Gene: ZNF236

7776
ZNF236A|ZNF236B
zinc finger protein 236
protein-coding
18q23
Ensembl:ENSG00000130856 MIM:604760 Vega:OTTHUMG00000179331 UniprotKB:Q9UL36
NC_000018.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.757e-1 (AD)  9.833e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs562832chr18:76915143 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASH1L0.931
HECTD40.916
NF10.912
RALGPS10.908
MECP20.9
ZNF8270.898
RALGAPB0.895
URB10.894
SBNO10.892
HERC20.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.46
CSAG1-0.427
OR4F29-0.417
RAB13-0.398
PRRX2-0.389
ROM1-0.376
COPZ2-0.356
SNHG18-0.353
PDZK1IP1-0.352
MYL3-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF236 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF236 mRNA"27188386
D001151ArsenicArsenic affects the methylation of ZNF236 gene25304211
C006780bisphenol Abisphenol A results in decreased expression of ZNF236 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF236 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of ZNF236 mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of ZNF236 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of ZNF236 mRNA22077320
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ZNF236 mRNA]27941970
D004026DieldrinDieldrin results in increased expression of ZNF236 mRNA28385952
D005557FormaldehydeFormaldehyde results in decreased expression of ZNF236 mRNA23416264
D017313FenretinideFenretinide results in increased expression of ZNF236 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ZNF236 mRNA18951874
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNF236 mRNA28001369
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF236 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ZNF236 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased methylation of ZNF236 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0071333cellular response to glucose stimulus-IEP9299475  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21618603Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. (2011 Sep)Beaty THGenet Epidemiol