazepine results in increased expression of TXNRD1 mRNA17381134
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TXNRD1 mRNA25471833
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of TXNRD1 protein18215477
D002251Carbon TetrachlorideQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TXNRD1 mRNA]25471833
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TXNRD1 mRNA17522070
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TXNRD1 mRNA17202758
D002330Carmustine[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein16288907
D002330CarmustineCarmustine results in decreased activity of TXNRD1 protein16085187
D002392CatechinCatechin results in decreased activity of TXNRD1 protein modified form16618767
C026690cerous chloridecerous chloride results in increased expression of TXNRD1 mRNA28954213
D002599ChalconeChalcone results in increased expression of TXNRD1 mRNA17320913
D002599ChalconeChalcone results in increased expression of TXNRD1 protein17320913
D002699ChlorambucilChlorambucil results in decreased activity of TXNRD1 protein16085187
C001599chloritechlorite results in decreased activity of TXNRD1 protein27478981
C004656chloroacetaldehydechloroacetaldehyde affects the expression of TXNRD1 mRNA25596134
C031294chlorobenzenechlorobenzene results in increased expression of TXNRD1 mRNA19800902
D002725ChloroformChloroform results in decreased expression of TXNRD1 mRNA17522070
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of TXNRD1 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of TXNRD1 mRNA24211530|2635216
D002737ChloropreneChloroprene results in increased expression of TXNRD1 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of TXNRD1 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of TXNRD1 mRNA25064622
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
C000474cholestane-3,5,6-triol"cholestane-3,5,6-triol results in increased expression of TXNRD1 mRNA"16039982
C000474cholestane-3,5,6-triol"Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of TXNRD1 mRNA]"16039982
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
C074702chromium hexavalent ion[Arsenates co-treated with chromium hexavalent ion] results in increased expression of TXNRD1 mRNA19895865
C059262cidofovircidofovir results in increased expression of TXNRD1 mRNA25596134
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of TXNRD1 mRNA19000754|2421153
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of TXNRD1 protein18304597
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of TXNRD1 mRNA20566472
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of TXNRD1 mRNA23445166
D004002Clodronic AcidClodronic Acid results in increased expression of TXNRD1 mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of TXNRD1 mRNA17585979
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of TXNRD1 mRNA23052192
C018021cobaltous chloridecobaltous chloride results in increased expression of TXNRD1 mRNA22941251
C018021cobaltous chloridecobaltous chloride results in increased expression of TXNRD1 mRNA24386269
C004690coclaurine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
D009249NADPNADP affects the reaction [benzyl isothiocyanate results in decreased activity of TXNRD1 protein]17937621
D009249NADP[NADP co-treated with Mechlorethamine] results in decreased activity of TXNRD1 protein24274902
D009249NADPAuranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]26975474
D009249NADPAuranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADPDinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADPDithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADPformic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADPGlutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]22694104
D009249NADPmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADP[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein22694104
D009249NADPNADP affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]17640917
D009249NADP[NADP co-treated with Mechlorethamine] promotes the reaction [TXNRD1 protein binds to TXNRD1 protein]24274902
D009249NADP[NADP co-treated with Mechlorethamine] results in decreased activity of and results in increased alkylation of TXNRD1 protein24274902
D009249NADP[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein26975474
D009249NADPNADP results in increased reduction of TXNRD1 protein22694104
D009249NADPOxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADPPentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADP[Sodium Selenite co-treated with NADP] inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D009249NADPSodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADP[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D009249NADP[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides20457604
C075384coniferaldehydeconiferaldehyde results in increased expression of TXNRD1 mRNA26275128
D003300CopperCopper results in increased expression of TXNRD1 mRNA20875833
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of TXNRD1 mRNA25167922
D003300CopperCopper results in increased expression of TXNRD1 mRNA19781568
D019327Copper SulfateCopper Sulfate results in increased expression of TXNRD1 mRNA19549813
C030123coumarincoumarin results in increased expression of TXNRD1 mRNA18480146
C029892cupric chloridecupric chloride results in increased expression of TXNRD1 mRNA17211630
D003474CurcuminCurcumin analog results in increased expression of TXNRD1 mRNA26409325
D003474CurcuminCurcumin results in increased expression of TXNRD1 mRNA17198877
D003474CurcuminCurcumin results in increased oxidation of TXNRD1 protein21782934
D003474CurcuminCurcumin results in increased expression of TXNRD1 mRNA18299980
C057862cyanoginosin LRcyanoginosin LR results in increased expression of TXNRD1 mRNA17654400
D003513CycloheximideCycloheximide inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
D003513CycloheximideCycloheximide inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
D003520CyclophosphamideCyclophosphamide results in decreased activity of TXNRD1 protein19168513
D016572CyclosporineCyclosporine affects the expression of TXNRD1 mRNA25064622
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D016572CyclosporineCyclosporine results in increased expression of TXNRD1 mRNA20106945|2559613
D016572CyclosporineCyclosporine results in increased expression of TXNRD1 mRNA19224547
C089595cylindrospermopsincylindrospermopsin results in increased expression of TXNRD1 mRNA23726867
D003545CysteineTXNRD1 gene mutant form inhibits the reaction [diphenyldiselenide results in increased abundance of Cysteine]23360449
D003609DactinomycinDactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]15652504
D003609DactinomycinDactinomycin inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C515055darinaparsindarinaparsin results in increased expression of TXNRD1 mRNA23426167
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD1 mRNA28659758
D013759DronabinolDronabinol results in increased expression of TXNRD1 mRNA18454173
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TXNRD1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of TXNRD1 mRNA25047013
D002945CisplatinCisplatin promotes the reaction [TXNRD1 protein binds to TXN1 protein]20851179
D002945CisplatinCisplatin promotes the reaction [TXNRD1 protein binds to TXNDC17 protein]20851179
D002945CisplatinCisplatin results in decreased activity of TXNRD1 protein21172426
D002945CisplatinCisplatin results in increased expression of TXNRD1 mRNA25450742|2559613
D002945CisplatinTXNRD1 protein results in decreased susceptibility to Cisplatin10490269
D002945Cisplatin[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA24865317
D002945CisplatinCisplatin results in decreased expression of TXNRD1 mRNA24865317
D002945CisplatinCisplatin results in decreased activity of TXNRD1 protein16085187
D002945CisplatinCisplatin results in increased expression of TXNRD1 mRNA22023808
D004008DiclofenacDiclofenac affects the expression of TXNRD1 mRNA24752500
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXNRD1 protein"25772430
C121718dicyclanil[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of TXNRD1 mRNA17162532
C121718dicyclanildicyclanil results in increased expression of TXNRD1 mRNA15664270
C014476diethyl maleatediethyl maleate results in increased expression of TXNRD1 mRNA15521073
C014476diethyl maleatediethyl maleate results in increased expression of TXNRD1 mRNA15521073
D004052Diethylnitrosamine[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of TXNRD1 mRNA17162532
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TXNRD1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TXNRD1 mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of TXNRD1 mRNA16002434
D004112DimercaprolDimercaprol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TXNRD1 mRNA27638505
C062856dimethylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXNRD1 mRNA25873331
C060658dimethyl mercaptosuccinatedimethyl mercaptosuccinate inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TXNRD1 mRNA17547211
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of TXNRD1 mRNA17374397|2014638
D004137DinitrochlorobenzeneDinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased oxidation of TXNRD1 protein21782934
D004137Dinitrochlorobenzene[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D004137DinitrochlorobenzeneDinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of TXNRD1 mRNA23445166
C061132diphenyldiselenideTXNRD1 gene mutant form inhibits the reaction [diphenyldiselenide results in increased abundance of Cysteine]23360449
C061132diphenyldiselenideTXNRD1 gene mutant form results in decreased susceptibility to diphenyldiselenide23360449
C061132diphenyldiselenidediphenyldiselenide results in increased expression of and affects the localization of TXNRD1 protein23360449
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Paraquat results in increased activity of TXNRD1 protein]17229725
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D004178DiquatDiquat results in increased expression of TXNRD1 mRNA21172416
D004178DiquatDiquat results in increased expression of TXNRD1 mRNA20826540
D004221DisulfiramDisulfiram results in increased expression of TXNRD1 mRNA20566472
D004228Dithionitrobenzoic AcidTXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid21172426
D004228Dithionitrobenzoic AcidDinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D004228Dithionitrobenzoic Aciddiphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D004228Dithionitrobenzoic AcidGold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D004228Dithionitrobenzoic AcidTXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid17229725
D004228Dithionitrobenzoic Acid[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D004228Dithionitrobenzoic AcidDithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D004228Dithionitrobenzoic AcidFerrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D004228Dithionitrobenzoic AcidTXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid20457604
D004228Dithionitrobenzoic AcidAuranofin inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TXNRD1 mRNA"23811387
D004492Edetic AcidEdetic Acid results in increased activity of TXNRD1 protein16774913
D004492Edetic AcidZinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]16774913
C512195elesclomolelesclomol results in increased expression of TXNRD1 mRNA18723479
D004642EmodinEmodin results in decreased expression of TXNRD1 mRNA16045814
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TXNRD1 protein23301498
D004811EpichlorohydrinEpichlorohydrin results in increased expression of TXNRD1 mRNA24211530
C045651epigallocatechin gallateepigallocatechin gallate affects the expression of and affects the activity of TXNRD1 protein25585349
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of TXNRD1 mRNA25585349
C073539erucinerucin results in increased expression of and results in increased activity of TXNRD1 protein15740016
C073539erucinerucin results in increased expression of TXNRD1 mRNA15740016
C073539erucinSelenium promotes the reaction [erucin results in increased expression of and results in increased activity of TXNRD1 protein]15740016
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of TXNRD1 mRNA17522070
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TXNRD1 mRNA25064622
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TXNRD1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TXNRD1 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TXNRD1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TXNRD1 mRNA16174780
D005054EugenolEugenol results in increased expression of TXNRD1 mRNA20566472
D005054EugenolEugenol results in increased expression of TXNRD1 mRNA23445166
C047360felbamatefelbamate results in increased expression of TXNRD1 mRNA17381134
C540355fenamidonefenamidone results in increased expression of TXNRD1 mRNA27029645
D011345FenofibrateFenofibrate results in increased expression of TXNRD1 mRNA25596134
D005296Ferrous CompoundsFerrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]20457604
D005411Flame RetardantsFlame Retardants results in increased expression of TXNRD1 mRNA19858236
D005436FloxacillinFloxacillin results in increased expression of TXNRD1 mRNA28444390
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA]28329830
D005472FluorouracilFluorouracil results in decreased expression of TXNRD1 mRNA19219653
D005485FlutamideFlutamide results in increased expression of TXNRD1 mRNA24136188
C030544formic acidformic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
C070081fulvestrantfulvestrant results in decreased expression of TXNRD1 mRNA16514628
C039281furan[Bromodeoxyuridine co-treated with furan] results in increased expression of TXNRD1 mRNA24910943
C039281furanfuran results in increased expression of TXNRD1 mRNA24183702|2491094
C039281furanfuran results in increased activity of TXNRD1 protein27402187
D008299Maleic AnhydridesMaleic Anhydrides results in increased expression of TXNRD1 mRNA24211530
C040029gabapentingabapentin results in increased expression of TXNRD1 mRNA17381134
D005690GalactoseGalactose results in decreased expression of TXNRD1 mRNA23274001
D005690Galactosesodium bisulfide inhibits the reaction [Galactose results in decreased expression of TXNRD1 mRNA]23274001
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of TXNRD1 mRNA20664735
C106014geduningedunin results in increased expression of TXNRD1 mRNA17010675
D019833GenisteinGenistein results in increased expression of TXNRD1 mRNA18444173
D005978GlutathioneGlutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]17640917
D005978GlutathioneGlutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]22694104
D005978GlutathioneGlutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]24661219
C071834glycidamideglycidamide results in increased expression of TXNRD1 mRNA17822822
D006037GlyoxalGlyoxal results in increased expression of TXNRD1 mRNA23445166
D006046GoldGold results in decreased activity of TXNRD1 protein20851179
D006046GoldGold results in decreased activity of TXNRD1 protein16510263
D017612Gold CompoundsGold Compounds results in decreased activity of TXNRD1 protein16510263
D006052Gold Sodium ThiomalateGold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]17229725
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased activity of TXNRD1 protein16510263
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of TXNRD1 mRNA23153324
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of TXNRD1 mRNA23153324
C001335hexachlorobutadienehexachlorobutadiene results in increased expression of TXNRD1 mRNA21905055
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA20566472
C012348higenamine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TXNRD1 mRNA15521073
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TXNRD1 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TXNRD1 mRNA12414654|1552107
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TXNRD1 protein28544404
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of TXNRD1 protein]28544404
D006861Hydrogen PeroxideTXNRD1 protein mutant form results in decreased reduction of Hydrogen Peroxide10849437
D006861Hydrogen PeroxideTXNRD1 protein results in increased reduction of Hydrogen Peroxide10849437
D047348Hydrolyzable Tannins[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
C031927hydroquinonehydroquinone results in increased expression of TXNRD1 mRNA15452088
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of TXNRD1 mRNA17572062
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of TXNRD1 mRNA18156441
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of TXNRD1 mRNA19376150
C082585iberiniberin results in increased expression of and results in increased activity of TXNRD1 protein15740016
C082585iberiniberin results in increased expression of TXNRD1 mRNA15740016
C082585iberinSelenium promotes the reaction [iberin results in increased expression of and results in increased activity of TXNRD1 protein]15740016
C492448ICG 001ICG 001 results in decreased expression of TXNRD1 mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of TXNRD1 mRNA25596134
D007211IndolesIndoles results in decreased expression of TXNRD1 mRNA20521778
D007211IndolesIndoles results in increased expression of TXNRD1 mRNA20521778
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TXNRD1 mRNA25613284
C051890irinotecanirinotecan affects the expression of TXNRD1 mRNA20097248
C036643isoeugenolisoeugenol results in increased expression of TXNRD1 mRNA20566472
C036643isoeugenolisoeugenol results in increased expression of TXNRD1 mRNA23445166
D007529IsoflavonesIsoflavones results in increased expression of TXNRD1 mRNA17374662
D007538IsoniazidIsoniazid results in increased expression of TXNRD1 mRNA28444390
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of TXNRD1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound analog binds to TXNRD1 protein24972113
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TXNRD1 mRNA24796395
C005134jugloneTXNRD1 protein results in increased reduction of juglone21172426
C410337K 7174K 7174 results in increased expression of TXNRD1 mRNA24086573
D019344Lactic AcidLactic Acid results in increased expression of TXNRD1 mRNA20566472
C008261lead acetatelead acetate results in increased expression of TXNRD1 mRNA27562236
C008261lead acetatelead acetate results in increased expression of TXNRD1 mRNA24345272
C008261lead acetatelead acetate results in increased expression of TXNRD1 protein24345272
C045463leflunomideleflunomide results in increased expression of TXNRD1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of TXNRD1 mRNA24136188
C013091lipoamideTXNRD1 protein results in increased reduction of lipoamide21172426
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TXNRD1 protein"25772430
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TXNRD1 protein"25772430
D008095Lithocholic Acid[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA17724089
D008095Lithocholic AcidLithocholic Acid results in increased expression of TXNRD1 mRNA20977460
D008095Lithocholic AcidLithocholic Acid results in increased expression of TXNRD1 protein20977460
D008095Lithocholic AcidNFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]20977460
D008095Lithocholic AcidNFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]20977460
D014975Lutein[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA24865317
D014975LuteinLutein results in decreased expression of TXNRD1 mRNA24865317
D008344Maneb[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA21402726
C025340manganese chloridemanganese chloride results in increased expression of TXNRD1 mRNA22281203
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D008466Mechlorethamine[NADP co-treated with Mechlorethamine] results in decreased activity of TXNRD1 protein24274902
D008466Mechlorethamine[NADP co-treated with Mechlorethamine] promotes the reaction [TXNRD1 protein binds to TXNRD1 protein]24274902
D008466Mechlorethamine[NADP co-treated with Mechlorethamine] results in decreased activity of and results in increased alkylation of TXNRD1 protein24274902
D008558MelphalanMelphalan results in decreased activity of TXNRD1 protein16085187
C042720mercuric bromidemercuric bromide results in increased expression of TXNRD1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of TXNRD1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]24816296
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of TXNRD1 protein17959236|2081078
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TXNRD1 mRNA24816296
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TXNRD1 protein24816296
D008627Mercuric ChlorideSodium Selenite inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008627Mercuric ChlorideSodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 mRNA]24816296
D008627Mercuric ChlorideSodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 protein]24816296
D008627Mercuric ChlorideDimercaprol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008627Mercuric Chloridedimethyl mercaptosuccinate inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of TXNRD1 protein18321861|2081078
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TXNRD1 mRNA16507785
D008627Mercuric Chloride[Sodium Selenite co-treated with NADP] inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008627Mercuric ChlorideThioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008627Mercuric ChlorideUnithiol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D008628MercuryMercury results in increased expression of TXNRD1 mRNA17547211
D008687MetforminMetformin results in increased expression of TXNRD1 mRNA25596134
D008701MethapyrileneMethapyrilene results in increased expression of TXNRD1 mRNA16393664|2893558
D008727MethotrexateMethotrexate results in increased expression of TXNRD1 mRNA21678067
C543395methylarsine[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXNRD1 mRNA25873331
D008751Methylene BlueMethylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]24556215
C002950methylformamidemethylformamide affects the expression of TXNRD1 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of TXNRD1 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride affects the expression of TXNRD1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride inhibits the reaction [Sodium Selenite results in increased expression of TXNRD1 protein]24816296
C004925methylmercuric chloridemethylmercuric chloride results in decreased activity of TXNRD1 protein24816296
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TXNRD1 protein24816296
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TXNRD1 mRNA23179753|2481629
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TXNRD1 mRNA27456245
C004925methylmercuric chloridemethylmercuric chloride results in decreased activity of TXNRD1 protein20810785
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TXNRD1 protein22885222
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased activity of TXNRD1 protein18321861
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TXNRD1 mRNA23832298
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TXNRD1 protein23832298
C030957methylmercury IImethylmercury II results in increased expression of TXNRD1 mRNA17905399
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TXNRD1 mRNA"20188158
C033069methyl salicylatemethyl salicylate results in increased expression of TXNRD1 mRNA20566472
C008493methylselenic acidTXNRD1 protein results in increased metabolism of methylselenic acid11782468
C008493methylselenic acidTXNRD1 protein results in increased metabolism of methylselenic acid11782468
C008493methylselenic acidTXNRD1 protein results in decreased susceptibility to methylselenic acid19782697
D015741MetriboloneMetribolone results in decreased expression of TXNRD1 protein17152098
D008825MiconazoleMiconazole results in decreased expression of TXNRD1 mRNA22262564
D016685MitomycinGlutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]22694104
D016685Mitomycin[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein22694104
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of TXNRD1 mRNA23360888
C020300monomethylarsonic acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXNRD1 mRNA23192986
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of and results in decreased activity of TXNRD1 protein19095002
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TXNRD1 mRNA19095002|2088654
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of TXNRD1 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA16357179
C040015myricetinmyricetin results in decreased activity of TXNRD1 protein modified form16618767
C040015myricetinNitrogen inhibits the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]16618767
C040015myricetin[Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]16618767
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of TXNRD1 mRNA16129123
C028473N-acetyl-4-benzoquinoneimineGlutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]24661219
C028473N-acetyl-4-benzoquinoneimineN-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein24661219
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TXNRD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TXNRD1 mRNA"25554681
C031721naphthalenenaphthalene analog results in increased expression of TXNRD1 mRNA24976557
D009285NaphthoquinonesNaphthoquinones results in increased expression of TXNRD1 mRNA23811387
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of TXNRD1 mRNA17522070
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TXNRD1 mRNA20551477
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TXNRD1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of TXNRD1 mRNA24136188
C026385n-hexanen-hexane results in increased expression of TXNRD1 mRNA20566472
D009532NickelNickel results in increased expression of TXNRD1 mRNA12540486
C022838nickel chloridenickel chloride results in increased expression of TXNRD1 mRNA17547211
C022838nickel chloridenickel chloride affects the expression of TXNRD1 mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of TXNRD1 mRNA17374397|2056647
C029938nickel sulfatenickel sulfate affects the expression of TXNRD1 mRNA12718980
C012655nimesulidenimesulide results in increased expression of TXNRD1 mRNA24136188
D009569Nitric OxideTXNRD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]8810647
D009584NitrogenNitrogen inhibits the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]16618767
D009584NitrogenNitrogen inhibits the reaction [Quercetin results in decreased activity of TXNRD1 protein modified form]16618767
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of TXNRD1 mRNA27206323
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of TXNRD1 mRNA17616710
C010615Nonidet P-40Nonidet P-40 results in increased expression of TXNRD1 mRNA26552463
C570897NSC668394NSC668394 results in increased expression of TXNRD1 mRNA27137931
C025589ochratoxin Aochratoxin A results in decreased expression of TXNRD1 mRNA23358140
C026209oltiprazoltipraz results in increased expression of TXNRD1 mRNA16451816
C016340o,p'-DDT"o,p'-DDT affects the expression of TXNRD1 mRNA"17984292
D050607Organogold CompoundsOrganogold Compounds results in decreased activity of TXNRD1 protein21172426
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of TXNRD1 mRNA25167922
C030110oxaliplatinoxaliplatin results in decreased activity of TXNRD1 protein16085187
D010081OxazoloneOxazolone results in increased expression of TXNRD1 mRNA17374397
D010100OxygenOxygen deficiency results in decreased expression of TXNRD1 mRNA25596134
D010100OxygenOxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D010126OzoneOzone results in increased expression of TXNRD1 mRNA27206323
D010126OzoneOzone results in increased expression of TXNRD1 mRNA17095637
D010165PalladiumPalladium results in decreased activity of TXNRD1 protein20851179
D010269ParaquatParaquat affects the expression of TXNRD1 mRNA25064622
D010269Paraquatdiphenyleneiodonium inhibits the reaction [Paraquat results in increased activity of TXNRD1 protein]17229725
D010269ParaquatParaquat results in increased activity of TXNRD1 protein17229725
D010269ParaquatParaquat results in increased expression of TXNRD1 mRNA12954614
D010269ParaquatParaquat affects the expression of TXNRD1 mRNA16854511
D010269ParaquatParaquat results in decreased activity of TXNRD1 protein17055214
D010269ParaquatSelenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein]17055214
D052638Particulate MatterParticulate Matter results in increased expression of TXNRD1 mRNA28341207
C066957pelargonidinpelargonidin results in decreased activity of TXNRD1 protein modified form16618767
D010416PentachlorophenolPentachlorophenol results in increased expression of TXNRD1 mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of TXNRD1 mRNA23892564
D004369Pentetic AcidPentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of TXNRD1 protein26178269
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of TXNRD1 mRNA17383973
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TXNRD1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TXNRD1 mRNA19162173
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD1 mRNA28659758
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased activity of TXNRD1 protein17937621
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of TXNRD1 mRNA20442190
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of TXNRD1 mRNA17616710
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of TXNRD1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TXNRD1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TXNRD1 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of TXNRD1 mRNA17381134|1916217
D019800PhenolPhenol results in increased expression of TXNRD1 mRNA17547211
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TXNRD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TXNRD1 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of TXNRD1 mRNA17381134
C018637phoronephorone affects the expression of TXNRD1 mRNA18198479
D010705PhosgenePhosgene affects the expression of TXNRD1 mRNA16300373
C030090phosphoramide mustardphosphoramide mustard results in increased expression of TXNRD1 mRNA27888070
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of TXNRD1 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TXNRD1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TXNRD1 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of TXNRD1 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of TXNRD1 protein18304597
C014758plumbaginplumbagin results in increased expression of TXNRD1 mRNA20028456
C026899potassium tellurate(IV)potassium tellurate(IV) affects the oxidation of TXNRD1 protein19486940
C026899potassium tellurate(IV)potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]19486940
C026899potassium tellurate(IV)potassium tellurate(IV) results in increased activity of TXNRD1 protein19486940
C026899potassium tellurate(IV)potassium tellurate(IV) results in increased expression of TXNRD1 mRNA19486940
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TXNRD1 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of TXNRD1 mRNA23018184
D0198402-Propanol2-Propanol results in increased expression of TXNRD1 mRNA20566472
C031280pyrazolepyrazole results in increased expression of TXNRD1 mRNA17945193
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of TXNRD1 mRNA28659758
D011794QuercetinQuercetin results in increased expression of TXNRD1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TXNRD1 mRNA]25471833
D011794QuercetinNitrogen inhibits the reaction [Quercetin results in decreased activity of TXNRD1 protein modified form]16618767
D011794QuercetinQuercetin affects the expression of TXNRD1 mRNA18178720
D011794QuercetinQuercetin results in decreased activity of TXNRD1 protein modified form16618767
C502851quinocetonequinocetone results in decreased expression of TXNRD1 mRNA27046791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of TXNRD1 mRNA16514628
C059514resveratrolresveratrol results in increased activity of TXNRD1 protein17261084
C059514resveratrolresveratrol results in decreased expression of TXNRD1 protein25952010
D012402RotenoneRotenone results in increased expression of TXNRD1 mRNA17657281|2318674
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of TXNRD1 mRNA"16678137
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of TXNRD1 mRNA]28329830
C014811selenaprolineTXNRD1 protein results in decreased susceptibility to selenaproline analog20920480
D020887Selenious AcidSelenious Acid results in increased activity of TXNRD1 protein24853413
D012643SeleniumSelenium promotes the reaction [erucin results in increased expression of and results in increased activity of TXNRD1 protein]15740016
D012643SeleniumSelenium promotes the reaction [iberin results in increased expression of and results in increased activity of TXNRD1 protein]15740016
D012643SeleniumSelenium promotes the reaction [Selenium results in increased expression of TXNRD1 protein]17150329
D012643SeleniumSelenium promotes the reaction [sulforafan results in increased expression of and results in increased activity of TXNRD1 protein]15740016
D012643SeleniumSelenium results in increased activity of TXNRD1 protein12949356|1547185
D012643SeleniumSelenium results in increased expression of and results in increased activity of TXNRD1 protein15740016
D012643SeleniumSelenium results in increased expression of TXNRD1 protein17150329
D012643Selenium[sulforafan co-treated with Selenium] results in increased activity of TXNRD1 protein12949356
D012643SeleniumSelenium affects the activity of TXNRD1 protein19076066
D012643SeleniumSelenium deficiency results in decreased expression of TXNRD1 mRNA16170372
D012643SeleniumSelenium deficiency results in decreased expression of TXNRD1 protein16170372
D012643SeleniumSelenium affects the activity of TXNRD1 protein19351701
D012643SeleniumSelenium deficiency results in decreased expression of TXNRD1 mRNA15792362
D012643SeleniumSelenium deficiency results in increased expression of TXNRD1 mRNA12667700
D012643SeleniumSelenium results in increased activity of TXNRD1 protein19022953
D012643SeleniumSelenium results in increased expression of TXNRD1 mRNA15792362|1902295
D012643SeleniumSelenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein]17055214
D012643SeleniumSelenium results in increased activity of TXNRD1 protein17055214
D012643SeleniumSelenium results in increased expression of TXNRD1 mRNA16908641
C009226selenocystineNFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]22807314
C009226selenocystineselenocystine results in increased expression of TXNRD1 mRNA22807314
C009226selenocystineselenocystine results in increased expression of TXNRD1 protein22807314
C009226selenocystineTXNRD1 protein results in decreased susceptibility to selenocystine20920480
D012645SelenomethionineSelenomethionine results in increased expression of TXNRD1 mRNA22807314
D012645SelenomethionineSelenomethionine results in increased expression of TXNRD1 protein22807314
C078903seocalcitolseocalcitol results in increased expression of TXNRD1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TXNRD1 mRNA22627296
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of TXNRD1 protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of TXNRD1 mRNA25351596
D012834SilverNFE2L2 protein promotes the reaction [Silver results in increased expression of TXNRD1 mRNA]22036727
D012834SilverSilver results in increased expression of TXNRD1 mRNA22036727|2601428
D012834SilverSilver results in increased expression of TXNRD1 mRNA22576574|2713190
D012834SilverSilver results in decreased activity of TXNRD1 protein21965219
D019821SimvastatinSimvastatin results in decreased expression of TXNRD1 mRNA16414398
C009277sodium arsenatesodium arsenate results in increased expression of TXNRD1 mRNA16882884|2392266
C009277sodium arsenatesodium arsenate results in increased expression of TXNRD1 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of TXNRD1 mRNA15521073
C017947sodium arsenite[sodium arsenite co-treated with dimethylarsine analog co-treated with methylarsine analog] affects the expression of TXNRD1 mRNA25873331
C017947sodium arsenite[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of TXNRD1 mRNA23192986
C017947sodium arsenitesodium arsenite results in increased expression of TXNRD1 mRNA12377979|1267905
C017947sodium arsenitesodium arsenite results in increased expression of TXNRD1 protein28512695
C017947sodium arsenitesodium arsenite results in increased expression of TXNRD1 mRNA16014739
C017947sodium arsenitesodium arsenite results in decreased expression of TXNRD1 mRNA23603382
C017947sodium arseniteSodium Selenite inhibits the reaction [sodium arsenite results in decreased expression of TXNRD1 mRNA]23603382
C016104sodium bichromatesodium bichromate results in decreased expression of TXNRD1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of TXNRD1 mRNA22155349
C025451sodium bisulfidesodium bisulfide inhibits the reaction [Galactose results in decreased expression of TXNRD1 mRNA]23274001
C025451sodium bisulfidesodium bisulfide inhibits the reaction [uranyl acetate results in decreased expression of TXNRD1 protein]26523793
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of TXNRD1 mRNA20566472
D018038Sodium SeleniteAuranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]19486940
D018038Sodium SeleniteAuranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]19486940
D018038Sodium SeleniteButhionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]12663510
D018038Sodium SeleniteMercuric Chloride promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]24816296
D018038Sodium Selenitemethylmercuric chloride inhibits the reaction [Sodium Selenite results in increased expression of TXNRD1 protein]24816296
D018038Sodium Selenite"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 mRNA"28757135
D018038Sodium Selenite"[Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 protein"28757135
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D018038Sodium SeleniteSodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]19486940
D018038Sodium SeleniteSodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 mRNA]24816296
D018038Sodium SeleniteSodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 protein]24816296
D018038Sodium SeleniteSodium Selenite promotes the reaction [sulforafan results in increased activity of TXNRD1 protein]12663510
D018038Sodium SeleniteSodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
D018038Sodium SeleniteSodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 protein]12663510
D018038Sodium Selenite"Sodium Selenite promotes the reaction [TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane]"28757135
D018038Sodium SeleniteSodium Selenite results in decreased activity of TXNRD1 protein18405881
D018038Sodium SeleniteSodium Selenite results in decreased expression of TXNRD1 protein18405881
D018038Sodium SeleniteSodium Selenite results in increased activity of TXNRD1 protein12663510|1294935
D018038Sodium SeleniteSodium Selenite results in increased expression of and results in increased activity of TXNRD1 protein25179160
D018038Sodium SeleniteSodium Selenite results in increased expression of TXNRD1 mRNA18405881|1948694
D018038Sodium SeleniteSodium Selenite results in increased expression of TXNRD1 mRNA alternative form18405881
D018038Sodium SeleniteSodium Selenite results in increased expression of TXNRD1 protein12663510|1840588
D018038Sodium SeleniteSodium Selenite results in increased oxidation of TXNRD1 protein19486940
D018038Sodium Selenite[sulforafan co-treated with Sodium Selenite] results in increased activity of TXNRD1 protein12949356
D018038Sodium SeleniteSodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]19429247
D018038Sodium SeleniteSodium Selenite promotes the reaction [arsenite results in increased activity of TXNRD1 protein]19429247
D018038Sodium SeleniteSodium Selenite results in increased activity of TXNRD1 protein18215477
D018038Sodium SeleniteSodium Selenite affects the expression of TXNRD118209489
D018038Sodium Selenite[Sodium Selenite co-treated with NADP] inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D018038Sodium Selenite"Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of TXNRD1 mRNA]"16039982
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of TXNRD1 protein]28544404
D018038Sodium SeleniteSodium Selenite inhibits the reaction [sodium arsenite results in decreased expression of TXNRD1 mRNA]23603382
D018038Sodium SeleniteSodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D018038Sodium SeleniteSodium Selenite results in increased activity of TXNRD1 protein12449240
D018038Sodium SeleniteSodium Selenite results in increased expression of TXNRD1 mRNA12449240
D018038Sodium SeleniteTXNRD1 protein results in increased reduction of Sodium Selenite20457604
D053260SootSoot results in increased expression of TXNRD1 mRNA26551751
C471405sorafenibsorafenib results in increased expression of TXNRD1 mRNA26409325
D013311StreptozocinStreptozocin results in increased expression of TXNRD1 mRNA12398930
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of TXNRD1 mRNA16214533
C016766sulforafan1-(5-isoquinolinylsulfonyl)-3-methylpiperazine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C016766sulforafanButhionine Sulfoximine inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C016766sulforafanCycloheximide inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C016766sulforafanDactinomycin inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C016766sulforafanNFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of TXNRD1 mRNA]22807314
C016766sulforafanNFE2L2 mutant form inhibits the reaction [sulforafan results in increased expression of TXNRD1 protein]22807314
C016766sulforafanSelenium promotes the reaction [sulforafan results in increased expression of and results in increased activity of TXNRD1 protein]15740016
C016766sulforafanSodium Selenite promotes the reaction [sulforafan results in increased activity of TXNRD1 protein]12663510
C016766sulforafanSodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 mRNA]12663510
C016766sulforafanSodium Selenite promotes the reaction [sulforafan results in increased expression of TXNRD1 protein]12663510
C016766sulforafan[sulforafan co-treated with Selenium] results in increased activity of TXNRD1 protein12949356
C016766sulforafan[sulforafan co-treated with Sodium Selenite] results in increased activity of TXNRD1 protein12949356
C016766sulforafansulforafan results in decreased activity of TXNRD1 protein17937621
C016766sulforafansulforafan results in increased activity of TXNRD1 protein12663510|1294935
C016766sulforafansulforafan results in increased expression of and results in increased activity of TXNRD1 protein15740016
C016766sulforafansulforafan results in increased expression of TXNRD1 mRNA12663510|1294935
C016766sulforafansulforafan results in increased expression of TXNRD1 protein12663510|1715032
C016766sulforafansulforafan results in increased expression of TXNRD1 mRNA19303893
C016766sulforafansulforafan results in increased expression of TXNRD1 protein19303893
C025462sulindac sulfidesulindac sulfide results in increased expression of TXNRD1 mRNA16184548
C074269Sunphenon"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of TXNRD1 mRNA"24378064
D013481SuperoxidesAuranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481SuperoxidesDinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481SuperoxidesDithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481Superoxidesformic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481Superoxidesmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481SuperoxidesOxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481SuperoxidesPentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481SuperoxidesSodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481Superoxides[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]20457604
D013481Superoxides[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides20457604
C446685systhanesysthane affects the expression of TXNRD1 mRNA17383973
D014284TriiodothyronineTriiodothyronine results in decreased expression of TXNRD1 mRNA19228888
D013629Tamoxifen[IFNB1 protein co-treated with Tamoxifen] results in increased expression of TXNRD1 protein10771088
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to TXNRD1 protein]23665804
D013629TamoxifenTamoxifen affects the expression of TXNRD1 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of TXNRD1 mRNA19224547
C003377taxifolintaxifolin results in increased expression of TXNRD1 mRNA17541156
C003377taxifolintaxifolin results in decreased activity of TXNRD1 protein modified form16618767
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TXNRD1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TXNRD1 mRNA12377990|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TXNRD1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of TXNRD1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TXNRD1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of TXNRD1 mRNA]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TXNRD1 mRNA15034205|1696003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TXNRD1 mRNA16054898|1696003
D013752TetracyclineTetracycline affects the expression of TXNRD1 mRNA25064622
D013752TetracyclineTetracycline results in decreased expression of TXNRD1 mRNA17522070
D013752TetracyclineTetracycline results in increased expression of TXNRD1 mRNA19224547
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of TXNRD1 mRNA12949356
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of TXNRD1 mRNA25613284
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of TXNRD1 mRNA19323979
D013793ThalliumThallium affects the expression of TXNRD1 protein28866748
D013853ThioacetamideThioacetamide affects the expression of TXNRD1 mRNA25064622
D013853ThioacetamideThioacetamide results in increased activity of TXNRD1 protein18215477
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TXNRD1 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of TXNRD1 mRNA16337175|2341159
D008063Thioctic AcidTXNRD1 protein results in increased reduction of Thioctic Acid21172426
D008063Thioctic AcidThioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D013893ThiramThiram results in increased expression of TXNRD1 mRNA24211530
D013893ThiramThiram results in increased expression of TXNRD1 mRNA23445166
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TXNRD1 mRNA22363418|2740439
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of TXNRD1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TXNRD1 mRNA20133372
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution co-treated with 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one] results in increased expression of TXNRD1 mRNA28790194
C032910triadimefontriadimefon affects the expression of TXNRD1 mRNA17383973
D014241TrichloroethyleneTrichloroethylene results in increased expression of TXNRD1 mRNA19448997
C016798triphenylphosphine gold chloridetriphenylphosphine gold chloride results in decreased activity of TXNRD1 protein16510263
C050414tripterinetripterine results in increased expression of TXNRD1 mRNA17010675
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of TXNRD1 mRNA23052192
C022884undecaneundecane results in decreased expression of TXNRD1 protein17337753
D014494UnithiolUnithiol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]20810785
D017974Uranium CompoundsUranium Compounds results in increased expression of TXNRD1 mRNA19654044
C005460uranyl acetatesodium bisulfide inhibits the reaction [uranyl acetate results in decreased expression of TXNRD1 protein]26523793
C005460uranyl acetateuranyl acetate results in decreased expression of TXNRD1 protein26523793
C406224valdecoxibvaldecoxib results in increased expression of TXNRD1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TXNRD1 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of TXNRD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TXNRD1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of TXNRD1 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of TXNRD1 mRNA17381134
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TXNRD1 gene25560391
D024483Vitamin K 3Vitamin K 3 results in increased expression of TXNRD1 mRNA12414654
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of TXNRD1 mRNA"23246600
D019820Xanthine[Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]16618767
D015016Yohimbine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA28843594
D015032ZincZinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]16774913
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of TXNRD1 mRNA16357179
D015034Zinc OxideZinc Oxide results in increased expression of TXNRD1 mRNA19755143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004791thioredoxin-disulfide reductase activity-EXP16750198  
GO:0004791thioredoxin-disulfide reductase activity-IBA21873635  
GO:0005515protein binding-IPI15199063  19820694  
GO:0009055electron transfer activity-IEA-  
GO:0015035protein disulfide oxidoreductase activity-IEA-  
GO:0016667oxidoreductase activity, acting on a sulfur group of donors-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0098625methylselenol reductase activity-TAS-  
GO:0098626methylseleninic acid reductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001707mesoderm formation-IEA-  
GO:0001887selenium compound metabolic process-TAS-  
GO:0007165signal transduction-NAS8921404  
GO:0008283cell proliferation-IEA-  
GO:0015949nucleobase-containing small molecule interconversion-TAS-  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0022900electron transport chain-IEA-  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0045454cell redox homeostasis-IBA21873635  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00450Selenocompound metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-1643685DiseaseTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2408522Selenoamino acid metabolismTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408550Metabolism of ingested H2SeO4 and H2SeO3 into H2SeIEA
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS
R-HSA-5263617Metabolism of ingested MeSeO2H into MeSeHTAS
R-HSA-5336415Uptake and function of diphtheria toxinTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27706680Association between TXNRD1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a prospective study. (2016 Sep 2)Ji GYGenet Mol Res
25524402Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)Reszka EJ Trace Elem Med Biol