Gene: SPAG16

79582
PF20|WDR29
sperm associated antigen 16
protein-coding
2q34
Ensembl:ENSG00000144451 MIM:612173 Vega:OTTHUMG00000133015 UniprotKB:Q8N0X2
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.172e-1 (AD)  2.273e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7597928chr2:213727658 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RMDN10.83
IFT880.828
FAM177A10.822
LRRCC10.817
NUDCD20.805
FAM229B0.805
ZCRB10.805
PRTFDC10.797
SNX60.793
GCSH0.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPRD1-0.413
OR4F29-0.413
SCRT2-0.404
EPPIN-0.394
KCNK12-0.385
TCERG1L-0.384
CHRNA2-0.383
BEAN1-0.365
HIVEP3-0.36
FAM160A1-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of SPAG16 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SPAG16 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SPAG16 mRNA24449571
C015001arsenitearsenite results in increased methylation of SPAG16 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of SPAG16 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPAG16 mRNA27195522
D004958EstradiolEstradiol affects the expression of SPAG16 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of SPAG16 mRNA23019147
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of SPAG16 mRNA25270620
C006780bisphenol Abisphenol A results in decreased expression of SPAG16 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SPAG16 gene28505145
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SPAG16 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SPAG16 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of SPAG16 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SPAG16 mRNA25562108
D003561CytarabineCytarabine results in increased expression of SPAG16 mRNA21198554
D002945CisplatinCisplatin results in decreased expression of SPAG16 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of SPAG16 mRNA28302478
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SPAG16 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SPAG16 mRNA26033743
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPAG16 mRNA22079256
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of SPAG16 mRNA20846436
D019833GenisteinGenistein results in decreased expression of SPAG16 mRNA23019147
C028473N-acetyl-4-benzoquinoneimineSPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SPAG16 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SPAG16 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of SPAG16 mRNA19159669
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPAG16 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SPAG16 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of SPAG16 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SPAG16 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPAG16 mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of SPAG16 mRNA23557971
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SPAG16 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007288sperm axoneme assembly-IEA-  
GO:0035082axoneme assembly-IBA21873635  
GO:0035082axoneme assembly-IMP17699735  
GO:0051012microtubule sliding-IEA-  
GO:0060271cilium assembly-ISS-  
GO:0060294cilium movement involved in cell motility-IEA-  
GO:0097231cell motility in response to calcium ion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005930axoneme-ISS-  
GO:0031514motile cilium-IEA-  
GO:1990716axonemal central apparatus-IBA21873635  
GO:1990716axonemal central apparatus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal