Gene: TBL1XR1

79718
C21|DC42|IRA1|MRD41|TBLR1
transducin beta like 1 X-linked receptor 1
protein-coding
3q26.32
Ensembl:ENSG00000177565 MIM:608628 Vega:OTTHUMG00000157140 UniprotKB:Q9BZK7
NG_047195.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.199e-1 (AD)  4.246e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7632766chr3:177150265 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1209035chr3:177110139 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1201284chr3:177089526 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13273540chr3:176850227TBL1XR1Promoter9.724e-5Alcohol use disorders26763658
cg06657944chr3:176915062TBL1XR11.810e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB6A0.954
SPIN10.954
MATR30.952
MARCH60.951
USP330.951
ARL8B0.95
ATP6AP20.95
REEP50.948
RAB2A0.947
NDFIP10.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.697
OR4F29-0.662
CSAG1-0.386
TFPI2-0.338
MTRNR2L10-0.324
CXCR2-0.316
RUNX3-0.315
KCNJ15-0.314
PGF-0.311
CNN2-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TBL1XR1 mRNA"22698814
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TBL1XR1 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TBL1XR1 mRNA12958071
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of TBL1XR1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TBL1XR1 mRNA21420995|2223033
D020106AcrylamideAcrylamide results in decreased expression of TBL1XR1 mRNA28959563
D001151ArsenicArsenic affects the methylation of TBL1XR1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBL1XR1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBL1XR1 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of TBL1XR1 mRNA20068009
C006780bisphenol Abisphenol A affects the expression of TBL1XR1 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of TBL1XR1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TBL1XR1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of TBL1XR1 mRNA23410634
C018475butyraldehydebutyraldehyde results in decreased expression of TBL1XR1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TBL1XR1 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TBL1XR1 mRNA17484886
C099555CD 437CD 437 results in decreased expression of TBL1XR1 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TBL1XR1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of TBL1XR1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TBL1XR1 mRNA18668222
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBL1XR1 mRNA17602206
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TBL1XR1 mRNA20971185
D003300CopperCopper results in increased expression of TBL1XR1 mRNA16629173
D019327Copper SulfateCopper Sulfate results in decreased expression of TBL1XR1 mRNA19549813
D003907DexamethasoneDexamethasone results in increased expression of TBL1XR1 mRNA22733784
D002945CisplatinCisplatin results in decreased expression of TBL1XR1 mRNA19561079|2739243
C000944dicrotophosdicrotophos results in decreased expression of TBL1XR1 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TBL1XR1 mRNA17602206
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TBL1XR1 mRNA22129741
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TBL1XR1 mRNA"22485181
D004317DoxorubicinDoxorubicin results in increased expression of TBL1XR1 mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TBL1XR1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TBL1XR1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of TBL1XR1 mRNA21126777
D005485FlutamideFlutamide results in decreased expression of TBL1XR1 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of TBL1XR1 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of TBL1XR1 mRNA24136188
D006046GoldGold results in decreased expression of TBL1XR1 mRNA25523186
D017313FenretinideFenretinide results in decreased expression of TBL1XR1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TBL1XR1 mRNA20044591|2341063
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TBL1XR1 mRNA22129741
D007545IsoproterenolIsoproterenol results in increased expression of TBL1XR1 mRNA20003209
C544151jinfukangjinfukang results in decreased expression of TBL1XR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of TBL1XR1 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TBL1XR1 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TBL1XR1 mRNA23430699|2479639
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TBL1XR1 mRNA]26733615
C008261lead acetatelead acetate results in decreased expression of TBL1XR1 mRNA25270620
C045463leflunomideleflunomide results in increased expression of TBL1XR1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of TBL1XR1 mRNA24136188
D008558MelphalanMelphalan results in decreased expression of TBL1XR1 mRNA22363485
D008727MethotrexateMethotrexate results in decreased expression of TBL1XR1 mRNA24449571
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to TBL1XR1 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TBL1XR1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TBL1XR1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TBL1XR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TBL1XR1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TBL1XR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TBL1XR1 mRNA"25620056
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TBL1XR1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TBL1XR1 mRNA25729387
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TBL1XR1 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of TBL1XR1 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TBL1XR1 mRNA]26733615
C016030pantogabpantogab results in increased expression of TBL1XR1 mRNA17379144
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TBL1XR1 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of TBL1XR1 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of TBL1XR1 mRNA18301758|1844570
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of TBL1XR1 mRNA]21318169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TBL1XR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TBL1XR1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TBL1XR1 mRNA28903501
C059514resveratrolresveratrol results in decreased expression of TBL1XR1 mRNA25905778
D015474IsotretinoinIsotretinoin results in increased expression of TBL1XR1 mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of TBL1XR1 mRNA21427059
D012834SilverSilver results in decreased expression of TBL1XR1 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of TBL1XR1 mRNA25270620
D018038Sodium SeleniteSodium Selenite results in decreased expression of TBL1XR1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to TBL1XR1 gene]19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TBL1XR1 mRNA19574409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBL1XR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBL1XR1 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBL1XR1 mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TBL1XR1 mRNA28973375
D013849ThimerosalThimerosal results in increased expression of TBL1XR1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of TBL1XR1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TBL1XR1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TBL1XR1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of TBL1XR1 mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TBL1XR1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TBL1XR1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of TBL1XR1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TBL1XR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TBL1XR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TBL1XR1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of TBL1XR1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of TBL1XR1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TBL1XR1 gene25560391
C025643vinclozolinvinclozolin affects the expression of TBL1XR1 mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of TBL1XR1 mRNA23410634
C088658zoledronic acidzoledronic acid results in increased expression of TBL1XR1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA12628926  
GO:0003714transcription corepressor activity-IGI15601853  
GO:0005515protein binding-IPI12628926  25416956  28348241  
GO:0008013beta-catenin binding-IPI18193033  
GO:0042393histone binding-IDA15601853  
GO:0044212transcription regulatory region DNA binding-IDA18193033  
GO:0044212transcription regulatory region DNA binding-ISS-  
GO:0047485protein N-terminus binding-IPI16893456  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12628926  
GO:0002021response to dietary excess-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0016042lipid catabolic process-IEA-  
GO:0016575histone deacetylation-IBA21873635  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0035264multicellular organism growth-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA18193033  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA18193033  
GO:0050872white fat cell differentiation-IEA-  
GO:0060613fat pad development-IEA-  
GO:0090207regulation of triglyceride metabolic process-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IMP18193033  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IBA21873635  
GO:0000118histone deacetylase complexcolocalizes_withIDA18326024  
GO:0005634nucleus-IDA18193033  
GO:0005654nucleoplasm-TAS-  
GO:0005876spindle microtubule-IDA18326024  
GO:0017053transcriptional repressor complex-IDA12628926  15601853  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-1989781PPARA activates gene expressionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)IEA
R-HSA-400253Circadian ClockTAS
R-HSA-400253Circadian ClockIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal