Gene: ARSJ

79642
ASJ
arylsulfatase family member J
protein-coding
4q26
Ensembl:ENSG00000180801 MIM:610010 Vega:OTTHUMG00000161067 UniprotKB:Q5FYB0
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.720e-1 (AD)  1.767e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10012206chr4:113955964 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26728709chr4:114823338ARSJ9.400e-17Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCSK50.669
DNAJC30.665
UGDH0.655
ZNF8440.647
FBXO300.644
PLOD20.638
CLCF10.636
TXNRD10.634
C2CD4A0.633
ODC10.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BHLHA9-0.281
LTK-0.273
E2F1-0.266
FAM228A-0.256
HRASLS-0.243
C10orf67-0.243
PLD5-0.241
EIF4E1B-0.239
FRAT1-0.238
RHOV-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ARSJ mRNA28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARSJ gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARSJ mRNA22100608
D001151ArsenicArsenic results in increased methylation of ARSJ promoter21291286
D001280AtrazineAtrazine results in decreased expression of ARSJ mRNA22378314
C547126AZM551248AZM551248 results in increased expression of ARSJ mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ARSJ mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ARSJ mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARSJ mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of ARSJ mRNA21185374
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ARSJ mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ARSJ mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ARSJ mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ARSJ mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARSJ gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ARSJ mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of ARSJ mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARSJ mRNA19320972
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of ARSJ mRNA26033743
D003300CopperCopper deficiency results in increased expression of ARSJ mRNA26033743
D003471CuprizoneCuprizone results in increased expression of ARSJ mRNA27523638
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ARSJ mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ARSJ mRNA27392435
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of ARSJ mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of ARSJ mRNA26033743
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARSJ mRNA22079256
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ARSJ mRNA28329830
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ARSJ mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ARSJ mRNA28001369
C523799MRK 003ARSJ results in increased susceptibility to MRK 00319903844
C028007nickel monoxidenickel monoxide results in decreased expression of ARSJ mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ARSJ mRNA"25510870
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARSJ mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARSJ mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARSJ mRNA22079256
D012293RifampinRifampin results in decreased expression of ARSJ mRNA24552687
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARSJ mRNA22298810
D014212TretinoinTretinoin results in decreased expression of ARSJ mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ARSJ mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of ARSJ mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ARSJ mRNA28001369
D014638VanadatesVanadates results in increased expression of ARSJ mRNA22714537
C066075vanadium pentoxidevanadium pentoxide affects the expression of ARSJ mRNA26210822
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARSJ gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004065arylsulfatase activity-TAS16174644  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008152metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-1663150The activation of arylsulfatasesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal