Gene: ADIPOR2

79602
ACDCR2|PAQR2
adiponectin receptor 2
protein-coding
12p13.33
Ensembl:ENSG00000006831 MIM:607946 Vega:OTTHUMG00000130139 UniprotKB:Q86V24
NC_000012.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.575e-1 (AD)  3.875e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10161408chr12:1779507 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDRG10.904
USP540.899
PIP4K2A0.899
CLDND10.885
SLAIN10.865
VEZF10.864
GLTP0.864
RTKN0.862
CERS20.861
ZNF6520.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.503
OR4F5-0.441
FBLN7-0.411
PTHLH-0.408
CHRNA2-0.407
VIP-0.405
IGF1-0.404
CUX2-0.402
HAPLN1-0.394
DLX1-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ADIPOR2 mRNA"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR2 protein"28284726
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADIPOR2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADIPOR2 mRNA"20959002
D000079AcetaldehydeAcetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein]17949463
D000079AcetaldehydeAcetaldehyde results in increased expression of ADIPOR2 protein17949463
D000082AcetaminophenAcetaminophen affects the expression of ADIPOR2 mRNA25064622
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]21912612
D000111AcetylcysteineAllopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]]21912612
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADIPOR2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ADIPOR2 gene27153756
D000493AllopurinolAllopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]]21912612
D000638AmiodaroneAmiodarone affects the expression of ADIPOR2 mRNA25064622
D001151ArsenicArsenic affects the methylation of ADIPOR2 gene25304211
D001280AtrazineAtrazine results in increased expression of ADIPOR2 mRNA25929836
D006051Aurothioglucose[Dietary Fats co-treated with Aurothioglucose] results in decreased expression of ADIPOR2 protein21382165
C547126AZM551248AZM551248 results in decreased expression of ADIPOR2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADIPOR2 mRNA23735875
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADIPOR2 mRNA21964900
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADIPOR2 protein28284726
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADIPOR2 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADIPOR2 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ADIPOR2 mRNA19619570|2118537
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ADIPOR2 mRNA17404688
D004958EstradiolEstradiol results in increased expression of ADIPOR2 protein28284726
D001629BezafibrateBezafibrate results in increased expression of ADIPOR2 mRNA16574099
C006780bisphenol Abisphenol A results in decreased methylation of ADIPOR2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ADIPOR2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ADIPOR2 mRNA28657538
C006780bisphenol Abisphenol A results in decreased expression of ADIPOR2 protein24472609
C006780bisphenol Abisphenol A results in increased expression of ADIPOR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ADIPOR2 protein28284726
D002065BuspironeBuspirone results in decreased expression of ADIPOR2 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ADIPOR2 mRNA15336504
D002110CaffeineCaffeine results in increased expression of ADIPOR2 mRNA22583948
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ADIPOR2 mRNA24763279
D002746ChlorpromazineChlorpromazine affects the expression of ADIPOR2 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADIPOR2 mRNA20938992
C503589cis-9, trans-11-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR2 mRNA"17408517
D019327Copper SulfateCopper Sulfate results in increased expression of ADIPOR2 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of ADIPOR2 mRNA25064622
D003907DexamethasoneDexamethasone promotes the reaction [rosiglitazone results in increased activity of ADIPOR2 promoter]16609881
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADIPOR2 mRNA23428407
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADIPOR2 mRNA21266533
D004041Dietary Fats[Dietary Fats co-treated with Aurothioglucose] results in decreased expression of ADIPOR2 protein21382165
D004041Dietary FatsDietary Fats results in decreased expression of ADIPOR2 mRNA18042831
D004041Dietary FatsDietary Fats affects the expression of ADIPOR2 mRNA20965162
D004041Dietary FatsDietary Fats affects the expression of ADIPOR2 protein20965162
D004041Dietary Fatsrosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR2 mRNA]20965162
D004041Dietary Fatsrosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR2 protein]20965162
D004147DioxinsDioxins affects the expression of ADIPOR2 mRNA20463971
D004237DiuronDiuron results in decreased expression of ADIPOR2 mRNA25152437
C012301domoic aciddomoic acid results in increased expression of ADIPOR2 mRNA18936300
D000431EthanolEthanol results in decreased expression of ADIPOR2 mRNA18755807|2000785
D000431Ethanol[rosiglitazone co-treated with Ethanol] results in increased expression of ADIPOR2 mRNA20007851
D000431EthanolEthanol results in decreased expression of ADIPOR2 mRNA26115886
D000431EthanolEthanol results in decreased expression of ADIPOR2 protein26115886
D000431EthanolScopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]26115886
D000431EthanolScopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]26115886
D000431EthanolSilymarin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]26115886
D000431EthanolSilymarin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]26115886
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ADIPOR2 mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADIPOR2 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of ADIPOR2 mRNA28189721
D011345FenofibrateFenofibrate results in increased expression of ADIPOR2 mRNA16306350
D018120FinasterideFinasteride results in increased expression of ADIPOR2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADIPOR2 mRNA20938992
D005632FructoseFructose results in decreased expression of ADIPOR2 protein28257781
D005897GlafenineGlafenine results in decreased expression of ADIPOR2 mRNA24136188
D005947GlucoseADIPOQ protein inhibits the reaction [Glucose results in decreased expression of ADIPOR2 protein]21912612
D005947GlucoseGlucose results in decreased expression of ADIPOR2 protein21912612
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA19695318
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ADIPOR2 mRNA24763279
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of ADIPOR2 protein28284726
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADIPOR2 mRNA23428407
D007529IsoflavonesIsoflavones results in decreased expression of ADIPOR2 protein22155228
C008261lead acetatelead acetate results in increased expression of ADIPOR2 mRNA21829687
C045463leflunomideleflunomide results in decreased expression of ADIPOR2 mRNA28988120
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in decreased expression of ADIPOR2 mRNA"17322064
D044243Linoleic Acids, Conjugated"rosiglitazone inhibits the reaction [Linoleic Acids, Conjugated results in decreased expression of ADIPOR2 mRNA]"17322064
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADIPOR2 mRNA"20371263
D008070LipopolysaccharidesADIPOR2 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]20861358
D008070LipopolysaccharidesADIPOR2 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]20861358
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADIPOR2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of ADIPOR2 mRNA17400583
C005219methyl cellosolvemethyl cellosolve results in increased expression of ADIPOR2 mRNA21061450
D015735MifepristoneMifepristone inhibits the reaction [rosiglitazone results in increased activity of ADIPOR2 promoter]16609881
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ADIPOR2 mRNA"29244179
C028007nickel monoxidenickel monoxide results in increased expression of ADIPOR2 mRNA19167457
D009538NicotineNicotine results in increased expression of ADIPOR2 mRNA22265867
C012655nimesulidenimesulide results in decreased expression of ADIPOR2 mRNA24136188
C018620oleoresinsoleoresins results in decreased expression of ADIPOR2 mRNA20008804
D000073878Palm OilPalm Oil results in decreased expression of ADIPOR2 mRNA18042831
D010269ParaquatParaquat affects the expression of ADIPOR2 mRNA25064622
D010269ParaquatADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 mRNA]25945502
D010269ParaquatADIPOR1 protein inhibits the reaction [Paraquat results in increased expression of ADIPOR2 protein]25945502
D010269ParaquatParaquat results in increased expression of ADIPOR2 mRNA25945502
D010269ParaquatParaquat results in increased expression of ADIPOR2 protein25945502
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ADIPOR2 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADIPOR2 mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADIPOR2 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADIPOR2 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADIPOR2 mRNA19162173
D010575PesticidesPesticides results in decreased methylation of ADIPOR2 gene28396702
D010795Phthalic AcidsPhthalic Acids results in increased expression of ADIPOR2 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ADIPOR2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ADIPOR2 mRNA16306350|1830175
C006253pirinixic acidpirinixic acid results in increased expression of ADIPOR2 mRNA19162173
D010894PiroxicamPiroxicam results in decreased expression of ADIPOR2 mRNA21858171
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA19695318
D011374ProgesteroneProgesterone results in increased expression of ADIPOR2 mRNA23018184
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ADIPOR2 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of ADIPOR2 mRNA17404688
C045950propiconazolepropiconazole results in decreased expression of ADIPOR2 mRNA21278054
C059514resveratrolresveratrol results in increased expression of ADIPOR2 mRNA18755807
C089730rosiglitazoneDexamethasone promotes the reaction [rosiglitazone results in increased activity of ADIPOR2 promoter]16609881
C089730rosiglitazoneMifepristone inhibits the reaction [rosiglitazone results in increased activity of ADIPOR2 promoter]16609881
C089730rosiglitazonerosiglitazone results in increased activity of ADIPOR2 promoter16609881
C089730rosiglitazonerosiglitazone results in increased expression of ADIPOR2 mRNA16609881
C089730rosiglitazonerosiglitazone results in increased expression of ADIPOR2 protein16609881
C089730rosiglitazone[rosiglitazone co-treated with Ethanol] results in increased expression of ADIPOR2 mRNA20007851
C089730rosiglitazone"rosiglitazone inhibits the reaction [Linoleic Acids, Conjugated results in decreased expression of ADIPOR2 mRNA]"17322064
C089730rosiglitazonerosiglitazone results in increased expression of ADIPOR2 mRNA16306350|1660988
C089730rosiglitazonerosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR2 mRNA]20965162
C089730rosiglitazonerosiglitazone affects the reaction [Dietary Fats affects the expression of ADIPOR2 protein]20965162
D012603ScopoletinScopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]26115886
D012603ScopoletinScopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]26115886
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ADIPOR2 mRNA23221170
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]26115886
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]26115886
D013311StreptozocinAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]21912612
D013311StreptozocinAllopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]]21912612
D013311StreptozocinStreptozocin results in decreased expression of ADIPOR2 protein21912612
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADIPOR2 mRNA"20371263
C501413tesaglitazartesaglitazar results in increased expression of ADIPOR2 mRNA21515302
D013739TestosteroneTestosterone results in decreased expression of ADIPOR2 protein28284726
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADIPOR2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADIPOR2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADIPOR2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADIPOR2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADIPOR2 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADIPOR2 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADIPOR2 mRNA26232522
D013752TetracyclineTetracycline affects the expression of ADIPOR2 mRNA25064622
D013752TetracyclineTetracycline results in increased expression of ADIPOR2 mRNA16917069
D013853ThioacetamideThioacetamide affects the expression of ADIPOR2 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of ADIPOR2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ADIPOR2 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ADIPOR2 mRNA18087596
C496197trans-10,cis-12-conjugated linoleic acid"[trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR2 mRNA"17408517
C011559tributyltintributyltin results in increased expression of ADIPOR2 mRNA23428407
C012589trichostatin Atrichostatin A affects the expression of ADIPOR2 mRNA28542535
C080163trovafloxacintrovafloxacin results in decreased expression of ADIPOR2 mRNA24136188
D014520UrethaneUrethane results in increased expression of ADIPOR2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of ADIPOR2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of ADIPOR2 mRNA25064622
C025643vinclozolinvinclozolin results in increased expression of ADIPOR2 mRNA23869203
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ADIPOR2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042802identical protein binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0055100adiponectin binding-IDA12802337  
GO:0097003adipokinetic hormone receptor activity-IDA12802337  
GO ID GO Term Qualifier Evidence PubMed
GO:0007507heart development-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0009755hormone-mediated signaling pathway-ISS12802337  
GO:0019395fatty acid oxidation-ISS12802337  
GO:0030308negative regulation of cell growth-IEA-  
GO:0033211adiponectin-activated signaling pathway-IBA21873635  
GO:0033211adiponectin-activated signaling pathway-IDA12802337  
GO:0042304regulation of fatty acid biosynthetic process-TAS-  
GO:0042593glucose homeostasis-ISS-  
GO:0046326positive regulation of glucose import-IEA-  
GO:0061042vascular wound healing-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-IDA12802337  
KEGG ID KEGG Term
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityTAS
R-HSA-163680AMPK inhibits chREBP transcriptional activation activityIEA
R-HSA-163685Integration of energy metabolismTAS
R-HSA-163685Integration of energy metabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19051043Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. (2009 Jul)Dalamaga MCancer Causes Control
26629210Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke. (2015)Han QInt J Clin Exp Med
18424891Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. (2007)Petridou ETOncology
23358237Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma. (2013 Feb)Abdul-Ghafar JTohoku J Exp Med
25760347Adiponectin in asthma: implications for phenotyping. (2015)Nigro ECurr Protein Pept Sci
22087284Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer. (2011)Liu LPLoS One
25345946[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease]. (2014 Oct)Zhang CNan Fang Yi Ke Da Xue Xue Bao