Gene: ARHGAP10

79658
GRAF2|PS-GAP|PSGAP
Rho GTPase activating protein 10
protein-coding
4q31.23
Ensembl:ENSG00000071205 MIM:609746 Vega:OTTHUMG00000161460 UniprotKB:A1A4S6
NC_000004.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.536e-1 (AD)  1.581e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs964170chr4:147774805 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24116965chr4:148654701ARHGAP108.180e-8Maternal smoking in pregnancy27040690
cg24116965chr4:148654701ARHGAP105.330e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO1B0.678
FRZB0.628
SRL0.607
GRK50.595
WTIP0.595
TPM10.593
SLC38A110.558
CLEC10A0.557
OSR10.556
AFAP1L20.555

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM6-0.382
OR4F5-0.377
FXYD4-0.365
OR4F29-0.36
BTBD16-0.347
PDE11A-0.338
TMEM139-0.314
ZFP57-0.31
SMIM5-0.309
CAPN9-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARHGAP10 mRNA19933214
D020106AcrylamideAcrylamide affects the expression of ARHGAP10 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ARHGAP10 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ARHGAP10 gene28458013
D001151ArsenicArsenic affects the methylation of ARHGAP10 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGAP10 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ARHGAP10 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ARHGAP10 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGAP10 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP10 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ARHGAP10 mRNA24386269
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ARHGAP10 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ARHGAP10 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of ARHGAP10 mRNA17998272|2273378
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARHGAP10 mRNA17361019
D002945CisplatinCisplatin results in increased expression of ARHGAP10 mRNA19561079
D004041Dietary FatsDietary Fats results in increased expression of ARHGAP10 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of ARHGAP10 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ARHGAP10 mRNA"22485181
D004221DisulfiramDisulfiram results in decreased expression of ARHGAP10 mRNA20530235
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP10 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP10 mRNA20938992
C069837fullerene C60fullerene C60 affects the expression of ARHGAP10 mRNA19167457
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP10 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP10 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of ARHGAP10 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ARHGAP10 mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of ARHGAP10 mRNA19167457
D009966OrphenadrineOrphenadrine affects the expression of ARHGAP10 mRNA23665939
C006253pirinixic acidpirinixic acid results in increased expression of ARHGAP10 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP10 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARHGAP10 mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ARHGAP10 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARHGAP10 mRNA24780913
D013629TamoxifenTamoxifen results in increased expression of ARHGAP10 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP10 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARHGAP10 mRNA19933214|2629044
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP10 mRNA25613284
D013893ThiramThiram results in decreased expression of ARHGAP10 mRNA20530235
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of ARHGAP10 mRNA16341940
D014810Vitamin EVitamin E results in increased expression of ARHGAP10 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI11432776  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IBA21873635  
GO:0007010cytoskeleton organization-IEA-  
GO:0007165signal transduction-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-169911Regulation of ApoptosisIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-211728Regulation of PAK-2p34 activity by PS-GAP/RHG10IEA
R-HSA-5357801Programmed Cell DeathIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal