Gene: NOX5

79400
-
NADPH oxidase 5
protein-coding
15q23
Ensembl:ENSG00000255346 MIM:606572 Vega:OTTHUMG00000133320 UniprotKB:Q96PH1
NG_030464.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.140e-1 (AD)  4.909e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4777102chr15:68986207 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4365239chr15:68952341 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM660.585
ANKRD36C0.58
ARMC20.577
MYO190.562
SH3D210.561
FER1L50.56
DNAH10.559
KLHL100.559
WNT10.558
OGFOD20.554

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VAX2-0.33
MTRNR2L9-0.328
MYL3-0.308
MTRNR2L6-0.304
MTRNR2L10-0.291
AQP5-0.276
MTRNR2L8-0.272
NR0B1-0.265
ZNF114-0.265
FOXJ1-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NOX5 mRNA"25305463
D000109AcetylcholineNOX5 protein affects the susceptibility to Acetylcholine18556569
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NOX5 mRNA21298039
C530884anacetrapibanacetrapib results in decreased expression of NOX5 protein25617244
D004958EstradiolEstradiol results in decreased expression of NOX5 mRNA23373633
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of NOX5 protein21742780
D003300CopperCopper results in increased expression of NOX5 mRNA18522721
C411602dalcetrapibdalcetrapib results in increased expression of NOX5 protein25617244
D007529IsoflavonesIsoflavones affects the expression of NOX5 mRNA16365062
D009569Nitric OxideNOX5 protein promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]18556569
D009569Nitric OxideNOX5 protein promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]18556569
D009585Nitrogen DioxideNitrogen Dioxide results in decreased expression of NOX5 mRNA27206323
D010656PhenylephrineNOX5 protein affects the susceptibility to Phenylephrine18556569
C017947sodium arsenitesodium arsenite results in increased expression of NOX5 mRNA28229933
D013481SuperoxidesNOX5 protein results in increased abundance of Superoxides18556569
C483909torcetrapibtorcetrapib results in increased expression of NOX5 mRNA25617244
C483909torcetrapibtorcetrapib results in increased expression of NOX5 protein25617244
D014635Valproic AcidValproic Acid results in increased methylation of NOX5 gene29154799
D014638VanadatesVanadates results in decreased expression of NOX5 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0015252proton channel activity-IDA11483596  
GO:0016175superoxide-generating NADPH oxidase activity-IDA11483596  
GO:0016175superoxide-generating NADPH oxidase activity-TAS-  
GO:0020037heme binding-NAS11483596  
GO:0050660flavin adenine dinucleotide binding-NAS11483596  
GO:0050661NADP binding-NAS11483596  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001935endothelial cell proliferation-IDA17275676  
GO:0006915apoptotic process-NAS11483596  
GO:0008283cell proliferation-NAS11483596  
GO:0010155regulation of proton transport-NAS11483596  
GO:0034599cellular response to oxidative stress-TAS-  
GO:0042554superoxide anion generation-IDA11483596  
GO:0043012regulation of fusion of sperm to egg plasma membrane-NAS11483596  
GO:0050663cytokine secretion-NAS11483596  
GO:0055114oxidation-reduction process-IDA11483596  
GO:0061640cytoskeleton-dependent cytokinesis-NAS11483596  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24180474NADPH oxidases in vascular pathology. (2014 Jun 10)Konior AAntioxid Redox Signal
23506637Mechanisms of oxidative stress in human aortic aneurysms--association with clinical risk factors for atherosclerosis and disease severity. (2013 Oct 3)Guzik BInt J Cardiol
23143793Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium. (2013 Feb)Rius CThorax
29326688Cigarette Smoke Increases Endothelial CXCL16-Leukocyte CXCR6 Adhesion In Vitro and In Vivo. Potential Consequences in Chronic Obstructive Pulmonary Disease. (2017)Marques PFront Immunol