Gene: LDLRAD4

753
C18orf1
low density lipoprotein receptor class A domain containing 4
protein-coding
18p11.21
Ensembl:ENSG00000168675 MIM:606571 Vega:OTTHUMG00000181925 UniprotKB:O15165
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.254e-1 (AD)  8.485e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4797793chr18:13638963 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTPBP10.899
NKAIN20.896
KIAA1324L0.89
HBS1L0.887
GNAI10.875
TMEFF10.868
SLC22A150.862
NIPAL30.859
STRN0.858
DIXDC10.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EVC2-0.478
FOXJ1-0.424
CASP7-0.424
SYPL2-0.417
INHBB-0.416
OR4F29-0.416
SIX5-0.408
ZIC2-0.4
OR4F5-0.4
RNF135-0.396

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of LDLRAD4 mRNA"28903501
D000082AcetaminophenAcetaminophen results in decreased expression of LDLRAD4 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of LDLRAD4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LDLRAD4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LDLRAD4 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of LDLRAD4 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LDLRAD4 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LDLRAD4 mRNA19770486
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LDLRAD4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of LDLRAD4 mRNA19619570
C004541biochanin Abiochanin A results in decreased expression of LDLRAD4 mRNA12111696
C006780bisphenol Abisphenol A results in increased expression of LDLRAD4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LDLRAD4 gene28505145
D002994ClofibrateClofibrate results in decreased expression of LDLRAD4 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of LDLRAD4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of LDLRAD4 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of LDLRAD4 promoter27989131
D003703DemecolcineDemecolcine results in increased expression of LDLRAD4 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LDLRAD4 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of LDLRAD4 mRNA25047013
C024565ethylene dichlorideethylene dichloride results in decreased expression of LDLRAD4 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LDLRAD4 mRNA23649840
D005485FlutamideFlutamide results in increased expression of LDLRAD4 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of LDLRAD4 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LDLRAD4 mRNA25613284
C008261lead acetatelead acetate results in increased expression of LDLRAD4 mRNA22609695
C045463leflunomideleflunomide results in increased expression of LDLRAD4 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LDLRAD4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LDLRAD4 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LDLRAD4 mRNA24810058
C046012pentanalpentanal results in increased expression of LDLRAD4 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LDLRAD4 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of LDLRAD4 mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in increased expression of LDLRAD4 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of LDLRAD4 mRNA17404688
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA19059307
C089730rosiglitazonerosiglitazone results in increased expression of LDLRAD4 mRNA16982809
D012643SeleniumSelenium results in increased expression of LDLRAD4 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LDLRAD4 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of LDLRAD4 gene28589171
D013629TamoxifenTamoxifen affects the expression of LDLRAD4 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA19059307
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of LDLRAD4 mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LDLRAD4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LDLRAD4 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LDLRAD4 mRNA21632981
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LDLRAD4 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of LDLRAD4 mRNA23724009
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LDLRAD4 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of LDLRAD4 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of LDLRAD4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LDLRAD4 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of LDLRAD4 mRNA23179753|2718838
D014750VincristineVincristine results in increased expression of LDLRAD4 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0070412R-SMAD binding-IPI24627487  
GO ID GO Term Qualifier Evidence PubMed
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP24627487  
GO:0010991negative regulation of SMAD protein complex assembly-IDA24627487  
GO:0030336negative regulation of cell migration-IMP24627487  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IMP24627487  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IMP24627487  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0016021integral component of membrane-NAS9479497  
GO:0031901early endosome membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal