Gene info: ID 7706

Gene: TRIM25

GENE ID: 7706

Synonyms: EFP|RNF147|Z147|ZNF147

Description: tripartite motif containing 25

Gene type: protein-coding

Location: 17q22

dbXrefs: Ensembl:ENSG00000121060 MIM:600453 Vega:OTTHUMG00000178124 UniprotKB:Q14258

RefSeq: NC_000017.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.828e-1 (AD) 4.176e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2525994	chr17:56899561 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNFX1	0.837
PATL1	0.822
TAP2	0.82
EIF2AK2	0.81
PML	0.792
TRIM14	0.786
STAT2	0.767
WARS	0.765
ZFYVE26	0.765
NUP98	0.762

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.443
OR4F29	-0.412
KLRC2	-0.239
C5orf64	-0.228
NANOGNB	-0.223
SNX22	-0.217
CTNNA3	-0.193
PDE11A	-0.192
REN	-0.191
TMEM114	-0.189

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TRIM25 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TRIM25 mRNA"	21346803
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of TRIM25 mRNA"	27567155
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of TRIM25 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of TRIM25 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of TRIM25 mRNA	17562736
D000086	Acetazolamide	Acetazolamide results in increased expression of TRIM25 mRNA	19274763
D020106	Acrylamide	Acrylamide affects the expression of TRIM25 mRNA	28959563
C016601	afimoxifene	afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]	19148513
C016601	afimoxifene	afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]	19148513
C016601	afimoxifene	afimoxifene results in increased expression of TRIM25 mRNA	19148513
C016601	afimoxifene	afimoxifene results in increased expression of TRIM25 protein	19148513
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TRIM25 mRNA	19770486
C006632	arsenic trioxide	arsenic trioxide results in increased expression of TRIM25 protein	25419056
D004958	Estradiol	afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]	19148513
D004958	Estradiol	afimoxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]	19148513
D004958	Estradiol	Estradiol results in increased expression of TRIM25 mRNA	19148513\|2301914
D004958	Estradiol	Estradiol results in increased expression of TRIM25 protein	19148513
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]	19148513
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]	19148513
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of TRIM25 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of TRIM25 mRNA	21932408
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of TRIM25 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of TRIM25 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of TRIM25 mRNA	14729362\|1500399
C584509	C646 compound	C646 compound results in increased expression of TRIM25 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of TRIM25 protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of TRIM25 mRNA	23741332
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TRIM25 mRNA	19320972
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIM25 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of TRIM25 mRNA	19770486
D003907	Dexamethasone	Dexamethasone results in increased expression of TRIM25 mRNA	21041162
C118739	entinostat	entinostat results in increased expression of TRIM25 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of TRIM25 mRNA	20064776
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TRIM25 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of TRIM25 mRNA	17557909
D005485	Flutamide	Flutamide results in decreased expression of TRIM25 mRNA	24136188\|2479361
C039281	furan	furan results in increased expression of TRIM25 mRNA	26194646
D019833	Genistein	Genistein results in increased expression of TRIM25 mRNA	23019147
D005839	Gentamicins	Gentamicins results in increased expression of TRIM25 mRNA	22061828
D017313	Fenretinide	Fenretinide results in increased expression of TRIM25 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of TRIM25 mRNA	14729362
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRIM25 mRNA	25613284
C045463	leflunomide	leflunomide results in decreased expression of TRIM25 mRNA	28988120
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TRIM25 mRNA	23103053
D008774	Methylphenidate	Methylphenidate results in increased expression of TRIM25 mRNA	22470460
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of TRIM25 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TRIM25 mRNA"	25554681
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of TRIM25 mRNA	23892564
D010634	Phenobarbital	Phenobarbital affects the expression of TRIM25 mRNA	19159669
D010656	Phenylephrine	Phenylephrine results in decreased expression of TRIM25 mRNA	18158353
C045950	propiconazole	propiconazole results in decreased expression of TRIM25 mRNA	21278054
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of TRIM25 mRNA	27029645
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]	19148513
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]	19148513
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of TRIM25 protein	28918527
D018038	Sodium Selenite	Sodium Selenite results in increased expression of TRIM25 mRNA	24383545
D012999	Soman	Soman results in increased expression of TRIM25 mRNA	19281266
C061133	tamibarotene	tamibarotene affects the expression of TRIM25 mRNA	15498508
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TRIM25 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRIM25 mRNA	25613284
D014212	Tretinoin	Tretinoin results in decreased expression of TRIM25 mRNA	15498508
D014212	Tretinoin	Tretinoin results in decreased expression of TRIM25 mRNA	16604517
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of TRIM25 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM25 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of TRIM25 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of TRIM25 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of TRIM25 mRNA	24896083
C025643	vinclozolin	vinclozolin results in decreased expression of TRIM25 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003700	DNA-binding transcription factor activity	-	TAS	8248217
GO:0003723	RNA binding	-	HDA	22658674
GO:0004842	ubiquitin-protein transferase activity	-	EXP	17392790 19017631 19484123
GO:0005515	protein binding	-	IPI	19454348 20818395 22452784 24478431
GO:0008270	zinc ion binding	-	IEA	-
GO:0016874	ligase activity	-	IEA	-
GO:0045296	cadherin binding	-	HDA	25468996
GO:0061630	ubiquitin protein ligase activity	-	IMP	24810856

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006511	ubiquitin-dependent protein catabolic process	-	IMP	22452784 24810856
GO:0006513	protein monoubiquitination	-	IMP	24810856
GO:0016032	viral process	-	IEA	-
GO:0019985	translesion synthesis	-	TAS	-
GO:0030433	ubiquitin-dependent ERAD pathway	-	IMP	24810856
GO:0032480	negative regulation of type I interferon production	-	TAS	-
GO:0033280	response to vitamin D	-	IEA	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	23077300
GO:0043627	response to estrogen	-	IDA	22452784
GO:0045087	innate immune response	-	IDA	18248090
GO:0045087	innate immune response	-	TAS	-
GO:0046596	regulation of viral entry into host cell	-	IDA	18248090
GO:0046597	negative regulation of viral entry into host cell	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IMP	23077300
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	23077300
GO:0051607	defense response to virus	-	IEA	-
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:1902186	regulation of viral release from host cell	-	IMP	18248090
GO:1902187	negative regulation of viral release from host cell	-	IEA	-
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0016604	nuclear body	-	IDA	-

KEGG ID	KEGG Term
hsa04622	RIG-I-like receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-913531	Interferon Signaling	TAS
R-HSA-918233	TRAF3-dependent IRF activation pathway	TAS
R-HSA-933541	TRAF6 mediated IRF7 activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	IEA
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	TAS
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal