Gene: ASB13

79754
-
ankyrin repeat and SOCS box containing 13
protein-coding
10p15.1
Ensembl:ENSG00000196372 MIM:615055 Vega:OTTHUMG00000017603 UniprotKB:Q8WXK3
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.045e-1 (AD)  3.899e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11256831chr10:5647095 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15835494chr10:5683916ASB13Gene body3.628e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPS7A0.927
NDRG30.926
ACTR1B0.922
DCTN20.921
DALRD30.921
ANXA60.92
GALNT110.917
C12orf430.916
DDX10.916
FARSA0.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.546
MTRNR2L6-0.465
MTRNR2L9-0.454
PPBP-0.436
TGIF1-0.415
MTRNR2L10-0.414
CNN2-0.407
EVC2-0.405
CLEC2B-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ASB13 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of ASB13 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ASB13 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASB13 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASB13 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ASB13 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASB13 mRNA19770486
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of ASB13 mRNA20404318
D001663BilirubinBilirubin results in decreased expression of ASB13 mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of ASB13 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ASB13 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ASB13 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of ASB13 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ASB13 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASB13 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ASB13 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of ASB13 mRNA23811191
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ASB13 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of ASB13 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of ASB13 mRNA19770486
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ASB13 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ASB13 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASB13 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ASB13 mRNA20655997
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ASB13 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ASB13 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ASB13 mRNA23430699
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASB13 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ASB13 mRNA23649840
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ASB13 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of ASB13 mRNA18417182
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ASB13 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ASB13 mRNA19429403
D010634PhenobarbitalPhenobarbital affects the expression of ASB13 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of ASB13 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of ASB13 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of ASB13 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ASB13 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of ASB13 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA19059307
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ASB13 mRNA19073995
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of ASB13 mRNA20937368
D013739TestosteroneTestosterone results in increased expression of ASB13 mRNA21669218
C004648testosterone enanthatetestosterone enanthate affects the expression of ASB13 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ASB13 mRNA19465110
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ASB13 mRNA"26179874
C025643vinclozolinvinclozolin results in decreased expression of ASB13 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16169070  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal