Gene: SHISA9

729993
CKAMP44
shisa family member 9
protein-coding
16p13.12
Ensembl:ENSG00000237515 MIM:613346 Vega:OTTHUMG00000154258 UniprotKB:B4DS77
NC_000016.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.359e-1 (AD)  6.926e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs734826chr16:13396523 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1501304chr16:13050831 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AJAP10.948
GABRB30.944
GRIA10.941
MYT1L0.94
FRRS1L0.938
ST8SIA30.937
CACNA1E0.935
WSCD20.935
EFNB30.935
SCN3B0.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.572
HEY2-0.557
MYL3-0.545
RAB13-0.538
SNHG18-0.533
ROM1-0.531
CHST14-0.525
YES1-0.524
CSAG1-0.521
RNF135-0.518

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHISA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHISA9 mRNA"27188386
D001151ArsenicArsenic affects the methylation of SHISA9 gene25304211
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SHISA9 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of SHISA9 mRNA27594783
C412815GW 4064GW 4064 results in decreased expression of SHISA9 mRNA26655953
C544151jinfukangjinfukang results in decreased expression of SHISA9 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SHISA9 mRNA28001369
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SHISA9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SHISA9 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of SHISA9 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SHISA9 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SHISA9 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of SHISA9 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SHISA9 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SHISA9 mRNA23179753|2519280

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030165PDZ domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0048172regulation of short-term neuronal synaptic plasticity-IBA21873635  
GO:0048172regulation of short-term neuronal synaptic plasticity-ISS-  
GO:2000311regulation of AMPA receptor activity-IBA21873635  
GO:2000311regulation of AMPA receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008328ionotropic glutamate receptor complex-ISS-  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0032281AMPA glutamate receptor complex-IBA21873635  
GO:0032591dendritic spine membrane-IBA21873635  
GO:0032591dendritic spine membrane-ISS-  
GO:0045202synapse-IBA21873635  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal