Gene: EVI5

7813
EVI-5|NB4S
ecotropic viral integration site 5
protein-coding
1p22.1
Ensembl:ENSG00000067208 MIM:602942 Vega:OTTHUMG00000010895 UniprotKB:O60447
NC_000001.11
SNP Mapped
8   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.005e-1 (AD)  4.926e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1556562chr1:92568466 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4847377chr1:92557593 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6603981chr1:92528250 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4970712chr1:92527990 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1408916chr1:92527070 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6603979chr1:92513797 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1886682chr1:92511718 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10782922chr1:92509038 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITCH0.886
IBTK0.861
ARID4B0.859
FAM208A0.851
GPATCH2L0.848
PRPF4B0.847
FAR10.847
UBA60.845
ANKRD280.844
SESTD10.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.525
OR4F5-0.519
PLA2G5-0.345
WNT7B-0.291
EYA2-0.263
HES5-0.26
PPP1R3G-0.258
BANF2-0.257
LYPD1-0.245
SLC7A10-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of EVI5 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of EVI5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EVI5 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of EVI5 mRNA21298039
D001151ArsenicArsenic affects the methylation of EVI5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EVI5 mRNA20064835|2010694
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of EVI5 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EVI5 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EVI5 mRNA22228805
C006780bisphenol Abisphenol A results in decreased methylation of EVI5 promoter27312807
C584509C646 compoundC646 compound results in increased expression of EVI5 mRNA26191083
D005576ColforsinColforsin results in increased expression of EVI5 mRNA16751804
D019327Copper SulfateCopper Sulfate results in increased expression of EVI5 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of EVI5 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of EVI5 mRNA22077320
D002945CisplatinCisplatin results in decreased expression of EVI5 mRNA27594783
D002117CalcitriolCalcitriol results in increased expression of EVI5 mRNA16002434
C001277geldanamycingeldanamycin results in increased expression of EVI5 mRNA26705709
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA19695318
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EVI5 mRNA21179406
C544151jinfukangjinfukang results in decreased expression of EVI5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EVI5 mRNA24796395
C410337K 7174K 7174 results in increased expression of EVI5 mRNA24086573
D007854LeadEVI5 gene mutant form results in increased susceptibility to [lead acetate results in increased abundance of Lead]26859824
D007854LeadEVI5 gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
C008261lead acetateEVI5 gene mutant form results in increased susceptibility to [lead acetate results in increased abundance of Lead]26859824
C008261lead acetateEVI5 gene SNP affects the susceptibility to [lead acetate results in increased abundance of Lead]26859824
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EVI5 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of EVI5 mRNA27188386
D008727MethotrexateMethotrexate results in increased expression of EVI5 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EVI5 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of EVI5 promoter"26251327
D015741MetriboloneMetribolone results in increased expression of EVI5 mRNA16751804
D008942MitoxantroneEVI5 protein affects the susceptibility to Mitoxantrone16217747
C568376MT19c compoundMT19c compound results in increased expression of EVI5 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EVI5 mRNA"25554681
C018620oleoresinsoleoresins results in decreased expression of EVI5 mRNA20008804
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EVI5 mRNA25729387
C016030pantogabpantogab results in decreased expression of EVI5 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of EVI5 mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of EVI5 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of EVI5 mRNA18445702
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA19695318
C045950propiconazolepropiconazole results in decreased expression of EVI5 mRNA21278054
D012643SeleniumSelenium results in decreased expression of EVI5 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of EVI5 mRNA19073995|2322117
C009277sodium arsenatesodium arsenate results in decreased expression of EVI5 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of EVI5 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EVI5 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EVI5 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of EVI5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EVI5 mRNA15034205
D013849ThimerosalThimerosal results in decreased expression of EVI5 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EVI5 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EVI5 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of EVI5 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EVI5 mRNA24935251|2627250
D014501UraniumUranium affects the expression of EVI5 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of EVI5 mRNA15672453
D014520UrethaneUrethane results in increased expression of EVI5 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of EVI5 mRNA24935251
D014810Vitamin EVitamin E results in decreased expression of EVI5 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of EVI5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA17562788  
GO:0005515protein binding-IPI16439210  17229837  26496610  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0017137Rab GTPase binding-IPI17562788  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0007275multicellular organism development-TAS9618176  
GO:0008283cell proliferation-TAS9618176  
GO:0042147retrograde transport, endosome to Golgi-IMP17562788  
GO:0043547positive regulation of GTPase activity-IDA17562788  
GO:0051301cell division-IEA-  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005819spindle-IEA-  
GO:0005829cytosol-IDA17562788  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal